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1.发明公开Bradykinin inhibiting tripeptide derivatives, process for their preparation and pharmaceutical preparations containing them 失效Bradykininhemmende三肽衍生物，它们的制备方法和含有它们的药物组合物。
公开(公告)号：EP0009010A1
公开(公告)日：1980-03-19
申请号：EP79850071.6
申请日：1979-07-16
申请人： Kabi AB
IPC分类号： C07C103/52 , A61K37/02
CPC分类号： C07K5/0823 , C07K5/0812
摘要： Tripeptide derivatives of the formula
in which
X is selected from the group consisting of Pro and Phe
Y is selected from the group consisting of O-R, and NH-R 2 in which
R, is selected from the group consisting of straight, branched and cyclic alkyl group with 1 -12 C atoms, and
R 2 is selected from the group consisting of H, straight, branched and cyclic alkyl group with 1 - 12 C atoms, and physiologically acceptable salts thereof.
A process for producing said tripeptide derivatives by synthesis and purification methods which are known in the peptide chemistry.
Pharamaceutical preparations comprising said tripeptide derivatives.-
2.发明公开Easily split substrates for the quantification of proteases, a process for their production and a method for the quantification of proteases 失效容易切割的底物定量测定蛋白酶，为基材和测定蛋白酶的定量方法的制备方法。
公开(公告)号：EP0004256A1
公开(公告)日：1979-09-19
申请号：EP79850009.6
申请日：1979-02-06
申请人： Kabi AB
IPC分类号： C07D207/28 , C07C103/52 , C12Q1/00 , G01N33/68 , C07D311/16
CPC分类号： C07K5/0825 , C12Q1/37 , C12Q1/56 , C12Q2337/22 , C12Q2337/30 , G01N2333/96444 , G01N2333/968 , G01N2333/9723 , G01N2333/9726 , Y02P20/55 , Y10S530/802
摘要： Easily split enzyme substrates for the quantification of proteases having the general formula
wherein
R 1 = H or a protective group, preferably t-butyl-oxycarbonyl, benzyloxycarbonyl;
A, - Gly, Ala, Val, Leu, Ile. Ser, Thr, Pro, Pip, Phe or Tyr;
A 2 - Arg or Lys;
R 2 = an aromatic, possibly substituted, hydrocarbon group, wherein -NH-R 2 is a physico-chemically determinable group, preferably a chromogenic or fluorogenic group which is split by a present enzyme and then forms a cleavage product of the formula H 2 N - R 2 the amount of which can be quantified.
Process for the production of said substrates. Method in the laboratory diagnostics of proteases using said substrates.-
3.发明授权Bradykinin inhibiting tripeptide derivatives, process for their preparation and pharmaceutical preparations containing them 失效BRADYKININ抑制三磷酸腺苷衍生物，其制备方法和含有它们的药物制剂
公开(公告)号：EP0009010B1
公开(公告)日：1983-03-02
申请号：EP79850071.6
申请日：1979-07-16
申请人： Kabi AB
IPC分类号： C07C103/52 , A61K37/02
CPC分类号： C07K5/0823 , C07K5/0812
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4.发明授权
公开(公告)号：EP0004256B1
公开(公告)日：1982-07-21
申请号：EP79850009.6
申请日：1979-02-06
申请人： Kabi AB
IPC分类号： C07D207/28 , C07C103/52 , C12Q1/00 , G01N33/68 , C07D311/16
CPC分类号： C07K5/0825 , C12Q1/37 , C12Q1/56 , C12Q2337/22 , C12Q2337/30 , G01N2333/96444 , G01N2333/968 , G01N2333/9723 , G01N2333/9726 , Y02P20/55 , Y10S530/802
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