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    IMPROVED HUMANIZED ANTI-HUMAN 9-INTEGRIN ANTIBODY
    1.
    发明公开
    IMPROVED HUMANIZED ANTI-HUMAN 9-INTEGRIN ANTIBODY 有权
    VERBESSERTER人类抗原抗体-MA9-INTEGRIN-ANTIKÖRPER

    公开(公告)号：EP2243829A1

    公开(公告)日：2010-10-27

    申请号：EP09700904.7

    申请日：2009-01-09

    申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute ,  Astellas Pharma Inc.

    发明人： UEHARA, Kenji ,  HIGUCHI, Hirofumi ,  NAKASHIMA, Toshihiro ,  ISHIKAWA, Daisuke ,  YAMAMOTO, Nobuchika ,  FUJITA, Hirotada ,  SAKAI, Fumihiko

    IPC分类号： C12N15/00 ,  A61K39/395 ,  A61P29/00 ,  C07K16/28 ,  C07K16/46 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/08

    CPC分类号： C07K16/2839 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

    摘要： The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to a donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:11 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:13 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:15 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:9, and a means for the prophylaxis or treatment of various diseases involving human α9 integrin in the pathogenesis, which uses the antibody.

    摘要翻译： 本发明提供与供体小鼠抗人±9整联蛋白抗体相比具有改善的活性和/或性质的人源化抗人±9整联蛋白抗体，即含有重链的人源化抗人±9整联蛋白抗体 由SEQ ID NO：11所示的氨基酸序列组成的可变区和由SEQ ID NO：17所示的氨基酸序列组成的轻链可变区，包含重链的人源化抗人±9整联蛋白抗体 由SEQ ID NO：13所示的氨基酸序列组成的可变区和由SEQ ID NO：17所示的氨基酸序列组成的轻链可变区，包含重链的人源化抗人±9整联蛋白抗体 由SEQ ID NO：15所示的氨基酸序列组成的可变区和由SEQ ID NO：9所示的氨基酸序列组成的轻链可变区，以及预防或治疗涉及人类± 9整数 rin在发病机制中，其使用抗体。

    ANTI-HIV MONOCLONAL ANTIBODY
    4.
    发明授权
    ANTI-HIV MONOCLONAL ANTIBODY 失效
    单克隆抗HIV抗体

    公开(公告)号：EP0690132B1

    公开(公告)日：2003-12-17

    申请号：EP94909286.0

    申请日：1994-03-09

    申请人： JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE

    发明人： EDA, Yasuyuki ,  MAEDA, Hiroaki ,  MAKIZUMI, Keiichi ,  SHIOSAKI, Kouichi ,  OSATOMI, Kiyoshi ,  KIMACHI, Kazuhiko ,  HIGUCHI, Hirofumi ,  TOKIYOSHI, Sachio

    IPC分类号： C12P21/08 ,  C07K14/16

    CPC分类号： C07K16/1063 ,  A61K38/00 ,  C07K2317/24

    摘要： The invention provides a clinically useful monoclonal antibody which can recognize the conserved region of the V3-PND region of a glycoprotein antigen (gp120) having a molecular weight of about 120,000 Da and contained in the coat of a human immunodefiency virus (HIV) and which can neutralize a wide variety of HIV variants, or a fragment of the above antibody, and chimera and humanized antibodies derived from the above antibody. It is possible to prepare a monoclonal antibody having the activity of neutralizing various HIV variants by using as the immunogen several types of peptides having a PND tip region containing a GPGR sequence having a high conservability in the PND region of the gp120 of an HIV. It is possible to obtain a chimera antibody or an altered antibody having an anti-HIV neutralization activity effective for clinical application by transplanting a fragment of a gene coding for the variable region of the above monoclonal antibody or the complementarity-determining region of that region to a human antibody gene.

