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公开(公告)号：EP2638060A2
公开(公告)日：2013-09-18
申请号：EP11784463.9
申请日：2011-11-10
申请人： LABORATORIOS DEL DR. ESTEVE, S.A. , Fundació Privada Institut de Recerca de la SIDA-Caixa , Institució Catalana de Recerca i Estudis Avançats , University of Washington
CPC分类号： A61K39/21 , A61K38/00 , A61K39/12 , A61K2039/572 , C07K7/08 , C07K14/005 , C12N7/00 , C12N2740/16021 , C12N2740/16034 , C12N2740/16071 , C12N2740/16222 , C12N2740/16234 , G01N33/505 , G01N2333/161
摘要： The invention relates to peptides comprising part or all of a conserved element within a Center-of Tree (COT) sequence derived from a family of polypeptides encoded by naturally occurring variants of HIV. The invention also relates to immunogenic compositions and vaccines comprising said peptides. The invention also relates to methods for the identification of HIV controller patients based on the detection of the T cells of the patient to mount a cytotoxic T cell response against said peptides and to methods for the identification of immunogenic peptides within a family of variant polypeptides.
摘要翻译： 本发明涉及包含部分或全部保护元件的肽，所述保守元件来源于由天然存在的HIV变异体编码的多肽家族的树中（COT）序列。 本发明还涉及包含所述肽的免疫原性组合物和疫苗。 本发明还涉及基于检测患者的T细胞以鉴定针对所述肽的细胞毒性T细胞应答以及用于鉴定变体多肽家族内的免疫原性肽的方法来鉴定HIV控制患者的方法。
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公开(公告)号：EP3205662A3
公开(公告)日：2017-11-01
申请号：EP17162645.0
申请日：2011-11-10
申请人： Laboratorios del Dr. Esteve S.A. , Fundació Privada Institut de Recerca de la SIDA-Caixa , Institució Catalana de Recerca i Estudis Avançats , University of Washington
CPC分类号： A61K39/21 , A61K38/00 , A61K39/12 , A61K2039/572 , C07K7/08 , C07K14/005 , C12N7/00 , C12N2740/16021 , C12N2740/16034 , C12N2740/16071 , C12N2740/16222 , C12N2740/16234 , G01N33/505 , G01N2333/161
摘要： The invention relates to peptides comprising part or all of a conserved element within a Center-of Tree (COT) sequence derived from a family of polypeptides encoded by naturally occurring variants of HIV. The invention also relates to immunogenic compositions and vaccines comprising said peptides. The invention also relates to methods for the identification of HIV controller patients based on the detection of the T cells of the patient to mount a cytotoxic T cell response against said peptides and to methods for the identification of immunogenic peptides within a family of variant polypeptides.
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公开(公告)号：EP3205662A2
公开(公告)日：2017-08-16
申请号：EP17162645.0
申请日：2011-11-10
申请人： Laboratorios del Dr. Esteve S.A. , Fundació Privada Institut de Recerca de la SIDA-Caixa , Institució Catalana de Recerca i Estudis Avançats , University of Washington
CPC分类号： A61K39/21 , A61K38/00 , A61K39/12 , A61K2039/572 , C07K7/08 , C07K14/005 , C12N7/00 , C12N2740/16021 , C12N2740/16034 , C12N2740/16071 , C12N2740/16222 , C12N2740/16234 , G01N33/505 , G01N2333/161
摘要： The invention relates to peptides comprising part or all of a conserved element within a Center-of Tree (COT) sequence derived from a family of polypeptides encoded by naturally occurring variants of HIV. The invention also relates to immunogenic compositions and vaccines comprising said peptides. The invention also relates to methods for the identification of HIV controller patients based on the detection of the T cells of the patient to mount a cytotoxic T cell response against said peptides and to methods for the identification of immunogenic peptides within a family of variant polypeptides.
摘要翻译： 本发明涉及包含衍生自天然存在的HIV变体编码的多肽家族的中心树（COT）序列内的部分或全部保守元件的肽。 本发明还涉及包含所述肽的免疫原性组合物和疫苗。 本发明还涉及基于检测患者的T细胞以产生针对所述肽的细胞毒性T细胞应答来鉴定HIV控制患者的方法，以及鉴定变体多肽家族内的免疫原性肽的方法。
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4.发明公开METHOD FOR MONITORING HIV SPECIFIC T CELL RESPONSES 有权VERFAHREN ZURÜBERWACHUNGHIV-SPEZIFISCHER T-ZELL-ANTWORTEN
公开(公告)号：EP2828656A1
公开(公告)日：2015-01-28
申请号：EP13711681.0
申请日：2013-03-22
申请人： LABORATORIOS DEL DR. ESTEVE, S.A. , Fundació Privada Institut de Recerca de la SIDA-Caixa , Institució Catalana de Recerca i Estudis Avançats
IPC分类号： G01N33/50 , G01N33/569
摘要： The invention relates to a method and a diagnostic kit for monitoring HIV specific T cell responses and identifying subjects capable of controlling HIV progression or preventing HIV infection altogether. The method is based on the combined use of boosted flow cytometry and toggle peptides and can cover a large set of effector functions. The method is also suitable to detect T cell responses of any desirable cytokine or combination of cytokines to any pathogen.
摘要翻译： 本发明涉及用于监测HIV特异性T细胞应答的方法和诊断试剂盒，并鉴定能够控制HIV进展或完全预防HIV感染的受试者。 该方法基于加强流式细胞术和切换肽的组合使用，并且可以覆盖比标准测定法更大的一组效应子功能。 该方法还适用于检测任何所需细胞因子或细胞因子组合对任何病原体的T细胞应答
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公开(公告)号：EP2807185A2
公开(公告)日：2014-12-03
申请号：EP13701288.6
申请日：2013-01-28
申请人： Laboratorios del. Dr. Esteve, S.A. , Fundació Privada Institut de Recerca de la SIDA-Caixa , Institució Catalana de Recerca i Estudis Avançats
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/57 , A61K2039/575 , C07K2319/35 , C12N7/00 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates to novel immunogens based on overlapping peptides (OLPs) and peptides derived therefrom useful for the prevention and treatment of AIDS and its related opportunistic diseases. The invention also relates to isolated nucleic acids, vectors and host cells expressing these immunogens as well as vaccines including said immunogens.
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公开(公告)号：EP4163290A1
公开(公告)日：2023-04-12
申请号：EP22195110.6
申请日：2013-01-28
摘要： The present invention relates to novel immunogens based on overlapping peptides (OLPs) and peptides derived therefrom useful for the prevention and treatment of AIDS and its related opportunistic diseases. The invention also relates to isolated nucleic acids, vectors and host cells expressing these immunogens as well as vaccines including said immunogens.
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