公开(公告)号：EP2334637B1

公开(公告)日：2017-01-04

申请号：EP09785010.1

申请日：2009-08-27

申请人： Japan Tobacco Inc.

发明人： JOHN, Derek, Edward ,  MULLA, Mushtaq ,  HAMLYN, Richard, John ,  JONES, Simon, Mark ,  HARTZOULAKIS, Basil ,  MADGE, David ,  FORD, John

IPC分类号： C07C311/21 ,  C07D213/71 ,  C07D231/18 ,  C07D233/84 ,  C07D233/90 ,  C07D403/12 ,  C07D413/12 ,  C07D295/135 ,  C07D207/27 ,  A61K31/18 ,  A61P29/00

CPC分类号： C07C311/21 ,  C07D207/27 ,  C07D213/71 ,  C07D231/18 ,  C07D233/84 ,  C07D233/90 ,  C07D295/135 ,  C07D403/12 ,  C07D413/12

公开(公告)号：EP2344456B1

公开(公告)日：2018-07-25

申请号：EP09785009.3

申请日：2009-08-27

申请人： Japan Tobacco Inc.

发明人： JOHN, Derek, Edward ,  MULLA, Mushtaq ,  HAMLYN, Richard, John ,  JONES, Simon, Mark ,  POLLARD, Derek, Roland ,  HARTZOULAKIS, Basil ,  PAYNE, Helen ,  MADGE, David ,  FORD, John

IPC分类号： C07D211/08 ,  C07D217/16 ,  C07D231/18 ,  C07D233/84 ,  C07D265/30 ,  C07D277/36 ,  C07D307/64 ,  C07D311/58 ,  C07D333/34 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D295/192 ,  A61K31/18 ,  A61P29/00

CPC分类号： C07D295/18 ,  C07D207/12 ,  C07D211/10 ,  C07D211/16 ,  C07D211/22 ,  C07D211/48 ,  C07D211/52 ,  C07D217/20 ,  C07D231/18 ,  C07D233/84 ,  C07D241/04 ,  C07D265/30 ,  C07D277/36 ,  C07D307/64 ,  C07D311/58 ,  C07D333/34

摘要： The present invention provides a compound of formula (I) or its salts or pharmaceutically acceptable derivatives wherein R1, R2, R3, X1, and A are defined herein. The compounds are useful as potassium ion channel inhibitors.

公开(公告)号：EP2438044B1

公开(公告)日：2019-01-23

申请号：EP10722754.8

申请日：2010-06-04

申请人： Japan Tobacco Inc.

发明人： HAMLYN, Richard, John ,  MADGE, David ,  MULLA, Mushtaq ,  JONES, Simon, Mark ,  HARTZOULAKIS, Basil ,  JOHN, Derek, Edward

IPC分类号： C07D209/46 ,  C07D217/24 ,  C07D401/12 ,  C07D403/12

公开(公告)号：EP2438055B1

公开(公告)日：2018-10-24

申请号：EP10725248.8

申请日：2010-06-04

申请人： Japan Tobacco Inc.

发明人： MADGE, David ,  MULLA, Mushtaq ,  JONES, Simon, Mark ,  HARTZOULAKIS, Basil ,  JOHN, Derek, Edward ,  HAMLYN, Richard, John

IPC分类号： C07D401/12 ,  C07D403/12 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/47 ,  A61P9/00 ,  A61P17/00

CPC分类号： C07D401/12 ,  C07D403/12

摘要： A compound of formula (I): Or its salts or pharmaceutically acceptable derivatives thereof wherein: A represents a chemical moiety with the general formula (II): X and Y are independently selected from a group consisting of CH2, CH(R5) or C(R5)(R6); R1 is selected from the group consisting of optionally substituted arylalkyl, and optionally substituted heteroarylalkyl; R2 is selected from the group consisting of optionally substituted aryl or optionally substituted heteroaryl or NR7R8; R3 R4 R5 R6 R7 and R8 are as defined herein, n=0, 1, 2 or 3; o=0, 1 or 2, with the proviso that when o=0, then n is 1, 2 or 3 and when o=1, then n is 1 or 2 is provided. Pharmaceutical compositions comprising the compounds are also provided. These compounds are useful in the treatment of various disorders including arrhythmia.