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    BODY FLUID PROCESSOR ENABLING DIRECT HEMOPERFUSION
    3.
    发明授权
    BODY FLUID PROCESSOR ENABLING DIRECT HEMOPERFUSION 有权
    体液处理装置中，直接血液灌流允许

    公开(公告)号：EP1356832B1

    公开(公告)日：2012-07-11

    申请号：EP02711232.5

    申请日：2002-01-30

    申请人： KANEKA CORPORATION

    发明人： NAKATANI, Masaru ,  KOBAYASHI, Akira ,  FURUYOSHI, Shigeo

    IPC分类号： A61M1/00

    CPC分类号： A61M1/3679 ,  A61M1/3633 ,  A61M2202/0413 ,  B01J2220/62 ,  A61M2202/0021

    摘要： A safe and practically useful body fluid processor whereby blood taken out from a patient can be directly processed, characterized by having a favorable blood cell permeability and showing an extremely low risk of the generation and leakage of fine particles. Namely, a body fluid processor enabling direct hemoperfusion wherein the ratio of sedimented particles to the volume of the space in which the particles for processing body are to be packed is 100% or less and the space in which the particles for processing body fluid are to be packed in the body fluid processor is filled with the particles for processing body fluid and a filling liquid at a ratio of 95% or more but not more than 100%.

    BODY FLUID PROCESSOR ENABLING DIRECT HEMOPERFUSION
    4.
    发明公开
    BODY FLUID PROCESSOR ENABLING DIRECT HEMOPERFUSION 有权
    KÖRPERFLÜSSIGKEITSVERARBEITUNGSGERÄT，DAS DIREKTEHÄMOPERFUSIONERMÖGLICHT

    公开(公告)号：EP1356832A1

    公开(公告)日：2003-10-29

    申请号：EP02711232.5

    申请日：2002-01-30

    申请人： KANEKA CORPORATION

    发明人： NAKATANI, Masaru ,  KOBAYASHI, Akira ,  FURUYOSHI, Shigeo

    IPC分类号： A61M1/00

    CPC分类号： A61M1/3679 ,  A61M1/3633 ,  A61M2202/0413 ,  B01J2220/62 ,  A61M2202/0021

    摘要： A safe and practically useful body fluid processor whereby blood taken out from a patient can be directly processed, characterized by having a favorable passage of the blood cell and showing an extremely low risk of the generation and leakage of microparticles. Namely, a body fluid processor enabling direct hemoperfusion wherein the ratio of sedimented particles to the volume of the space in which the particles for processing body fluid are to be packed is 100% or less and the space in which the particles for processing body fluid are to be packed in the body fluid processor is filled with the particles for processing body fluid and a filling liquid at a ratio of 95% or more but not more than 100%.

    摘要翻译： 一种安全实用的体液处理器，其中可以直接处理从患者取出的血液，其特征在于具有血液细胞的良好通过并且显示出微粒产生和泄漏的极低风险。 也就是说，能够进行直接血液灌注的体液处理器，其中，沉积粒子与待填充体液的颗粒的空间的体积的比例为100％以下，体液加工用颗粒的空间为 填充在体液处理器中的填充有用于加工体液的颗粒和填充液，比例为95％以上但不超过100％。

    GRANULOCYTE ADSORBENT
    5.
    发明公开
    GRANULOCYTE ADSORBENT 有权
    颗粒状吸附剂

    公开(公告)号：EP1792635A1

    公开(公告)日：2007-06-06

    申请号：EP05781504.5

    申请日：2005-08-30

    申请人： Kaneka Corporation

    发明人： KOBAYASHI, Akira ,  YOSHIDA, Shinya ,  NIWA, Hideo

    IPC分类号： A61M1/36 ,  A61K35/14 ,  B01J20/26 ,  G01N33/48

    CPC分类号： B01J20/26 ,  A61M1/3679 ,  A61M2202/0441 ,  B01J20/261 ,  B01J20/262 ,  B01J20/265

    摘要： This invention relates to a granulocyte adsorbent comprising a polymer compound having an unsubstituted hydroxyl group and a hydroxyl group in which H has been substituted with at least one substituent R, a method for producing such adsorbent, a device for adsorbing granulocytes and a system for removing granulocytes using such adsorbent, and body fluid or a cell suspension from which granulocytes have been removed using such adsorbent.

