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13 条记录 (耗时 0.016 秒)

    PROPENONE DERIVATIVE
    1.
    发明公开
    PROPENONE DERIVATIVE 失效
    PROPENON衍。

    公开(公告)号：EP0680950A1

    公开(公告)日：1995-11-08

    申请号：EP95900905.1

    申请日：1994-11-16

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： IKEDA, Shun-ichi ,  KIMURA, Uichiro ,  ASHIZAWA, Tadashi ,  GOMI, Katsushige ,  SAITO, Hiromitsu ,  KASAI, Masaji

    IPC分类号： C07D209/12 ,  C07D209/30 ,  C07D401/06 ,  A61K31/40 ,  A61K31/44 ,  C07D405/06

    CPC分类号： C07D401/06 ,  C07D209/12 ,  C07D209/30 ,  C07D405/06

    摘要： A propenone derivative represented by general formula (I) and a pharmacologically acceptable salt thereof, wherein R¹ represents hydrogen, lower alkyl, lower alkanoyl, lower alkoxycarbonyl, lower alkylsulfonyl, aralkyl, (un)substituted aroyl, (un)substituted arylsulfonyl, (un)substituted heteroarylcarbonyl, (un)substituted heteroarylsulfonyl, diglycolyl or a group of formula (a), R² represents hydrogen, lower alkyl, halogen, (un)substituted aryl or (un)substituted heteroaryl; R³ represents hydrogen, lower alkyl or (un)substituted aryl; and R⁴, R⁵, R⁶ and R⁷ represent each independently hydrogen, lower alkyl, lower alkoxy, aralkyloxy, hydroxy, nitro, halogen, trifluoromethyl or -NR⁸R⁹, wherein R⁸ and R⁹ represent each independently hydrogen, lower alkyl, lower alkanoyl, lower alkoxycarbonyl or (un)substituted aroyl.

    摘要翻译： 由通式（I）表示的丙烯酮衍生物及其药理学可接受的盐，其中R 1表示氢，低级烷基，低级烷酰基，低级烷氧基羰基，低级烷基磺酰基，芳烷基，（未）取代的芳酰基，（取代的）取代的芳基磺酰基 ，（un）取代的杂芳基羰基，（un）取代的杂芳基磺酰基，二油基或式（a）的基团，R 2表示氢，低级烷基，卤素，（取代的）取代的芳基或（未）取代的杂芳基; R 3表示氢，低级烷基或（取代）取代的芳基; 和R 4，R 5，R 6和R 7分别独立地表示氢，低级烷基，低级烷氧基，芳烷氧基，羟基，硝基，卤素，三氟甲基或-NR 8 R 9。 其中R 8和R 9各自独立地表示氢，低级烷基，低级烷酰基，低级烷氧基羰基或（取代的）取代的芳酰基。

    DC107 DERIVATIVES
    3.
    发明公开
    DC107 DERIVATIVES 失效
    推出冯DC 107

    公开(公告)号：EP0786462A1

    公开(公告)日：1997-07-30

    申请号：EP96917696.5

    申请日：1996-06-14

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： KANDA, Yutaka ,  SAITOH, Yutaka ,  SAITO, Hiromitsu ,  ASHIZAWA, Tadashi ,  SUGIYAMA, Kazuyo ,  GOMI, Katsushige ,  KAKITA, Shingo ,  TAKAHASHI, Yuichi ,  MURAKATA, Chikara

    IPC分类号： C07D513/08 ,  A61K31/425

    CPC分类号： C07D513/08

    摘要： DC107 derivatives represented by the formula (I):
    or pharmacologically acceptable slats thereof,
    [wherein R 1 is hydrogen, lower alkoxyalkyl, aralkyloxyalkyl, lower alkoxyalkoxyalkyl, lower alkoxyalkoxyalkoxyalkyl, aralkyl, tetrahydropyranyl, COR 4 or the like; R 2 represents hydrogen or COR 5 ; R 3 represents lower alkyl, lower alkenyl, aralkyl which may be substituted with substituted or unsubstituted aryl, lower alkoxyalkyl, aralkyloxyalkyl, substituted or unsubstituted aryloxyalkyl, lower alkoxycarbonylalkyl, lower alkanoyloxyalkyl, alicyclic alkanoyloxyalkyl or the like, or bonds to Y to represent a single bond; Y bonds to R 3 to represent a single bond, or bonds to Z to represent a single bond; Z represents hydrogen or bonds to Y to represent a single bond; W represents oxygen or NR 6 , with the proviso that the compound wherein R 1 , R 2 and Z each represents hydrogen, R 3 bonds to Y to represent a single bond, and W represents oxygen (DC107) is excluded.]

