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公开(公告)号：EP1123979A4
公开(公告)日：2002-03-27
申请号：EP00954944
申请日：2000-08-24
申请人： KANEKA CORP
发明人： MATSUDA HIDEYUKI , KAWAMUKAI MAKOTO , YAJIMA KAZUYOSHI , IKENAKA YASUHIRO , HASEGAWA JUNZO , TAKAHASHI SATOMI
CPC分类号： C12N9/1085 , C12P7/66
摘要： A process for microbiologically producing coenzyme Q10 at a high efficiency by using a gene of the synthesis of coenzyme Q10 side chain originating in a fungus belonging to the genus Saitoella. A DNA having the base sequence represented by SEQ ID NO:1; a DNA having a base sequence derived from the base sequence represented by SEQ ID NO:1 by deletion, addition, insertion and/or substitution of one or more bases and encoding a protein having a decaprenyl diphosphate synthase activity; and a DNA being hybridizable under stringent conditions with the DNA comprising the base sequence represented by SEQ ID NO:1 and encoding a protein having a decaprenyl diphosphate synthase activity.
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公开(公告)号：EP1876235A4
公开(公告)日：2008-07-09
申请号：EP06730175
申请日：2006-03-28
申请人： KANEKA CORP
发明人： KATO TOMOHISA , IKENAKA YASUHIRO
摘要： A polypeptide having a pantothenate kinase activity, which is derived from a Corynebacterium microorganism capable of producing a pantothenic acid derivative at a high level; DNA encoding the polypeptide; a recombinant vector having the DNA introduced therein; and a transformant having the DNA or the recombinant vector introduced therein. It becomes possible to produce a pantothenic acid derivative including coenzyme A in a large quantity by a biological procedure, and therefore becomes possible to provide a highly safe pantothenic acid derivative with high quality which has been desired in the applications including medicines, functional foods and the like.
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公开(公告)号：EP1336657A4
公开(公告)日：2005-07-27
申请号：EP01982863
申请日：2001-11-20
申请人： KANEKA CORP
CPC分类号： C12N9/1085 , C12P7/66
摘要： A process for efficiently producing coenzyme Q10 by using a microorganism with the use of a coenzyme Q10 side chain synthase gene originating in a fungus belonging to the genus Rodotorula. A DNA having a DNA sequence represented by SEQ ID NO:1, 3 or 5 or a DNA sequence derived therefrom by deletion, addition, insertion and/or substitution of one or several bases and encoding a protein having a decaprenyl diphosphate synthase activity.
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公开(公告)号：EP1209234A4
公开(公告)日：2003-05-02
申请号：EP00956828
申请日：2000-08-30
申请人： KANEKA CORP
发明人： NAKAI TAKAHISA , MORIKAWA SOUICHI , ISHII KIYOTO , NANBA HIROKAZU , YAJIMA KAZUYOSHI , IKENAKA YASUHIRO , TAKAHASHI SATOMI
CPC分类号： C12N9/80
摘要： Excellent decarbamylase variants which are more advantageously usable industrially are provided by clarifying the stereostructure of decarbamylase by X-ray crystalline structure analysis and designing molecules aiming at elevating the reactivity to the substrates (D-N-carbamoyl- alpha -amino acids), etc. by using the stereostructure. More particularly speaking, provision is made of: the stereostructure of decarbamylase determined by X-ray crystalline structure analysis, stereostructure models of variants thereof and stereostructure models of complexes thereof with substrates, products, etc.; a molecular design method with the use of these stereostructures; a method of obtaining decarbamylase variants by using this method; the decarbamylase variants obtained by this method; and a method of designing and producing variants of proteins which are similar to decarbamylase in structure.
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公开(公告)号：EP1354957A4
公开(公告)日：2005-01-26
申请号：EP01271890
申请日：2001-12-27
申请人： KANEKA CORP
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N9/12 , C12N15/54 , C12P7/66 , C12R1/19
CPC分类号： C12N9/1085 , C12P7/66 , C12Y205/01031
摘要： A process for efficiently producing coenzyme Q10 by using microorganisms wherein coenzyme Q10 side-chain synthesis genes originating in fungi belonging to the genera Aspergillus and Leucosporidium are used. DNA having a DNA sequence represented by SEQ ID NO:1 or 2 or a DNA sequence derived therefrom by deletion, addition, insertion or substitution of one or more bases and encoding a protein having a decaprenyl diphosphate synthase activity.
