公开(公告)号：EP2229592A4

公开(公告)日：2013-10-16

申请号：EP08807592

申请日：2008-09-10

申请人： KIMBERLY CLARK CO

发明人： PLOWMAN THOMAS EDWARD ,  RAINONE MIKE ,  BAIRD DANIEL ,  HANTKE RICHARD ,  PHILLIPS ERICA M ,  PRESLEY TALBOT

IPC分类号： G01N33/569 ,  A61B5/00 ,  A61K49/00 ,  C12Q1/04 ,  G01N21/00 ,  G01N21/64 ,  G01N21/77 ,  G01N33/535

CPC分类号： G01N21/7703 ,  A61B5/0071 ,  A61K49/0013 ,  A61K49/0047 ,  A61K49/0097 ,  C12Q1/04 ,  G01N2021/7786 ,  G01N2021/7796

摘要： Disclosed herein are methods and devices for detection of bacterial HAI. Disclosed methods may be utilized for continuous in vivo monitoring of a potential bacterial infection site and may be utilized to alert patients and/or health care providers to the presence of pathogenic bacteria at an early stage of infection. Disclosed methods include utilization of recombinant bacteriophage to deliver to pathogenic bacteria a translatable genetic sequence encoding an optically detectable marker or an enzyme capable of producing an optically detectable marker. Upon detection of the optical signal produced by the marker, medical personnel may be alerted to the presence of pathogenic bacteria at the site of inquiry. Any bacterial causative agent of HAI may be detected according to disclosed methods.

公开(公告)号：EP2217907A4

公开(公告)日：2013-08-07

申请号：EP08807589

申请日：2008-09-10

申请人： KIMBERLY CLARK CO

发明人： RAINONE MIKE ,  PLOWMAN THOMAS EDWARD ,  BAIRD DANIEL ,  HANTKE RICHARD ,  PHILLIPS ERICA M ,  PRESLEY TALBOT

IPC分类号： G01N21/00 ,  C12Q1/37 ,  G01N33/535 ,  G01N33/569

CPC分类号： A61B5/0059 ,  A61B5/445 ,  C12Q1/04 ,  C12Q1/37 ,  C12Q1/66 ,  G01N21/6428 ,  G01N21/648 ,  G01N21/7703 ,  G01N2021/6441 ,  G01N2021/7716 ,  G01N2021/772 ,  G01N2021/773 ,  G01N2201/0221