公开(公告)号：EP1744620A2

公开(公告)日：2007-01-24

申请号：EP05736493.7

申请日：2005-04-12

申请人： GENENTECH, INC. ,  Lexicon Genetics Incorporated

发明人： BRENNAN, Jane ,  DESAUVAGE, Frederic ,  EDWARDS, Joel ,  FILVAROFF, Ellen ,  GREWAL, Iqbal ,  HUANG, Wenhu ,  IRVING, Bryan ,  JUNUTULA, Jagath Reddy ,  KIRCHHOFER, Daniel J. ,  MONTGOMERY, Chuck ,  PAYNE, Bobby Joe ,  PEALE JR., Franklin ,  PHILLIPS, Heidi ,  QIAN, Ni Nancy ,  SHI, Zheng-Zheng ,  SPARKS, Mary Jean ,  STALA, Joy ,  TANG, Tracy Tzu-Ling ,  VOGEL, Peter ,  YE, Weilan

IPC分类号： A01K67/027 ,  C12N15/85 ,  G01N33/50 ,  C12N5/10 ,  C12N15/12 ,  C12N15/15 ,  C12N15/24 ,  C12N15/52 ,  C12N15/55 ,  C12N15/57 ,  A61K49/00

CPC分类号： A01K67/0275 ,  A01K67/0278 ,  A01K2217/05 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  A61K49/0008 ,  C07K14/4703 ,  C07K14/705 ,  C12N15/8509

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO256, PRO34421, PRO334, PRO770, PRO983, PRO1009, PRO1107, PRO1158, PRO1250, PRO1317, PRO4334, PRO4395, PRO49192, PRO9799, PRO21175, PRO19837, PRO21331, PRO23949, PRO697 or PRO1480 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

公开(公告)号：EP1781824A2

公开(公告)日：2007-05-09

申请号：EP05793413.5

申请日：2005-08-23

申请人： GENENTECH, INC. ,  Lexicon Genetics Incorporated

发明人： BRENNAN, Jane ,  DESAUVAGE, Frederic ,  EDWARDS, Joel ,  HUANG, Wenhu ,  MONTGOMERY, Chuck ,  PAYNE, Bobby Joe ,  SHI, Zheng-Zheng ,  SPARKS, Mary Jean ,  VOGEL, Peter ,  YE, Weilan

IPC分类号： C12Q1/68

CPC分类号： A01K67/0276 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/02 ,  A01K2267/03 ,  C12N15/8509

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO196, PRO217, PRO231, PRO236, PRO245, PRO246, PRO258, PRO287, PRO328, PRO344, PRO357, PRO526, PRO724, PRO731, PRO732, PRO1003, PRO1104, PRO1151, PRO1244, PRO1298, PRO1313, PRO1570, PRO1886, PRO1891, PRO4409, PRO5725, PRO5994, PRO6097, PRO7425, PRO10102, PRO10282, PRO61709 or PRO779 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

公开(公告)号：EP1694116A2

公开(公告)日：2006-08-30

申请号：EP04813966.1

申请日：2004-12-13

申请人： GENENTECH, INC. ,  Lexicon Genetics Incorporated

发明人： ANDERSON, Stephen ,  BRENNAN, Jane ,  DESAUVAGE, Frederic ,  DING, Zhiyong ,  EDWARDS, Joel ,  FIKES, Nelda ,  HUANG, Wenhu ,  OUYANG, Wenjun ,  RANGEL, Carolina ,  SANGHA, Mamta ,  SHI, Zheng-Zheng ,  SPARKS, Mary Jean ,  TRACKEY, Joseph ,  VETTER, Melissa ,  WANG, Ching-Yun ,  WOODINGS, Jessica

IPC分类号： A01K67/027

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0306

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO224, PRO9783, PRO1108, PRO34000, PRO240, PRO943, hu A33, PRO230, PRO178, PRO1199, PRO4333, PRO1336, PRO19598, PRO1083, hu TRPM2 or PRO1801 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

公开(公告)号：EP1713325A2

公开(公告)日：2006-10-25

申请号：EP05712242.6

申请日：2005-01-27

申请人： Lexicon Genetics Incorporated

发明人： EDWARDS, Joel ,  HUANG, Wenhu ,  MONTGOMERY, Chuck ,  QIAN, Ni Nancy ,  SHI, Zheng-Zheng ,  SPARKS, Mary Jean ,  VOGEL, Peter ,  WESTBROOK, Mindy

