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1.发明授权Physiologically active substance K-252, process for producing same and a pharmaceutical composition containing same 失效生理活性物质K-252，其生产方法和含有该物质的药物组合物
公开(公告)号：EP0137632B1
公开(公告)日：1990-10-31
申请号：EP84305465.1
申请日：1984-08-10
发明人： Matsuda, Yuzuru , Iwahashi, Kazuyuki , Iida, Takao , Hirayama, Noriaki , Asano, Kozo , Shuto, Katsuichi , Yamada, Koji , Shirahata, Kunikatsu , Kase, Hiroshi
摘要： A novel physiologically active substance K-252 having an antiallergic action is produced by culturing a microorganism of the genus Nocardiopsis.
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公开(公告)号：EP0300294B1
公开(公告)日：1993-11-03
申请号：EP88110939.1
申请日：1988-07-08
发明人： Nakano, Hirofumi , Hara, Mitsunobu , Takahashi, Isami , Asano, Kozo , Iida, Takao , Morimoto, Makoto
CPC分类号： C12P1/06 , C12R1/465 , Y10S435/886
摘要： A novel compound, DC-107, with the following physicochemical properties: (1) Molecular formula: C22H26N2O6S3 (2) Molecular weight: 510 Found by high resolution FAB mass spectrum : 511.1041 Calculated for C22H27N2O6S3 : 511.1031 (3) Melting point: 160 DEG C (decomposed) (4) Specific rotation: [ alpha ]25_D = 140 DEG (c=0.1, methanol) obtained by culturing a microorganism belonging to the genus Streptomyces. It is useful as a medicine because of its antibacterial and anti-tumor activity.
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3.发明公开Physiologically active substance K-252, process for producing same and a pharmaceutical composition containing same 失效生理活性物质K-252，其制备方法和含有它们的药物组合物的方法。
公开(公告)号：EP0137632A2
公开(公告)日：1985-04-17
申请号：EP84305465.1
申请日：1984-08-10
发明人： Matsuda, Yuzuru , Iwahashi, Kazuyuki , Iida, Takao , Hirayama, Noriaki , Asano, Kozo , Shuto, Katsuichi , Yamada, Koji , Shirahata, Kunikatsu , Kase, Hiroshi
摘要： A novel physiologically active substance K-252 having an antiallergic action is produced by culturing a microorganism of the genus Nocardiopsis.
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公开(公告)号：EP0264138B1
公开(公告)日：1991-12-04
申请号：EP87115147.8
申请日：1987-10-16
CPC分类号： C12R1/465 , C07D243/14 , C12P17/165
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公开(公告)号：EP0300294A3
公开(公告)日：1990-03-21
申请号：EP88110939.1
申请日：1988-07-08
发明人： Nakano, Hirofumi , Hara, Mitsunobu , Takahashi, Isami , Asano, Kozo , Iida, Takao , Morimoto, Makoto
CPC分类号： C12P1/06 , C12R1/465 , Y10S435/886
摘要： A novel compound, DC-107, is produced by culturing a microorganism belonging to the genus Streptomyces. It is useful as a medicine because of its antibacterial and anti-tumor activity.
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6.发明公开Novel compound DC-102 and process for production thereof 失效Verbindung DC-102和Verfahren zu ihrer Herstellung。
公开(公告)号：EP0264138A2
公开(公告)日：1988-04-20
申请号：EP87115147.8
申请日：1987-10-16
CPC分类号： C12R1/465 , C07D243/14 , C12P17/165
摘要： A novel compound, DC-102, having benzodiazepin nucleus is produced by culturing a microorganism belonging to the genus Streptomyces . It is useful as a medicine because of its antibacterial and anti-tumor activities.
摘要翻译： 通过培养属于链霉菌属的微生物产生具有苯并二氮杂环核心的新化合物DC-102。 由于其抗菌和抗肿瘤活性，它作为药物是有用的。
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7.发明公开Novel compound DC-107 and process for its preparation 失效Verbindung DC-107和Verfahren zu deren Herstellung。
公开(公告)号：EP0300294A2
公开(公告)日：1989-01-25
申请号：EP88110939.1
申请日：1988-07-08
发明人： Nakano, Hirofumi , Hara, Mitsunobu , Takahashi, Isami , Asano, Kozo , Iida, Takao , Morimoto, Makoto
CPC分类号： C12P1/06 , C12R1/465 , Y10S435/886
摘要： A novel compound, DC-107, is produced by culturing a microorganism belonging to the genus Streptomyces. It is useful as a medicine because of its antibacterial and anti-tumor activity.
摘要翻译： 具有以下物理化学性质的新化合物DC-107：（1）分子式：C22H26N2O6S3（2）分子量：510通过高分辨率FAB质谱求出：511.1041 C22H27N2O6S3计算值：511.1031（3）熔点：160℃ C（分解）（4）比旋光度：通过培养属于链霉菌属的微生物获得的α25_D= 140°（c = 0.1，甲醇）。 由于其抗菌和抗肿瘤活性，它作为药物是有用的。
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公开(公告)号：EP0264138A3
公开(公告)日：1988-09-14
申请号：EP87115147
申请日：1987-10-16
CPC分类号： C12R1/465 , C07D243/14 , C12P17/165
摘要： A novel compound, DC-102, having benzodiazepin nucleus is produced by culturing a microorganism belonging to the genus Streptomyces . It is useful as a medicine because of its antibacterial and anti-tumor activities.
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