    METHOD FOR ENHANCING EFFICACY OF PREPARATION OF MONOCLONAL ANTIBODY
    5.
    发明公开
    METHOD FOR ENHANCING EFFICACY OF PREPARATION OF MONOCLONAL ANTIBODY 有权
    方法的提高单克隆抗体的制备的效率

    公开(公告)号：EP1595959A1

    公开(公告)日：2005-11-16

    申请号：EP04712210.6

    申请日：2004-02-18

    申请人： Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute

    发明人： MURAKAMI, Toshio ,  HIGUCHI, Hirofumi ,  MAKIZUMI, Keiichi ,  MAEDA, Toshihiro ,  MIZOKAMI, Hiroshi

    IPC分类号： C12Q1/68 ,  A61K39/395 ,  A61P31/18

    CPC分类号： C07K16/00 ,  A61K2039/505 ,  C07K16/1063 ,  C07K2317/34

    摘要： A method for enhancing efficacy of a monoclonal antibody preparation is provided wherein antigens from patients are tested for their reactivity with said antibody. In accordance with the method of the invention, an amino acid sequence of an expressed protein is deduced from a nucleotide sequence determined by isolation and analysis of a target molecule gene in biopsy from patients and is compared with the previously determined amino acid sequence recognized by said monoclonal antibody preparation to thereby assess fitness of patients for administration of said monoclonal antibody preparation.

    摘要翻译： 提供worin抗原一种用于增强单克隆抗体制备物的功效的方法，从患者测试它们与所述抗体的反应性。 在符合本发明的方法中雅舞蹈，于氨基酸的过量表达的蛋白质的氨基酸序列是从患者通过在活检靶分子基因的分离和分析开采的核苷酸序列确定的推断，并且与由所述识别的以前确定的开采氨基酸序列相比 单克隆抗体的制备，从而评估患者对所述单克隆抗体制剂的给药健身。

    ANTI-HIV MONOCLONAL ANTIBODY
    9.
    发明公开
    ANTI-HIV MONOCLONAL ANTIBODY 失效
    MONOKLONALER抗HIV抗体

    公开(公告)号：EP0690132A1

    公开(公告)日：1996-01-03

    申请号：EP94909286.0

    申请日：1994-03-09

    申请人： JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE

    发明人： EDA, Yasuyuki ,  MAEDA, Hiroaki ,  MAKIZUMI, Keiichi ,  SHIOSAKI, Kouichi ,  OSATOMI, Kiyoshi ,  KIMACHI, Kazuhiko ,  HIGUCHI, Hirofumi ,  TOKIYOSHI, Sachio

    IPC分类号： C12P21/08 ,  C07K15/28

    CPC分类号： C07K16/1063 ,  A61K38/00 ,  C07K2317/24

    摘要： The invention provides a clinically useful monoclonal antibody which can recognize the conserved region of the V3-PND region of a glycoprotein antigen (gp120) having a molecular weight of about 120,000 Da and contained in the coat of a human immunodefiency virus (HIV) and which can neutralize a wide variety of HIV variants, or a fragment of the above antibody, and chimera and humanized antibodies derived from the above antibody. It is possible to prepare a monoclonal antibody having the activity of neutralizing various HIV variants by using as the immunogen several types of peptides having a PND tip region containing a GPGR sequence having a high conservability in the PND region of the gp120 of an HIV. It is possible to obtain a chimera antibody or an altered antibody having an anti-HIV neutralization activity effective for clinical application by transplanting a fragment of a gene coding for the variable region of the above monoclonal antibody or the complementarity-determining region of that region to a human antibody gene.

    摘要翻译： 本发明提供临床有用的单克隆抗体，其可以识别分子量为约120,000Da且包含在人免疫缺陷病毒（HIV）的外壳中的糖蛋白抗原（gp120）的V3-PND区域的保守区域，并且其中 可以中和各种HIV变体，或上述抗体的片段，以及衍生自上述抗体的嵌合体和人源化抗体。 可以制备具有中和各种HIV变异体的活性的单克隆抗体，该单克隆抗体具有在HIV的gp120的PND区域中具有包含具有高保守性的GPGR序列的PND末端区域的几种类型的肽作为免疫原。 可以通过将编码上述单克隆抗体的可变区的基因的片段或该区域的互补决定区域移植到具有对临床应用有效的抗HIV中和活性的嵌合体抗体或改变的抗体 人抗体基因。