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公开(公告)号：EP4003304A1
公开(公告)日：2022-06-01
申请号：EP20753430.6
申请日：2020-07-22
IPC分类号： A61K9/127 , A61K47/16 , A61K47/20 , A61K47/22 , C07C219/06 , C07C219/10 , C07C235/10 , C07C327/30 , C07C327/36 , C07C403/20 , C07C403/22 , C12N15/88 , C12N9/12 , C12N15/85 , C12N15/90 , C12P21/02 , A61K39/00 , C07K14/725
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2.发明公开
公开(公告)号：EP4120999A1
公开(公告)日：2023-01-25
申请号：EP20775943.2
申请日：2020-09-07
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公开(公告)号：EP4028754A1
公开(公告)日：2022-07-20
申请号：EP20717262.8
申请日：2020-02-28
发明人： KOBAYASHI, Nao , ISHIHARA, Mitsuko
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公开(公告)号：EP4331681A3
公开(公告)日：2024-05-22
申请号：EP24150035.4
申请日：2019-03-14
IPC分类号： A61P43/00
CPC分类号： A61K31/7088 , A61K31/7105 , A61K31/711 , A61K45/00 , A61K47/24 , A61K47/18 , A61K47/22 , A61K48/00 , A61P43/00 , C07C229/24 , C07D233/02 , C07D243/08 , C07D251/04 , C07D295/15 , C07D295/13 , C07D211/14 , C07D241/04 , A61K9/1272
摘要： The present embodiment provides a method for delivering activators to cells, wherein said activator containing lipid particles are brought into contact with the cells,
where a compound represented by the formula (1):
Q-CHR2 (1)
wherein
Q is represented by the following formula (1-Q):
RQ12N-(CRQ22)q1-NRQ1-(CRQ22)q2-* (1-Q)
wherein
each RQ1 is independently an alkyl,
each RQ2 is independently hydrogen or an alkyl,
any two of RQ1s and RQ2s may link together to form a nitrogen-containing alicyclic ring,
q1 is an integer of 1 to 4,
q2 is an integer of 0 to 4, and
the mark * indicates the position bonding to -CHR2; and
each R is independently an aliphatic group of C12 to C24;
wherein said R is represented by the following formula (1-R):
-LR1-C(=O)-O-LR2 (1-R)
where
LR1 is alkylene and
LR2 is represented by the following formula (1-R2):
-CH2-CH=CH-(CH2)r2-H (1-R2)
where r2 is an integer of 1 to 10.-
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公开(公告)号：EP4431619A3
公开(公告)日：2024-10-02
申请号：EP23213429.6
申请日：2023-11-30
发明人： ANDO, Tomomi , ISHIHARA, Mitsuko , SANO, Yoshitake
IPC分类号： C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/17820130101 , C12Q2600/15620130101
摘要： According to one arrangement, method of identifying feature of test body is provided. The method includes, measuring a mutation-specific concentration of at least one miRNA contained in the test body, correcting a value of the mutation-specific concentration, and determining whether the test body is a cancer or a non-cancer one using an increase or decrease in the corrected mutation-specific concentration as index.
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公开(公告)号：EP4431619A2
公开(公告)日：2024-09-18
申请号：EP23213429.6
申请日：2023-11-30
发明人： ANDO, Tomomi , ISHIHARA, Mitsuko , SANO, Yoshitake
IPC分类号： C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/17820130101 , C12Q2600/15620130101
摘要： According to one arrangement, method of identifying feature of test body is provided. The method includes, measuring a mutation-specific concentration of at least one miRNA contained in the test body, correcting a value of the mutation-specific concentration, and determining whether the test body is a cancer or a non-cancer one using an increase or decrease in the corrected mutation-specific concentration as index.
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8.发明公开Plasmid vector, method for detecting gene promoter activity, and assay kit 有权Plasmidvektor，Verfahren zum Erkennen derGenpromoteraktivitätund Assaykit
公开(公告)号：EP2562258A1
公开(公告)日：2013-02-27
申请号：EP12181691.2
申请日：2012-08-24
CPC分类号： C12N15/63 , C12N15/69 , C12N15/85 , C12Q1/66 , C12Q1/6897
摘要： According to one embodiment, a plasmid vector (1) includes a gene promoter (10), a first gene (21), a second gene (25), an internal ribosome entry site (23), a transcription termination signal sequence (27) and a replication origin sequence (30). The first gene (21) encodes a reporter protein for visualizing the activity of the gene promoter (10) which is disposed at the downstream of the gene promoter (10). The second gene (25) is disposed at the downstream of the gene promoter (10) and encodes a replication origin-binding protein. The internal ribosome entry site (25) is disposed between the first gene (21) and the second gene (25). The transcription termination signal sequence (27) encodes a signal for terminating the transcription of the first gene (21) and the second gene (25). The replication origin sequence (27) is recognized by the replication origin-binding protein.
摘要翻译： 根据一个实施方案，质粒载体（1）包括基因启动子（10），第一基因（21），第二基因（25），内部核糖体进入位点（23），转录终止信号序列（27） 和复制起始序列（30）。 第一个基因（21）编码报道蛋白，用于显现位于基因启动子（10）下游的基因启动子（10）的活性。 将第二基因（25）置于基因启动子（10）的下游，并编码复制起始结合蛋白。 内部核糖体进入位点（25）位于第一基因（21）和第二基因（25）之间。 转录终止信号序列（27）编码用于终止第一基因（21）和第二基因（25）的转录的信号。 复制起始序列（27）由复制起始结合蛋白识别。
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公开(公告)号：EP4347120A1
公开(公告)日：2024-04-10
申请号：EP22711684.5
申请日：2022-03-04
发明人： AKITA, Masato , FUKUI, Arisa , ISHIHARA, Mitsuko
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10.发明公开
公开(公告)号：EP4326429A1
公开(公告)日：2024-02-28
申请号：EP22711683.7
申请日：2022-03-04
IPC分类号： B01F25/432 , B01F25/433 , B01F33/30
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