    摘要翻译： 本发明涉及包含具有未取代的羟基和羟基的聚合物化合物的粒细胞吸附剂，其中H已经被至少一个取代基R取代，该吸附剂的制备方法，用于吸附粒细胞的装置和用于除去 使用这种吸附剂的粒细胞，以及使用这种吸附剂除去粒细胞的体液或细胞悬浮液。

    DIRECT HEMOPERFUSION ADSORBER PACKED WITH ADSORBENT HAVING WATER INSOLUBLE MICROPARTICLE REMOVED THEREFROM, AND METHOD OF OBTAINING DIRECT HEMOPERFUSION ADSORBENT HAVING WATER INSOLUBLE MICROPARTICLE REMOVED THEREFROM
    6.
    发明公开
    DIRECT HEMOPERFUSION ADSORBER PACKED WITH ADSORBENT HAVING WATER INSOLUBLE MICROPARTICLE REMOVED THEREFROM, AND METHOD OF OBTAINING DIRECT HEMOPERFUSION ADSORBENT HAVING WATER INSOLUBLE MICROPARTICLE REMOVED THEREFROM 有权
    DIRECTHÄMOPERFUSIONSADSORBER，吸附剂挤满了文章远水不溶性微粒和方法保持直接HÄMOPERFUSIONSADSORBENS被添加的文章远水不溶性微粒

    公开(公告)号：EP1790365A1

    公开(公告)日：2007-05-30

    申请号：EP05766271.0

    申请日：2005-07-20

    申请人： Kaneka Corporation

    发明人： FUJITA, Koji ,  NAKATANI, Masaru ,  KOBAYASHI, Akira ,  NISHIMOTO, Takehiro

    IPC分类号： A61M1/36 ,  A61L33/00 ,  B01J20/28

    CPC分类号： A61M1/3679 ,  A61M1/3627 ,  B01J20/24 ,  B01J20/28004 ,  B01J20/3212 ,  Y10T428/2982

    摘要： The present invention has its object to provide a direct hemoperfusion adsorber packed with an adsorbent made by using a water-insoluble carrier having a relatively readily available particle size distribution, with water-insoluble microparticles having been removed therefrom, without needing any special granulation apparatus or coating apparatus, and method of obtaining a direct hemoperfusion adsorbent having water-insoluble microparticles removed therefrom.
    Now, a direct hemoperfusion adsorber has been obtained that is packed with an adsorbent having a number average particle diameter of not smaller than 300 µm but not larger than 600 µm, with the coefficient of variance in particle diameter distribution being not lower than 10% but not higher than 20%, and having water-insoluble microparticles removed therefrom to a safe level, without the loss of the adsorbent, by using a water-insoluble microparticle-removing-mesh such that the ratio of the mesh opening size for removing water-insoluble microparticles to the mesh opening size of the adsorber is not lower than 1.3 but not higher than 1.5.

    摘要翻译： 本发明具有的目的是提供在通过使用具有相对容易获得的粒径分布的水不溶性载体制成吸附剂填充有直接血液灌流吸附器，与水不溶性微粒已经从那里取出，而无需任何特殊的造粒装置或 涂敷装置，并获得具有从那里除去水不溶性微粒的直接血液灌流吸附剂的方法。 现在，直接血液灌流吸附器已经获得并填充有但是具有不小于300微米的数均粒径，但不大于600微米的吸附剂，具有方差的粒径分布为不低于10％系数 不高于20％，和具有水不溶性微粒从到安全水平去除在那里，而不吸附剂的损失，通过使用水不溶性微粒除去目检查做的筛孔开口尺寸的用于去除水的比例 不溶性微粒的吸附器的网孔尺寸不低于1.3但不高于1.5。

    BLOOD COMPONENT SEPARATION SYSTEM AND SEPARATION MATERIAL
    8.
    发明公开
    BLOOD COMPONENT SEPARATION SYSTEM AND SEPARATION MATERIAL 审中-公开
    BLUTBESTANDTETRTRANNSYSTEM UND TRENNMATERIAL

    公开(公告)号：EP2450431A1

    公开(公告)日：2012-05-09

    申请号：EP10794105.6

    申请日：2010-06-28

    申请人： Kaneka Corporation

    发明人： SATO, Nobuhiko ,  YOSHIDA, Shinya ,  KOBAYASHI, Akira ,  NAKATANI, Masaru

    IPC分类号： C12N5/078 ,  A61M1/02 ,  A61M1/34 ,  B01D39/16 ,  B03B5/00 ,  C12M1/26 ,  C12N5/0775 ,  C12N5/0789 ,  D04H3/00

    摘要： The present invention relates to a separation system and a separation material for easily and rapidly separating a red blood cell-rich fraction, a white blood cell-rich fraction, and/or a platelet-rich fraction from a biological fluid containing these blood cell components without the necessity of performing centrifugation. The separation of a red blood cell-rich fraction, a white blood cell-rich fraction, and/or a platelet-rich fraction from a biological fluid can be accomplished by capturing white blood cells and platelets on a blood cell separation material by contacting the biological fluid with the blood cell separation material, thereby providing a red blood cell-rich fraction; and recovering a white blood cell-rich fraction by separating white blood cells captured from the resulting blood cell separation material using a separation solution.