IPC分类号： A01K67/027 ,  C07K14/47

CPC分类号： C07K14/47 ,  A01K2217/075

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO227, PRO233, PRO238, PRO1328, PRO4342, PRO7423, PRO10096, PRO21384, PRO353 or PRO1885 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

公开(公告)号：EP2046965A2

公开(公告)日：2009-04-15

申请号：EP07863348.4

申请日：2007-05-21

申请人： Genentech, Inc. ,  Lexicon Pharmaceuticals, Inc.

发明人： DESAUVAGE, Frederic ,  FILVAROFF, Ellen ,  JUNUTULA, Jagath, Reddy ,  PAYNE, Bobby, Joe ,  SHI, Zheng-zheng ,  SPARKS, Mary Jean ,  VOGEL, Peter

IPC分类号： C12N15/85 ,  A01K67/027 ,  G01N33/53 ,  C07K14/47 ,  C07K16/18

CPC分类号： G01N33/5088 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0306 ,  A01K2267/035 ,  C07K14/47 ,  C12N15/8509 ,  G01N33/6893 ,  G01N2500/00

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO844, PRO1131 or PRO5992 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

公开(公告)号：EP1922410A2

公开(公告)日：2008-05-21

申请号：EP06787655.7

申请日：2006-07-18

申请人： Genentech, Inc. ,  Lexicon Pharmaceuticals, Inc.

发明人： HORNER, Allison Anne Byers ,  COMBS, Katherin, E. ,  CULBERTSON, Ling Ling ,  DELMAS-MATA, Juan ,  DESAUVAGE, Frederic ,  FAN, Liangfen ,  FRANTZ, Gretchen ,  GREEN, Leslie Jane ,  MASSEY, Erin Marie ,  MCLAIN, Dina Rebecca ,  MONTGOMERY, Charles A. ,  PAYNE, Bobby Joe ,  PEALE, Franklin, Jr. ,  PHILLIPS, Heidi ,  ROHRER, Michelle ,  SHI, Zheng-Zheng ,  SPARKS, Mary Jean ,  STALA, Joy Anne ,  TANG, Tracy Tzu-Ling ,  VOGEL, Peter ,  WANG, Ching-Yun ,  SEVAUX, Tracy Ellen Willis ,  XIONG, Wen

IPC分类号： C12N15/85 ,  C12N5/06 ,  A01K67/027 ,  A61K49/00 ,  A61K38/00

CPC分类号： C12N15/8509 ,  A01K2217/075 ,  A01K2267/0306 ,  A01K2267/0362 ,  A01K2267/0375

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

公开(公告)号：EP1863340A2

公开(公告)日：2007-12-12

申请号：EP06736637.7

申请日：2006-02-27

申请人： Genentech, Inc. ,  Lexicon Pharmaceuticals, Inc.

发明人： HORNER, Allison Anne Byers ,  CLARKE, Catherine Anne B. ,  COMBS, Katherin E. ,  DESAUVAGE, Frederic ,  EDWARDS, Joel ,  GODOWSKI, Paul ,  GRANT, Deanna ,  HUANG, Wenhu ,  KETCHERSIDE, Lorelei Diane ,  MASSEY, Erin Marie ,  MONTGOMERY, Charles A. ,  PAYNE, Bobby Joe ,  PETERSON, Andrew ,  QIAN, Ni Nancy ,  SCHRICK, Jeffrey L. ,  SHI, Zheng-Zheng ,  SPARKS, Mary Jean ,  STALA, Joy ,  VIATOR, Colleen M. ,  VOGEL, Peter ,  YE, Weilan ,  YEH, Jung-Hua ,  DING, Zhiyong

