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1.发明授权INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES 有权维生素D VERBINDUNGEN ZUR BEHANDLUNG VON NEURODEGENERATIVEN ERKRANKUNGEN INDOLAMIDDERIVATE
公开(公告)号：EP2440550B1
公开(公告)日：2017-03-15
申请号：EP10728150.3
申请日：2010-06-11
发明人： GRIFFIOEN, Gerard , VAN DOOREN, Tom , ROJAS DE LA PARRA, Veronica , MARCHAND, Arnaud , ALLASIA, Sara , KILONDA, Amuri , CHALTIN, Patrick
IPC分类号： C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/4045 , A61P25/28
CPC分类号： A61K31/4045 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/635 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
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2.发明公开
公开(公告)号：EP2358682A2
公开(公告)日：2011-08-24
申请号：EP09774646.5
申请日：2009-11-16
发明人： BARDIOT, Dorothée , BLANCHE, Emilie , CHALTIN, Patrick , KOUKNI, Mohamed , LEYSSEN, Pieter , NEYTS, Johan , MARCHAND, Arnaud , VLIEGEN, Inge
IPC分类号： C07D217/24 , C07D217/26 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , A61K31/472 , A61K31/4725 , A61K31/497 , A61P31/14
CPC分类号： C07D409/04 , A61K31/472 , A61K31/4725 , A61K31/497 , C07D217/24 , C07D217/26 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention relates to a series of Isoquinolone derivatives which are suitable to treat infections with viruses belonging to the family of the Flaviviridae and more preferably infections with Hepatitis C virus (HCV). The present invention also relates to Isoquinolone compounds for use as a medicine for the prevention or treatment of viral infections, preferably infections with viruses belonging to the family of the Flaviviridae.
摘要翻译： 本发明涉及一系列适于治疗属于黄病毒科病毒感染并且更优选感染丙型肝炎病毒（HCV）的异喹诺酮衍生物。 本发明还涉及用作预防或治疗病毒感染的药物的异喹诺酮化合物，优选感染属于黄病毒科的病毒。
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3.发明公开NEW COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES 有权N - （（1H-吲哚-3-基）烷基）-4-苄基）苯甲酰胺，和N - （（1H-吡咯并[2,3-b]吡啶-3-基）烷基）-4-苄基） 苯甲酰胺衍生物作为α-突触核蛋白聚集抑制剂用于治疗神经变性疾病的治疗
公开(公告)号：EP2651888A1
公开(公告)日：2013-10-23
申请号：EP11805450.1
申请日：2011-12-13
发明人： GRIFFIOEN, Gerard , VAN DOOREN, Tom , ROJAS DE LA PARRA, Verónica , ALLASIA, Sara , MARCHAND, Arnaud , KILONDA, Amuri , CHALTIN, Patrick
IPC分类号： C07D209/14 , C07D471/04 , C07D403/12 , C07D405/12 , C07D409/12 , A61K31/4045 , A61P25/28 , A61P25/16
CPC分类号： C07D209/14 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterised by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds. The compounds have the formula (A1) wherein R
1 , R
2 , R
4 , R
6 , E, n, Y
1 , Y
2 , Y
3 , Y
4 , Y
5 , L, B, R
8 , and m are as defined in the claims.-
4.发明公开NOVEL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES 有权N-（2-（5-取代的-1H-吲哚-3-基）乙基）联苯-4-甲酰胺衍生物和相关化合物作为τ聚集诱导的毒性抑制剂的神经变性疾病的治疗
公开(公告)号：EP2651887A1
公开(公告)日：2013-10-23
申请号：EP11804532.7
申请日：2011-12-13
发明人： GRIFFIOEN, Gerard , VAN DOOREN, Tom , ROJAS DE LA PARRA, Verónica , MARCHAND, Arnaud , ALLASIA, Sara , KILONDA, Amuri , CHALTIN, Patrick
IPC分类号： C07D209/14 , C07D471/04 , A61K31/4045 , A61P25/28 , A61P25/16
CPC分类号： C07D209/18 , C07D209/14 , C07D401/12 , C07D409/12 , C07D471/04
摘要： This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterised by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds. The compounds have the formula (A1), wherein R
1 , R
2 , R
4 , R
5 , R
6 , E, n, Y
1 , Y
2 , Y
3 , Y
4 , Y
5 , B, R
8 , and m are as defined in the claims.-
5.发明公开INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES 有权INDOLAMIDDERIVATE和神经退行性疾病的治疗相关的化合物
公开(公告)号：EP2440550A1
公开(公告)日：2012-04-18
申请号：EP10728150.3
申请日：2010-06-11
发明人： GRIFFIOEN, Gerard , VAN DOOREN, Tom , ROJAS DE LA PARRA, Veronica , MARCHAND, Arnaud , ALLASIA, Sara , KILONDA, Amuri , CHALTIN, Patrick
IPC分类号： C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/4045 , A61P25/28
CPC分类号： A61K31/4045 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/635 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterised by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds.
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