公开(公告)号：EP0445742B1

公开(公告)日：1997-06-04

申请号：EP91103329.8

申请日：1991-03-05

申请人： KOWA COMPANY, LTD. ,  YUASA CORPORATION

发明人： Inagi, Toshio ,  Muramatsu, Toyojiro ,  Nagai, Hidetaka ,  Murata, Kazuo, c/o Yuasa Battery Co., Ltd. ,  Takeuchi, Kenichi, c/o Yuasa Battery Co., Ltd. ,  Izuchi, Shuichi, c/o Yuasa Battery Co., Ltd.

IPC分类号： A61N1/30

CPC分类号： A61N1/303 ,  A61N1/20

公开(公告)号：EP0752457A2

公开(公告)日：1997-01-08

申请号：EP96110234.0

申请日：1996-06-25

申请人： KOWA COMPANY LTD.

发明人： Inagi, Toshio ,  Kanebako, Makoto

IPC分类号： C09J129/04 ,  C09J133/14 ,  A61M35/00

CPC分类号： A61K9/7061 ,  A61K47/32 ,  A61L15/58 ,  C08L29/04 ,  C08L2666/04 ,  C09J133/14 ,  C08L33/06

摘要： Described is a hydrophilic adhesive base material comprising a hydrophilic crosslinked polymer obtained by polymerizing (A) (a) a glucosyloxyalkyl (meth)acrylate, (b) an alkyl (meth)acrylate and/or a hydroxyalkyl (meth)acrylate and (c) a polyfunctional monomer; and (B) polyvinyl alcohol. The hydrophilic adhesive base material according to the present invention is free from lowering in the water content and has excellent mechanical strength and adhesion to the skin so that it is useful as adhesive layers in plasters, various medical pads and also medicament-impregnated dermatologic medicines.

摘要翻译： 描述了包含通过（A）（a）（甲基）丙烯酸葡糖基氧烷基酯，（b）（甲基）丙烯酸烷基酯和/或（甲基）丙烯酸羟烷基酯）和（c）聚合得到的亲水性交联聚合物的亲水性粘合剂基材， 多官能单体; 和（B）聚乙烯醇。 本发明的亲水性粘合剂基材不含水分降低，并且具有优异的机械强度和对皮肤的粘附性，因此其可用作石膏，各种医用垫中的粘合剂层以及药物浸渍的皮肤病学药物。

公开(公告)号：EP0752457B1

公开(公告)日：2001-09-05

申请号：EP96110234.0

申请日：1996-06-25

申请人： KOWA COMPANY LTD.

发明人： Inagi, Toshio ,  Kanebako, Makoto

IPC分类号： C09J129/04 ,  C09J133/14 ,  A61M35/00

CPC分类号： A61K9/7061 ,  A61K47/32 ,  A61L15/58 ,  C08L29/04 ,  C08L2666/04 ,  C09J133/14 ,  C08L33/06

摘要： Described is a hydrophilic adhesive base material comprising a hydrophilic crosslinked polymer obtained by polymerizing (A) (a) a glucosyloxyalkyl (meth)acrylate, (b) an alkyl (meth)acrylate and/or a hydroxyalkyl (meth)acrylate and (c) a polyfunctional monomer; and (B) polyvinyl alcohol. The hydrophilic adhesive base material according to the present invention is free from lowering in the water content and has excellent mechanical strength and adhesion to the skin so that it is useful as adhesive layers in plasters, various medical pads and also medicament-impregnated dermatologic medicines.

公开(公告)号：EP0093563A2

公开(公告)日：1983-11-09

申请号：EP83302348.4

申请日：1983-04-26

申请人： KOWA COMPANY, LTD.

发明人： Inagi, Toshio ,  Inoue, Masayuki ,  Muramatsu, Toyojiro

IPC分类号： A61K9/08 ,  A61K31/405 ,  A61K47/00

CPC分类号： A61K9/7076 ,  A61K9/0014 ,  A61K31/405 ,  A61K47/08 ,  A61K47/10 ,  Y10S514/97

摘要： A pharmaceutical preparation for endermic application is disclosed which comprises indomethacin and at least one solubilizer selected from C 10 terpenoids and C 10 phenols. The addition of these solubilizers in small quantities significantly increase the solubility and stability of indomethacin in various solvents and thus produce indomethacin solutions which can be used perse, or incorporated in a wide variety of bases to provide endermically-applicable preparations of various forms.

公开(公告)号：EP0689841B1

公开(公告)日：2003-01-02

申请号：EP95108920.0

申请日：1995-06-09

申请人： KOWA COMPANY, LTD.

发明人： Inagi, Toshio ,  Suehiro, Saibi

IPC分类号： A61K33/18 ,  A61K31/70 ,  A61K9/14 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38

CPC分类号： A61K9/0014 ,  A61K9/145 ,  A61K9/146 ,  A61K31/79 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K31/7004 ,  A61K31/78 ,  A61K31/765 ,  A61K31/717 ,  A61K2300/00

公开(公告)号：EP0445742A1

公开(公告)日：1991-09-11

申请号：EP91103329.8

申请日：1991-03-05

申请人： KOWA COMPANY, LTD. ,  YUASA BATTERY CO., LTD.

