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公开(公告)号：EP2119785B1
公开(公告)日：2013-03-13
申请号：EP09166974.7
申请日：2000-07-24
申请人： Kangawa, Kenji
IPC分类号： C12N15/12 , C07K14/47 , C07K14/46 , C07K14/465 , C07K14/575 , A61K38/18 , A61P5/06 , A61P19/08
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a novel peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP2119785A1
公开(公告)日：2009-11-18
申请号：EP09166974.7
申请日：2000-07-24
申请人： Kangawa, Kenji
IPC分类号： C12N15/12 , C07K14/47 , C07K14/46 , C07K14/465 , C07K14/575 , A61K38/18 , A61P5/06 , A61P19/08
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a novel peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明提供了诱导生长激素分泌的新型肽型化合物，其具有增加细胞内钙离子浓度的活性，其中至少一个氨基酸被修饰的氨基酸和/或非氨基酸替代 化合物或其药学上可接受的盐。
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公开(公告)号：EP0622458A2
公开(公告)日：1994-11-02
申请号：EP94302948.8
申请日：1994-04-25
CPC分类号： C07K14/575 , A61K38/00 , C07K1/003 , C07K1/107 , C07K1/13
摘要： According to the present invention, adrenomedullin which is a novel peptide having a hypotensive effect; proadrenomedullin N-terminal 20 peptide (proAM-N20) corresponding to an amino acid sequence of an N-terminus of proadrenomedullin, having a catecholamine secretion inhibitory effect; proadrenomedullin N-terminal 10-20 peptide (proAM-N(10-20)) having a Na channel inhibitory effect, and a gene encoding these peptides are provided. In addition, according to the present invention, these peptides in a sample containing adrenomdullin or proAM-N20 in an unknown amount can be quantified by using an antibody against adrenomedullin, proAM-N20, or its fragment.
摘要翻译： 根据本发明，作为具有降血压作用的新型肽的肾上腺髓质素; 对应于具有儿茶酚胺分泌抑制作用的肾上腺髓质素的N末端氨基酸序列的前肾上腺髓质素N-末端20肽（proAM-N20） 提供具有Na通道抑制作用的前肾上腺髓质素N-末端10-20肽（proAM-N（10-20））和编码这些肽的基因。 此外，根据本发明，含有未知量的肾上腺髓质素或proAM-N20的样品中的这些肽可以通过使用针对肾上腺髓质素，proAM-N20或其片段的抗体来定量。
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公开(公告)号：EP1795598B1
公开(公告)日：2009-11-18
申请号：EP07006224.5
申请日：2000-07-24
申请人： Kangawa, Kenji
IPC分类号： C12N15/12 , C07K14/47 , C07K14/46 , C07K14/465 , C07K14/575 , C07K16/18 , C12N1/21 , C12P21/02 , A61K38/18 , A61P5/06 , A61P19/08 , A61K45/00 , A61K48/00
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a novel peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP1795598A1
公开(公告)日：2007-06-13
申请号：EP07006224.5
申请日：2000-07-24
申请人： Kangawa, Kenji
IPC分类号： C12N15/12 , C07K14/47 , C07K14/46 , C07K14/465 , C07K14/575 , C07K16/18 , C12N1/21 , C12P21/02 , A61K38/18 , A61P5/06 , A61P19/08 , A61K45/00 , A61K48/00
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a novel peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP0622458B1
公开(公告)日：2003-01-22
申请号：EP94302948.8
申请日：1994-04-25
CPC分类号： C07K14/575 , A61K38/00 , C07K1/003 , C07K1/107 , C07K1/13
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公开(公告)号：EP0622458A3
公开(公告)日：1996-06-12
申请号：EP94302948.8
申请日：1994-04-25
CPC分类号： C07K14/575 , A61K38/00 , C07K1/003 , C07K1/107 , C07K1/13
摘要： According to the present invention, adrenomedullin which is a novel peptide having a hypotensive effect; proadrenomedullin N-terminal 20 peptide (proAM-N20) corresponding to an amino acid sequence of an N-terminus of proadrenomedullin, having a catecholamine secretion inhibitory effect; proadrenomedullin N-terminal 10-20 peptide (proAM-N(10-20)) having a Na channel inhibitory effect, and a gene encoding these peptides are provided. In addition, according to the present invention, these peptides in a sample containing adrenomdullin or proAM-N20 in an unknown amount can be quantified by using an antibody against adrenomedullin, proAM-N20, or its fragment.
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