    摘要翻译： 本发明涉及一种分离系统和分离材料，用于从含有这些血细胞成分的生物流体中容易且快速地分离富含红细胞的部分，富含白细胞的部分和/或富含血小板的部分 而不需要进行离心。 通过将血细胞分离材料上的白细胞和血小板与血细胞分离物质接触，可以实现从生物流体中分离富含红血细胞的部分，富含白细胞的部分和/或血小板富集部分 生物流体与血细胞分离物质，从而提供富含红细胞的部分; 并通过使用分离溶液分离从所得血细胞分离材料捕获的白细胞来回收富含白细胞的级分。

    STEM CELL SEPARATING MATERIAL AND METHOD OF SEPARATION
    9.
    发明公开
    STEM CELL SEPARATING MATERIAL AND METHOD OF SEPARATION 审中-公开
    STAMMZELLENTRENNMATERIAL UND TRENNVERFAHREN

    公开(公告)号：EP1947170A1

    公开(公告)日：2008-07-23

    申请号：EP06812085.6

    申请日：2006-10-20

    申请人： Kaneka Corporation

    发明人： KOBAYASHI, Akira ,  YAMAMOTO, Kazuaki ,  YOSHIDA, Shinya ,  NIWA, Hideo ,  IMAI, Naohiro ,  KURATA, Hirokazu ,  MIYAMOTO, Yoshiaki

    IPC分类号： C12M1/26 ,  B01D39/04 ,  B01D39/16

    CPC分类号： C12N5/0607 ,  B01D39/1623 ,  B01D39/1692 ,  B01D2239/0414 ,  C12M33/14 ,  C12M47/02

    摘要： The present invention has its object to provide a material for separating stem cell and a filter for separating stem cell, each is capable of selectively separating and recovering, in a simple and easy manner, stem cells from body fluids or biological tissue-derived treated fluids, a method for separating and recovering stem cells, and stem cells obtained by such method. The present invention is a material for separating stem cell which has a density K of 1.0 x 10 4 ≤ K ≤ 1.0 x 10 6 and a fiber diameter of 3 to 40 µm; a filter for separating stem cell which comprises the material for separating stem cell as packed in a container having a fluid inlet port and a fluid outlet port; a method of separating and recovering stem cells which comprises using the material for separating stem cell or the filter for separating stem cell; and a method of producing a multipotent cell fraction.

    摘要翻译： 本发明的目的是提供用于分离干细胞的材料和用于分离干细胞的过滤器，每种能够以简单和容易的方式从体液或生物组织衍生的处理液中分离和回收干细胞 ，分离和回收干细胞的方法和通过这种方法获得的干细胞。 本发明是用于分离密度K为1.0×10 4‰K‰1.0×10 6，纤维直径为3〜40μm的干细胞的材料。 用于分离干细胞的过滤器，其包括用于分离干细胞的材料，所述干细胞包装在具有流体入口和流体出口的容器中; 一种分离和回收干细胞的方法，其包括使用用于分离干细胞的材料或用于分离干细胞的过滤器; 以及多能细胞部分的制造方法。

    HYDROPHILIZED MEMBRANE AND METHOD OF HYDROPHILIZATION THEREFOR
    10.
    发明授权
    HYDROPHILIZED MEMBRANE AND METHOD OF HYDROPHILIZATION THEREFOR 无效
    亲水膜和亲水THEREOF

    公开(公告)号：EP1334763B1

    公开(公告)日：2006-12-20

    申请号：EP01974897.9

    申请日：2001-10-23

    申请人： KANEKA CORPORATION

    发明人： KOBAYASHI, Akira ,  OIDE, Yasuhito ,  FUJITA, Koji ,  TANI, Nobutaka

    IPC分类号： B01D69/00 ,  A61L31/06 ,  A61L31/14

    CPC分类号： B01D67/0088 ,  A61L31/06 ,  A61L31/146 ,  C08L81/06

    摘要： A hydrophilized membrane which is obtained by easily hydrophilizing, e.g., a hydrophobic porous membrane and is greatly inhibited from suffering adhesion of blood cells such as erythrocytes, leukocytes, and blood platelets thereto. The hydrophilized hydrophobic porous membrane is characterized by being obtained by immersing a medical supply having a hydrophobic part to be in contact with blood in a solution of a substance having surface activity and then rinsing the medical supply with a solvent in which the surfactant is soluble to thereby adsorb, in an extremely slight amount, the substance having surface activity onto the surface of the part to be in contact with blood. It is further characterized in that the adhesion of blood cells such as erythrocytes, leukocytes, and blood platelets to the membrane is greatly inhibited.