    摘要翻译： 由式（I）代表的DC107衍生物：其或其药理学上可接受的板条，其中R 1是氢，低级烷氧基烷基，芳烷氧基烷基，低级烷氧基烷氧基烷基，低级烷氧基烷氧基烷氧基烷基，芳烷基，四氢吡喃基，COR 4等; R 2表示氢或COR 5; R 3表示低级烷基，低级烯基，可被取代或未取代的芳基取代的芳烷基，低级烷氧基烷基，芳烷氧基烷基，取代或未取代的芳氧基烷基，低级烷氧基羰基烷基，低级烷酰氧基烷基，脂环族烷酰氧基烷基等，或与Y键合以表示 单一债券 Y与R 3键合以表示单键，或与Z键合以表示单键; Z表示氢或与Y键合以表示单键; W表示氧或NR 6，条件是其中R 1，R 2和Z各自表示氢，R 3与Y键合以表示单键，W表示氧（DC107 ）被排除在外

    DC 107 DERIVATIVES (2)
    4.
    发明公开
    DC 107 DERIVATIVES (2) 失效
    DC 107-DERIVATE

    公开(公告)号：EP0887351A1

    公开(公告)日：1998-12-30

    申请号：EP97947917.7

    申请日：1997-12-12

    申请人： Kyowa Hakko Kogyo Co., Ltd.

    发明人： KANDA, Yutaka ,  ARAI, Hitoshi ,  YAMAGUCHI, Hiroyuki ,  ASHIZAWA, Tadashi ,  IKEDA, Shun-ichi ,  MURAKATA, Chikara ,  TAMAOKI, Tatsuya

    IPC分类号： C07D513/18 ,  C07D513/20 ,  C07D519/00 ,  C07H15/26 ,  C07H17/00 ,  A61K31/425 ,  A61K31/70

    CPC分类号： C07D513/08 ,  C07H15/26 ,  C07H17/02

    摘要： DC107 derivatives represented by formula (I) or pharmaceutically acceptable salts thereof which have antimicrobial activity and antitumor activity are provided:
    wherein R 1 represents CO(CR 4A R 4B ) n1 (O(CH 2 ) p1 ) n2 OR 5 {wherein n1 represents an integer of 1 or 2; R 4A and R 4B are the same or different, and each represents hydrogen or lower alkyl; p1 and n2 each represents an integer of 1 to 10; and R 5 represents hydrogen, lower alkyl, or the like), or
    (wherein A 1 , A 2 , A 3 , and A 4 are the same or different, and each represents hydrogen, hydroxy, or the like); R 2 represents hydrogen or COR 6 (wherein R 6 represents lower alkyl, aralkyl, substituted or unsubstituted aryl, or the like); R 3 represents lower alkyl, lower alkenyl, aralkyl having substituted or unsubstituted aryl, alicyclic alkanoyloxyalkyl, -CH 2 OCOR 7 , or the like, or is combined with Y to represent a bond; Y is combined together with R 3 to represent a bond or is combined together with Z to represent a bond; Z represents hydrogen, or is combined together with Y to represent a bond; and W represents oxygen, or NR 8 .

    摘要翻译： 提供了具有抗微生物活性和抗肿瘤活性的由式​​（I）表示的DC107衍生物或其药学上可接受的盐：其中R 1表示CO（CR 4 R 4）n1（O（CH 2）p1） ）n2OR <5>其中n1表示1或2的整数; R 4A和R 4B相同或不同，各自表示氢或低级烷基; p1和n2各自表示1〜10的整数， R 5表示氢，低级烷基等）或（其中A 1，A 2，A 3和A 4相同或不同，各自 表示氢，羟基等）; R 2表示氢或COR 6（其中R 6表示低级烷基，芳烷基，取代或未取代的芳基等）; R 3表示低级烷基，低级烯基，具有取代或未取代的芳基的芳烷基，脂环族烷酰氧基烷基，-CH 2 OCOR 7等，或与Y结合以表示键; Y与R 3结合以表示键或与Z结合以表示键; Z表示氢，或与Y结合表示键; W表示氧，或NR 8。

    PROPENONE DERIVATIVES
    5.
    发明公开
    PROPENONE DERIVATIVES 失效
    丙烯衍生物

    公开(公告)号：EP0770601A1

    公开(公告)日：1997-05-02

    申请号：EP96912261.3

    申请日：1996-04-26

    申请人： Kyowa Hakko Kogyo Co., Ltd.

    发明人： IKEDA, Shun-ichi ,  KANAZAWA, Junji ,  GOMI, Katsushige ,  SAITO, Hiromitsu ,  ASHIZAWA, Tadashi

    IPC分类号： C07D209/12 ,  C07D405/10 ,  A61K31/40

    CPC分类号： C07D405/06 ,  C07D209/12

    摘要： The present invention relates to propenone derivatives represented by the following formula (I):
    wherein R 1 represents hydrogen or lower alkyl; R 2 and R 3 independently represent hydrogen, lower alkyl, or substituted or unsubstituted aralkyl, or alternatively R 2 and R 3 are combined to form substituted or unsubstituted methylene or ethylene; R 4 represents hydrogen, hydroxy, lower alkyl, substituted or unsubstituted aralkyl, lower alkoxy, substituted or unsubstituted aralkyloxy, or halogen; and X represents substituted or unsubstituted indolyl, with the proviso that when OR 3 is on the position 2 or position 6 of the benzene ring, R 3 is not hydrogen; that when R 4 is on the position 2 or position 6 of the benzene ring, R 4 is not hydroxy; and that the combination of OR 2 , OR 3 , and R 4 is not 3,4-dimethoxy or 3,4,5-trimethoxy; or pharmaceutically acceptable salts thereof.

