公开(公告)号：EP4374914A1

公开(公告)日：2024-05-29

申请号：EP22845958.2

申请日：2022-07-20

申请人： Kyoto University

发明人： EIRAKU, Mototsugu

IPC分类号： A61P9/10 ,  A61P27/02 ,  C12M3/00 ,  C12N5/07 ,  C12N5/0735 ,  C12N5/10 ,  A61K35/30 ,  A61L27/38 ,  A61L27/40 ,  C07K14/78

CPC分类号： A61K35/30 ,  A61L27/38 ,  A61L27/40 ,  A61P9/10 ,  A61P27/02 ,  C07K14/78 ,  C12M3/00 ,  C12N5/06 ,  C12N5/10

摘要： The present disclosure includes a method of producing a retinal tissue, comprising inducing differentiation of pluripotent stem cells into a retinal tissue on a surface of a culture substrate, wherein the culture substrate comprises a region A and a region B on the surface, the differentiation is induced is the region A, the region A has cell adhesiveness, and the region B is adjacent to at least a part of the region A and has cell adhesiveness lower than the cell adhesiveness of the region A; a retinal tissue produced by the method; and a composition comprising the retinal tissue.