发明人： Inagi, Toshio ,  Muramatsu, Toyojiro ,  Nagai, Hidetaka ,  Murata, Kazuo, c/o Yuasa Battery Co., Ltd. ,  Takeuchi, Kenichi, c/o Yuasa Battery Co., Ltd. ,  Izuchi, Shuichi, c/o Yuasa Battery Co., Ltd.

IPC分类号： A61N1/30

CPC分类号： A61N1/303 ,  A61N1/20

摘要： An electrotherapeutic device for passing a DC electric current through a living organism by applying a voltage to the living organism is disclosed. A device is provided with a battery with an internal resistance of high impedance of a degree that the changes in the resistance value of the living organism can be disregarded. By doing so, no excessive flow of current is produced even if the resistance of the living organism fluctuates. The device is safe, easy to handle, and inexpensive. It is particularly suited for use with iontophoresis; a technology by which drugs are administered by means of the passage of electricity.

摘要翻译： 公开了一种通过向生物体施加电压使直流电流通过活体的电疗装置。 设备具有电阻器，该电池具有可以忽略生物体的电阻值的变化程度的高阻抗的内阻。 通过这样做，即使生物体的抗性波动也不会产生过大的电流。 该设备安全，易于处理，价格便宜。 特别适用于离子电渗疗法; 药物通过电力进行管理的技术。

公开(公告)号：EP0055029A3

公开(公告)日：1982-09-15

申请号：EP81305526

申请日：1981-11-24

申请人： KOWA COMPANY, LTD.

发明人： Nagai, Hidetaka ,  Muramatsu, Toyojiro ,  Inagi, Toshio

IPC分类号： A61K09/06 ,  A61K07/48 ,  A61K31/405

CPC分类号： A61K9/0014 ,  A61K8/492 ,  A61K31/405 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/44 ,  A61Q19/00 ,  A61Q19/004

摘要： An external preparation for the treatment of dermatoses is in the form of an ungelled ointment or cream comprising indomethacin as an active component and preferably also containing an adjuvant for increasing the release of indomethacin from the preparation. Such preparations exhibit a superior remedial effect when applied directly to any affected parts of the skin.

公开(公告)号：EP0752457A3

公开(公告)日：1999-07-28

申请号：EP96110234.0

申请日：1996-06-25

申请人： KOWA COMPANY LTD.

发明人： Inagi, Toshio ,  Kanebako, Makoto

IPC分类号： C09J129/04 ,  C09J133/14 ,  A61M35/00

CPC分类号： A61K9/7061 ,  A61K47/32 ,  A61L15/58 ,  C08L29/04 ,  C08L2666/04 ,  C09J133/14 ,  C08L33/06

摘要： Described is a hydrophilic adhesive base material comprising a hydrophilic crosslinked polymer obtained by polymerizing (A) (a) a glucosyloxyalkyl (meth)acrylate, (b) an alkyl (meth)acrylate and/or a hydroxyalkyl (meth)acrylate and (c) a polyfunctional monomer; and (B) polyvinyl alcohol. The hydrophilic adhesive base material according to the present invention is free from lowering in the water content and has excellent mechanical strength and adhesion to the skin so that it is useful as adhesive layers in plasters, various medical pads and also medicament-impregnated dermatologic medicines.

公开(公告)号：EP0055029B1

公开(公告)日：1985-11-21

申请号：EP81305526.6

申请日：1981-11-24

申请人： KOWA COMPANY, LTD.

发明人： Nagai, Hidetaka ,  Muramatsu, Toyojiro ,  Inagi, Toshio

IPC分类号： A61K9/06 ,  A61K7/48 ,  A61K31/405

CPC分类号： A61K9/0014 ,  A61K8/492 ,  A61K31/405 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/44 ,  A61Q19/00 ,  A61Q19/004

公开(公告)号：EP0093563A3

公开(公告)日：1984-09-12

申请号：EP83302348

申请日：1983-04-26

申请人： KOWA COMPANY, LTD.

发明人： Inagi, Toshio ,  Inoue, Masayuki ,  Muramatsu, Toyojiro

IPC分类号： A61K09/08 ,  A61K31/405 ,  A61K47/00

CPC分类号： A61K9/7076 ,  A61K9/0014 ,  A61K31/405 ,  A61K47/08 ,  A61K47/10 ,  Y10S514/97

摘要： A pharmaceutical preparation for endermic application is disclosed which comprises indomethacin and at least one solubilizer selected from C 10 terpenoids and C 10 phenols. The addition of these solubilizers in small quantities significantly increase the solubility and stability of indomethacin in various solvents and thus produce indomethacin solutions which can be used perse, or incorporated in a wide variety of bases to provide endermically-applicable preparations of various forms.