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    METHOD FOR MEASURING ABILITY TO PRODUCE EQUOL
    1.
    发明公开
    METHOD FOR MEASURING ABILITY TO PRODUCE EQUOL 审中-公开

    公开(公告)号：EP3369814A1

    公开(公告)日：2018-09-05

    申请号：EP16859981.9

    申请日：2016-10-28

    申请人： Kabushiki Kaisha Yakult Honsha

    发明人： TSUJI, Hirokazu ,  MORIYAMA, Kaoru ,  NOMOTO, Koji

    IPC分类号： C12N15/00 ,  C12N15/09 ,  C12Q1/68

    CPC分类号： C12Q1/689 ,  C12N15/00 ,  C12N15/09 ,  C12Q1/68

    摘要： The present invention provides a method for determining whether a test subject has equol-producing ability or not. A method for measuring equol-producing ability of a test subject, wherein an equol converting enzyme gene derived from enteric bacteria of a test subject is detected using three types of primer sets set forth in the following a) to c): a) a primer pair comprising an oligonucleotide having a base sequence represented by SEQ ID NO: 1 and an oligonucleotide having a base sequence represented by SEQ ID NO: 2, or a primer pair comprising complementary sequences corresponding to said base sequences, b) a primer pair comprising an oligonucleotide having a base sequence represented by SEQ ID NO: 3 and an oligonucleotide having a base sequence represented by SEQ ID NO: 4, or a primer pair comprising complementary sequences corresponding to said base sequences, c) a primer pair comprising an oligonucleotide having a base sequence represented by SEQ ID NO: 5 and an oligonucleotide having a base sequence represented by SEQ ID NO: 6 or 7, or a primer pair comprising complementary sequences corresponding to said base sequences.

    EQUOL-PRODUCING BACTERIUM AND USE THEREOF
    2.
    发明授权
    EQUOL-PRODUCING BACTERIUM AND USE THEREOF 有权
    等产细菌及其用途

    公开(公告)号：EP2402429B1

    公开(公告)日：2017-09-13

    申请号：EP10745988.5

    申请日：2010-02-25

    申请人： Kabushiki Kaisha Yakult Honsha

    发明人： TSUJI, Hirokazu ,  NOMOTO, Koji ,  MORIYAMA, Kaoru ,  AKAZA, Hideyuki

    IPC分类号： A23L33/105

    CPC分类号： C12R1/01 ,  A23L33/105 ,  A61K31/7048 ,  A61K35/74 ,  C12P17/06

    摘要： The present invention is directed to a microorganism having an ability of converting daidzein to equol in 24 hours of 50% or higher; a food/beverage or pharmaceutical composition containing the microorganism; an equol production method employing the microorganism; and a nucleic acid fragment which can specifically detect the microorganism.

    摘要翻译： 本发明涉及具有在24小时内将黄豆苷原转化为雌马酚的能力为50％或更高的微生物; 含有微生物的食物/饮料或药物组合物; 采用该微生物的雌马酚生产方法; 和可以特异性检测微生物的核酸片段。

    EQUOL LEVEL REGULATOR
    9.
    发明公开
    EQUOL LEVEL REGULATOR 有权
    雌马酚明镜-Regler公司

    公开(公告)号：EP1944021A1

    公开(公告)日：2008-07-16

    申请号：EP06822881.6

    申请日：2006-11-02

    申请人： KABUSHIKI KAISHA YAKULT HONSHA

    发明人： TSUJI, Hirokazu ,  NOMOTO, Koji ,  AKAZA, Hideyuki

    IPC分类号： A61K31/047 ,  A61K31/7004 ,  A61K31/7016 ,  A61K31/702 ,  A61P5/30 ,  A61P17/18 ,  A61P43/00 ,  C12Q1/02

    CPC分类号： C12Q1/04 ,  A23L5/00 ,  A23L21/00 ,  A23L27/33 ,  A23L29/30 ,  A23L29/37 ,  A23L33/125 ,  A61K31/047 ,  A61K31/7004 ,  A61K31/7016 ,  A61K31/702

    摘要： An object of the invention is to provide a medical drug, a food and drink having a role in regulating the concentration of equol in vivo and being capable of taking for a long time with high safety and provide a selective medium for a microorganism having conversion ability to equol and a method of detecting the same. Provided are an equol concentration-raising or reducing agent containing a carbohydrate as an active ingredient; use of a carbohydrate for producing the equol concentration-raising or reducing agent; a method of raising or reducing the concentration of equol by administrating a carbohydrate in an effective dose; a selective medium containing a carbohydrate for a microorganism having conversion ability to equol; and a method of detecting a microorganism having conversion ability to equol by use of the selective medium.

    摘要翻译： 本发明的目的在于提供一种能够在体内调节雌马酚的浓度，能够长时间高安全性地使用的药物，食品和饮料，具有转化能力的微生物的选择性培养基 至雌马酚及其检测方法。 提供含有碳水化合物作为活性成分的雌马酚浓度升高或还原剂; 使用碳水化合物制备雌马酚浓度升高或还原剂; 通过以有效剂量施用碳水化合物来提高或降低雌马酚的浓度的方法; 一种选择性培养基，其含有具有对牛尿酚转化能力的微生物的碳水化合物; 以及通过使用选择培养基检测具有牛尿酚转化能力的微生物的方法。