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1.发明授权A PHARMACEUTICAL SPRAY COMPOSITION COMPRISING A VITAMIN D ANALOGUE AND A CORTICOSTEROID 有权药物含维生素D和皮质类固醇的喷雾制剂类似物
公开(公告)号：EP2579852B1
公开(公告)日：2014-12-31
申请号：EP11726055.4
申请日：2011-06-10
申请人： Leo Pharma A/S
CPC分类号： A61K31/593 , A61K9/0014 , A61K9/122 , A61K9/124 , A61K31/573 , A61K31/58 , A61K31/59 , A61K47/06 , A61K47/08 , A61K47/14 , A61K47/22 , A61M11/00 , A61M35/003 , A61M2210/04 , B65D83/207 , B65D83/752 , A61K2300/00
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公开(公告)号：EP2515874B1
公开(公告)日：2014-08-20
申请号：EP10803440.6
申请日：2010-12-22
申请人： Leo Pharma A/S
发明人： PETERSSON, Karsten
IPC分类号： A61K9/00 , A61K9/14 , A61K31/593
CPC分类号： A61K31/592 , A61K9/0014 , A61K9/06 , A61K9/146 , A61K31/593 , A61K45/06 , C07C35/21 , Y10T428/2982
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3.发明公开A PHARMACEUTICAL SPRAY COMPOSITION COMPRISING A VITAMIN D ANALOGUE AND A CORTICOSTEROID 有权医药保健品SPRÜHZUBEREITUNGENTHALTEND EIN ANALOGA VON维生素D
公开(公告)号：EP2579852A1
公开(公告)日：2013-04-17
申请号：EP11726055.4
申请日：2011-06-10
申请人： Leo Pharma A/S
CPC分类号： A61K31/593 , A61K9/0014 , A61K9/122 , A61K9/124 , A61K31/573 , A61K31/58 , A61K31/59 , A61K47/06 , A61K47/08 , A61K47/14 , A61K47/22 , A61M11/00 , A61M35/003 , A61M2210/04 , B65D83/207 , B65D83/752 , A61K2300/00
摘要： The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative and a corticosteroid, and its use in the treatment of dermal diseases and conditions. The spray comprises especially a propellant selected freom the group consisting of dimethyl ether, diethyl ether and methylethyl ether or a mixture thereof and further a pharmaceutically acceptable lipid carrier solubilised or suspended in said propellant.
摘要翻译： 本发明涉及包含卡泊三醇或卡泊三醇一水合物和治疗有效量的二丙酸倍他米松的局部喷雾组合物，其溶解在包含二甲醚作为第一推进剂和第二推进剂的药学上可接受的推进剂混合物中，所述推进剂混合物选自C3- 5烷烃，氢氟烷烃，氢氯代烷烃，氟代烷烃和氯氟烷烃，该组合物还包含溶解或悬浮在所述推进剂混合物中的药学上可接受的脂质载体。
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4.发明公开A TOPICAL COMPOSITION COMPRISING A FILM-FORMING POLYMER FOR DELIVERING AN ACTIVE INGREDIENT TO SKIN 审中-公开一种包含成膜聚合物的用于将活性成分递送至皮肤的局部组合物
公开(公告)号：EP2900211A1
公开(公告)日：2015-08-05
申请号：EP13737817.0
申请日：2013-07-05
申请人： Leo Pharma A/S
CPC分类号： A61K31/573 , A61K9/0014 , A61K9/124 , A61K9/7015 , A61K47/06 , A61K47/08 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/26 , A61K47/32 , A61K47/38 , A61K47/44 , B65D83/752
摘要： A film-forming pharmaceutical composition for dermal application comprises at least one therapeutically active ingredient dissolved in a volatile solvent, the composition further comprising a film-forming polymer, a plasticizer and an oily release-enhancing agent. The composition is capable of forming, after application on skin and evaporation of the solvent, a continuous phase comprising the film-forming polymer and the plasticizer and a dispersed phase comprising droplets of the oily release-enhancing agent.
摘要翻译： 用于皮肤施用的可喷雾成膜药物组合物包含至少一种溶解于选自二甲醚，二乙醚和甲基乙基醚的药学上可接受的推进剂中的治疗活性成分以及二甲醚，二乙基醚和甲基乙基醚的混合物，和 选自C 3-5烷烃，氢氟烷烃，氢氯烷烃，氟烷烃和氯氟烷烃的第二推进剂，推进剂以组合物的50-99.5％w / w的量存在，所述组合物还包含成膜聚合物，增塑剂 和油性释放增强剂。
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5.发明公开A TOPICAL COMPOSITION COMPRISING A FILM-FORMING POLYMER FOR DELIVERING AN ACTIVE INGREDIENT TO SKIN 审中-公开与薄膜状的最终聚合物局部用组合物作出积极在皮肤
公开(公告)号：EP2900210A1
公开(公告)日：2015-08-05
申请号：EP13734410.7
申请日：2013-07-05
申请人： Leo Pharma A/S
CPC分类号： A61K31/573 , A61K9/0014 , A61K9/124 , A61K9/7015 , A61K47/06 , A61K47/08 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/26 , A61K47/32 , A61K47/38 , A61K47/44 , B65D83/752
摘要： A film-forming pharmaceutical composition for dermal application comprises at least one therapeutically active ingredient dissolved in a volatile solvent, the composition further comprising a film-forming polymer, a plasticizer and an oily release-enhancing agent. The composition is capable of forming, after application on skin and evaporation of the solvent, a continuous phase comprising the film-forming polymer and the plasticizer and a dispersed phase comprising droplets of the oily release-enhancing agent.