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公开(公告)号：EP1070759A4
公开(公告)日：2003-01-22
申请号：EP00902071
申请日：2000-02-03
申请人： KANEKA CORP
发明人： MATSUDA HIDEYUKI , KAWAMUKAI MAKOTO , KAZUYOSHI YAJIMA , IKENAKA YASUHIRO , NISHI KENICHI , HASEGAWA JUNZO , TAKAHASHI SATOMI
CPC分类号： C12N9/1085 , C12P7/66
摘要： A gene of decaprenyl diphosphate synthase, which is the key gene participating in the biosynthesis of coenzyme Q10 was isolated from a bacterium belonging to the family Rhizobiaceae. By transferring this gene into a microorganism such as Escherichia coli and expressing therein, coenzyme Q10 can be effectively produced.
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公开(公告)号：EP1045025A4
公开(公告)日：2002-10-31
申请号：EP99951134
申请日：1999-10-29
申请人： KANEKA CORP
CPC分类号： C12N9/1096 , C12P41/006
摘要： An enzyme capable of converting a ketone compound into an optically active amino compound via a transamination reaction and a process for producing an optically active amino compound by using this enzyme. (S)- alpha -Phenethylamine:pyruvate transaminase which acts on (S)- alpha -phenethylamine and a ketone compound and catalyzes a transamination reaction whereby acetophenone and an amino compound corresponding to the ketone compound are formed; a process for producing an optically active amino compound by using the transaminase; and a method for culturing a microorganism producing the above transaminase wherein at least one inducer selected from the group consisting of propylamine, 1-butylamine, 2-butylamine, 2-pentylamine, isopropylamine and isobutylamine is added to the medium in culturing the transaminase-producing microorganism.
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公开(公告)号：EP0987332A4
公开(公告)日：2002-03-06
申请号：EP98914111
申请日：1998-04-20
申请人： KANEKA CORP
发明人： YAMADA YUKIO , IWASAKI AKIRA , KIZAKI NORIYUKI , MATSUMOTO KEIJI , IKENAKA YASUHIRO , OGURA MASAHIRO , HASEGAWA JUNZO
CPC分类号： C12P13/001 , C12N9/1096
摘要： A process for efficiently producing optically active amino compounds, mainly (R)-amino compounds, at a low cost by means of a microbial enzyme; a polypeptide suitable for use in the production process and having a stereoselective transaminase activity; and a DNA coding for the polypeptide. The process is characterized by comprising causing a transaminase to act on a ketone compound as an amino acceptor in the presence of a primary amine as an amino donor to stereoselectively transfer the amino group to thus obtain an optically active amino compound. The DNA contains a base sequence coding for a polypeptide having a stereoselective transaminase activity. The polypeptide can be obtained by incubating a microorganism belonging to the genus Arthrobacter.
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公开(公告)号：EP0857790A4
公开(公告)日：1999-08-18
申请号：EP96935392
申请日：1996-10-21
申请人： KANEKA CORP
发明人： YAMADA YUKIO , IWASAKI AKIRA , KIZAKI NORIYUKI , IKENAKA YASUHIRO , OGURA MASAHIRO , HASEGAWA JUNZO
CPC分类号： C12P13/001 , C12N9/1096 , C12P13/005 , C12P13/008 , C12P13/04 , C12P41/006 , Y10S435/83
摘要： A process for producing optically active (R)-amino compounds which comprises treating an aralkyl alkyl ketone compound (the amino receptor) coexisting with a racemic or (R)-amino compound (the amino donor) with an (R)-specific transaminase produced by a microorganism belonging to the genus Arthrobacter and thus effecting stereoselective transamination. This process makes it possible to facilitate the production in a high yield of optically active (R)-amino compounds, etc., having aryl, etc. at the 1-position which have been difficult to synthesize by the conventional techniques.
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