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公开(公告)号：EP2334637B1
公开(公告)日：2017-01-04
申请号：EP09785010.1
申请日：2009-08-27
申请人： Japan Tobacco Inc.
发明人： JOHN, Derek, Edward , MULLA, Mushtaq , HAMLYN, Richard, John , JONES, Simon, Mark , HARTZOULAKIS, Basil , MADGE, David , FORD, John
IPC分类号： C07C311/21 , C07D213/71 , C07D231/18 , C07D233/84 , C07D233/90 , C07D403/12 , C07D413/12 , C07D295/135 , C07D207/27 , A61K31/18 , A61P29/00
CPC分类号： C07C311/21 , C07D207/27 , C07D213/71 , C07D231/18 , C07D233/84 , C07D233/90 , C07D295/135 , C07D403/12 , C07D413/12
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2.发明授权
公开(公告)号：EP2438055B1
公开(公告)日：2018-10-24
申请号：EP10725248.8
申请日：2010-06-04
申请人： Japan Tobacco Inc.
发明人： MADGE, David , MULLA, Mushtaq , JONES, Simon, Mark , HARTZOULAKIS, Basil , JOHN, Derek, Edward , HAMLYN, Richard, John
IPC分类号： C07D401/12 , C07D403/12 , A61K31/4155 , A61K31/4178 , A61K31/47 , A61P9/00 , A61P17/00
CPC分类号： C07D401/12 , C07D403/12
摘要： A compound of formula (I): Or its salts or pharmaceutically acceptable derivatives thereof wherein: A represents a chemical moiety with the general formula (II): X and Y are independently selected from a group consisting of CH2, CH(R5) or C(R5)(R6); R1 is selected from the group consisting of optionally substituted arylalkyl, and optionally substituted heteroarylalkyl; R2 is selected from the group consisting of optionally substituted aryl or optionally substituted heteroaryl or NR7R8; R3 R4 R5 R6 R7 and R8 are as defined herein, n=0, 1, 2 or 3; o=0, 1 or 2, with the proviso that when o=0, then n is 1, 2 or 3 and when o=1, then n is 1 or 2 is provided. Pharmaceutical compositions comprising the compounds are also provided. These compounds are useful in the treatment of various disorders including arrhythmia.
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公开(公告)号：EP2344456B1
公开(公告)日：2018-07-25
申请号：EP09785009.3
申请日：2009-08-27
申请人： Japan Tobacco Inc.
发明人： JOHN, Derek, Edward , MULLA, Mushtaq , HAMLYN, Richard, John , JONES, Simon, Mark , POLLARD, Derek, Roland , HARTZOULAKIS, Basil , PAYNE, Helen , MADGE, David , FORD, John
IPC分类号： C07D211/08 , C07D217/16 , C07D231/18 , C07D233/84 , C07D265/30 , C07D277/36 , C07D307/64 , C07D311/58 , C07D333/34 , C07D401/12 , C07D403/12 , C07D413/12 , C07D295/192 , A61K31/18 , A61P29/00
CPC分类号： C07D295/18 , C07D207/12 , C07D211/10 , C07D211/16 , C07D211/22 , C07D211/48 , C07D211/52 , C07D217/20 , C07D231/18 , C07D233/84 , C07D241/04 , C07D265/30 , C07D277/36 , C07D307/64 , C07D311/58 , C07D333/34
摘要： The present invention provides a compound of formula (I) or its salts or pharmaceutically acceptable derivatives wherein R1, R2, R3, X1, and A are defined herein. The compounds are useful as potassium ion channel inhibitors.
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公开(公告)号：EP2438044B1
公开(公告)日：2019-01-23
申请号：EP10722754.8
申请日：2010-06-04
申请人： Japan Tobacco Inc.
发明人： HAMLYN, Richard, John , MADGE, David , MULLA, Mushtaq , JONES, Simon, Mark , HARTZOULAKIS, Basil , JOHN, Derek, Edward
IPC分类号： C07D209/46 , C07D217/24 , C07D401/12 , C07D403/12
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公开(公告)号：EP2342177B1
公开(公告)日：2017-02-15
申请号：EP09785012.7
申请日：2009-08-27
申请人： Japan Tobacco Inc.
发明人： JOHN, Derek, Edward , MULLA, Mushtaq , HAMLYN, Richard, John , GARRETT, Sasha, Louise , HARTZOULAKIS, Basil , MADGE, David , FORD, John
IPC分类号： C07C311/21 , C07D207/12 , C07D209/08 , C07D211/08 , C07D213/04 , C07D231/00 , C07D233/54 , C07D265/30 , C07D265/36 , C07D271/08 , C07D277/32 , C07D285/135 , C07D307/79 , C07D311/70 , C07D317/62 , C07D319/18 , C07D401/12 , C07D413/12 , A61K31/18 , A61P29/00
CPC分类号： C07C311/21 , C07C311/46 , C07C317/32 , C07C317/40 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D207/12 , C07D209/08 , C07D211/16 , C07D211/34 , C07D211/44 , C07D213/36 , C07D213/40 , C07D213/71 , C07D231/12 , C07D231/18 , C07D231/56 , C07D233/61 , C07D233/64 , C07D233/84 , C07D265/30 , C07D265/36 , C07D271/08 , C07D277/28 , C07D277/36 , C07D277/46 , C07D285/12 , C07D285/135 , C07D307/79 , C07D311/70 , C07D317/62 , C07D319/18 , C07D401/12 , C07D403/12 , C07D413/12
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