    DC 107 DERIVATIVES (1)
    7.
    发明公开
    DC 107 DERIVATIVES (1) 失效
    DC 107 DERIVATE（1）

    公开(公告)号：EP0918058A1

    公开(公告)日：1999-05-26

    申请号：EP97947916.9

    申请日：1997-12-12

    申请人： KYOWA HAKKO KOGYO CO., Ltd.

    发明人： ARAI, Hitoshi ,  KANDA, Yutaka ,  YAMAGUCHI, Hiroyuki ,  ASHIZAWA, Tadashi ,  MURAKATA, Chikara ,  IKEDA, Shun-ichi ,  TAMAOKI, Tatsuya

    IPC分类号： C07D513/18 ,  C07D519/00 ,  C07H15/26 ,  A61K31/425 ,  A61K31/70

    CPC分类号： C07D513/18 ,  C07H15/26

    摘要： DC107 derivatives represented by formula (I) or pharmaceutically acceptable salts thereof which have antimicrobial activity and antitumor activity are provided:
    wherein R 1 represents hydrogen, lower alkoxyalkyl, aralkyloxyalkyl, lower alkoxyalkoxyalkyl, lower alkoxyalkoxyalkoxyalkyl, aralkyl, tetrahydropyranyl, COR 4 , or the like; R 2 represents hydrogen or COR 6 ; R 3 represents -CH 2 OCOR 7 , phthalimidomethyl, or the like; and W represents oxygen or NR 8 (wherein R 8 represents hydroxy, lower alkoxy, lower alkenyloxy, aralkyloxy, substituted or unsubstituted arylsulfonylamino, or lower alkoxycarbonylamino).

    摘要翻译： 提供了具有抗微生物活性和抗肿瘤活性的由式​​（I）表示的DC107衍生物或其药学上可接受的盐：其中R 1表示氢，低级烷氧基烷基，芳烷氧基烷基，低级烷氧基烷氧基烷基，低级烷氧基烷氧基烷氧基烷基，芳烷基，四氢吡喃基，COR 4等; R 2表示氢或COR 6; R 3表示-CH 2 OCOR 7，邻苯二甲酰亚氨基甲基等; W表示氧或NR 8（其中R 8表示羟基，低级烷氧基，低级烯氧基，芳烷氧基，取代或未取代的芳基磺酰基氨基或低级烷氧基羰基氨基）。

    NOVEL SUBSTANCES DC-92B AND DC-92D, AND PROCESS FOR THEIR PREPARATION
    9.
    发明公开
    NOVEL SUBSTANCES DC-92B AND DC-92D, AND PROCESS FOR THEIR PREPARATION 失效
    NEUE MITTEL DC-92B UND DC-92D，SOWIE DEREN VERFAHREN ZUR HERSTELLUNG。

    公开(公告)号：EP0274545A1

    公开(公告)日：1988-07-20

    申请号：EP87904737.1

    申请日：1987-07-17

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： NAKANO, Hirofumi ,  TAKAHASHI, Isami ,  TOMITA, Fusao ,  ASANO, Kozo ,  YASUZAWA, Toru ,  ASHIZAWA, Tadashi ,  TAKAHASHI, Keiichi

    IPC分类号： C07H7/06 ,  A61K31/71 ,  C12P19/26

    CPC分类号： C07H15/12 ,  C07H17/04 ,  C12P19/26 ,  C12P19/44

    摘要： Novel compounds DC-928 and DC-92D having an an- thaquinone structure represented by planar structural formula (I) and a process for their preparation. These compounds are produced by cultivating microorganisms belonging to the genus Actinomajula. They have antibacterial and oncostatic activities, thus being useful as medicines. In the formula, R represents a group represented by the formula (II) or (III).

    摘要翻译： 式（I）的Anthra（1,2-b）吡喃类抗生素是新的。 R为（II）（抗生素DC-92B）或（III）（抗生素DC-92D）。 县。 制备方法。 包括Actinomadura（特别是Actinomadura sp.DO-92，FERM-P 1019）的菌株的培养物。 县。 抗生素为深红色固体，溶于（m）乙醇，丙酮，氯仿，乙酸乙酯，甲苯和DMSO，但可溶于无机物。 在水和己烷中。 IR，（1）1 H NMR和（13）C NMR光谱数据。