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6.发明公开CUTANEOUS COMPOSITION COMPRISING VITAMIN D ANALOGUE AND A MIXTURE OF SOLVENT AND SURFACTANTS 有权成分与维生素D类似物皮肤和溶剂和表面活性剂混合物
公开(公告)号：EP2515865A2
公开(公告)日：2012-10-31
申请号：EP10803218.6
申请日：2010-12-22
申请人： Leo Pharma A/S
发明人： PETERSSON, Karsten
CPC分类号： A61K31/592 , A61K9/0014 , A61K9/1075 , A61K31/593 , A61K47/06 , A61K47/14 , A61K47/18 , A61K47/44
摘要： A pharmaceutical composition comprising a vitamin D derivative or analogue as the active ingredient dissolved in a three-component surfactant-solvent mixture is useful in the treatment of dermal disorders or conditions.
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7.发明公开
公开(公告)号：EP3273942A1
公开(公告)日：2018-01-31
申请号：EP16720351.2
申请日：2016-03-16
申请人： Leo Pharma A/S
发明人： PETERSSON, Karsten , ENGELL, Karen Margrethe , JANSSON, Jörgen , NIELSEN, Kim Troensegaard , ERIKSSON, André Huss , MOORE, Anne , VUCEN, Sonja , O'SULLIVAN, Caroline , CREAN, Abina
IPC分类号： A61K9/00 , A61K31/593 , A61K31/661
CPC分类号： A61K9/0021 , A61K31/573 , A61K31/59 , A61K31/593 , A61K47/32 , A61K47/34 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61M2037/0061 , A61K2300/00
摘要： The present invention relates to a microneedle patch composition comprising one or more microneedles each comprising: (a) a tapered tip portion containing a therapeutically active ingredient dispersed in a matrix of a biodegradable polymer capable of providing sustained release of the therapeutically active ingredient over a period of at least two days after insertion of the microneedle or microneedles into the skin, and (b) a fast dissolving microneedle backing layer portion containing a water-soluble polymer overlayering the tip portion, said microneedle or microneedles being attached to and extending from an adhesive surface of a removable substrate.
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8.发明公开PHARMACEUTICAL COMPOSITION COMPRISING VITAMIN D ANALOGUE AND COSOLVENT-SURFACTANT MIXTURE 审中-公开与维生素D类似物和共溶剂 - 表面活性剂混合物的药物组合物
公开(公告)号：EP2515912A1
公开(公告)日：2012-10-31
申请号：EP09852472.1
申请日：2009-12-22
申请人： Leo Pharma A/S
发明人： PETERSSON, Karsten
CPC分类号： A61K9/0014 , A61K9/113 , A61K31/192 , A61K31/405 , A61K31/54 , A61K31/573 , A61K31/59 , A61K45/06 , A61K2300/00
摘要： A topical pharmaceutical composition which is an oil-in-water-oil emulsion comprising a vitamin D derivative or analogue dissolved in a mixture of a non-ionic surfactant and a lower alkanol. The topical pharmaceutical composition may be used in the treatment of dermal conditions, such as psoriasis.
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9.发明授权PHARMACEUTICAL COMPOSITION COMPRISING SOLVENT MIXTURE AND A VITAMIN D DERIVATIVE OR ANALOGUE 有权用溶剂混合物和维生素D衍生物或类似物的药物组合物
公开(公告)号：EP2515866B1
公开(公告)日：2014-02-19
申请号：EP10803219.4
申请日：2010-12-22
申请人： Leo Pharma A/S
发明人： PETERSSON, Karsten
CPC分类号： A61K31/593 , A61K9/0014 , A61K9/06 , A61K47/10 , A61K47/14 , A61K47/22
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10.发明公开PHARMACEUTICAL COMPOSITION COMPRISING SOLVENT MIXTURE AND A VITAMIN D DERIVATIVE OR ANALOGUE 有权用溶剂混合物和维生素D衍生物或类似物的药物组合物
公开(公告)号：EP2515866A2
公开(公告)日：2012-10-31
申请号：EP10803219.4
申请日：2010-12-22
申请人： Leo Pharma A/S
发明人： PETERSSON, Karsten
IPC分类号： A61K9/06 , A61K31/593 , A61K47/10 , A61K47/14 , A61K47/22
CPC分类号： A61K31/593 , A61K9/0014 , A61K9/06 , A61K47/10 , A61K47/14 , A61K47/22
摘要： A substantially anhydrous, topical pharmaceutical composition comprising a non¬ alcoholic three-component solvent mixture and a biologically active vitamin D derivative or analogue dissolved therein as well as a pharmaceutically acceptable carrier may be used in the treatment of dermal conditions.
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