IPC分类号： A01K67/027 ,  C07K14/47 ,  C07K14/515 ,  C07K16/18 ,  G01N33/50 ,  C12N5/10 ,  A61K39/395

CPC分类号： C07K14/47 ,  A01K2217/075 ,  A61K2039/505 ,  G01N2500/00

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO179, PRO181, PRO244, PRO247, PRO269, PRO293, PRO298, PRO339, PRO341, PRO347, PRO531, PRO537, PRO718, PRO773, PRO860, PRO871, PRO872, PRO813, PRO828, PRO1100, PRO1114, PRO1115, PRO1126, PRO1133, PRO1154, PRO1185, PRO1194, PRO1287, PRO1291, PRO1293, PRO1310, PRO1312, PRO1335, PRO1339, PRO2155, PRO1356, PRO1385, PRO1412, PRO1487, PRO1758, PRO1779, PRO1785, PRO1889, PRO90318, PRO3434, PRO3579, PRO4322, PRO4343, PRO4347, PRO4403, PRO4976, PRO260, PRO6014, PRO6027, PRO6181, PRO6714, PRO9922, PRO7179, PRO7476, PRO9824, PRO19814, PRO19836, PRO20088, PRO70789, PRO50298, PRO51592, PRO1757, PRO4421, PRO9903, PRO1106, PRO1411, PRO1486, PRO1565, PRO4399 or PRO4404 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

公开(公告)号：EP1871163A2

公开(公告)日：2008-01-02

申请号：EP06770779.4

申请日：2006-05-18

申请人： Genentech, Inc. ,  Lexicon Pharmaceuticals, Inc.

发明人： COMBS, Katherin ,  CULBERTSON, Ling Ling ,  DESAUVAGE, Frederic ,  DING, Zhiyong ,  EDWARDS, Joel ,  GIRGIS, Rosemary ,  JUNGE, Harald ,  JUNUTULA, Jagath Reddy ,  MASSEY, Erin Marie ,  MCLAIN, Dina Rebecca ,  MONTGOMERY, Charles A. ,  PAYNE, Bobby Joe ,  PHILLIPS, Heidi ,  QIAN, Ni Nancy ,  RANGEL, Carolina ,  SHI, Zheng-Zheng ,  SPARKS, Mary Jean ,  STALA, Joy ,  VOGEL, Peter ,  SEVAUX, Tracy, Ellen, Willis ,  YE, Weilan ,  HORNER, Allison, Ann, Byers

IPC分类号： A01K67/027 ,  C12N15/85 ,  G01N33/00

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  C12N15/8509

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, PRO265, PRO309, PRO332, PRO342, PRO356, PRO540, PRO618, PRO944, PRO994, PRO1079, PRO1110, PRO1122, PRO1138, PRO1190, PRO1272, PRO1286, PRO1295, PRO1309, PRO1316, PRO1383, PRO1384, PRO1431, PRO1434, PRO1475, PRO1481, PRO1568, PRO1573, PRO1599, PRO1604, PRO1605, PRO1693, PRO1753, PRO1755, PRO1777, PRO1788, PRO1864, PRO1925, PRO1926, PRO3566, PRO4330, PRO4423, PRO36935, PRO4977, PRO4979, PRO4980, PRO4981, PRO5801, PRO5995, PRO6001, PRO6095, PRO6182, PRO7170, PRO7171, PRO7436, PRO9912, PRO9917, PRO37337, PRO37496, PRO19646, PRO21718, PRO19820, PRO21201, PRO20026, PRO20110, PRO23203 or PRO35250 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

公开(公告)号：EP1817335A2

公开(公告)日：2007-08-15

申请号：EP05837234.3

申请日：2005-10-18

申请人： GENENTECH, INC. ,  Lexicon Pharmaceuticals, Inc.

发明人： BYERS-HORNER, Allison Anne ,  COMBS, Katherin ,  DESAUVAGE, Frederic ,  DING, Zhiyong ,  FRENCH, Dorothy ,  GONZALEZ, Lino ,  MASSEY, Erin Marie ,  MINZE, Laurie Jeanette ,  MONTGOMERY, Charles A. ,  PRAETOR, Asja ,  RANGEL, Carolina ,  SHI, Zheng-zheng ,  SPARKS, Mary Jean ,  STALA, Joy ,  VOGEL, Peter ,  WILLIS-SEVAUX, Tracy Ellen ,  YE, Weilan

IPC分类号： C07K14/47

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/035

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO194, PRO220, PRO241, PRO284, PRO331, PRO354, PRO355, PRO533, PRO541, PRO725, PRO937, PRO1014, PRO1120, PRO1182, PRO1325, PRO1382, PRO1410, PRO1555, PRO1556, PRO1760, PRO1787, PRO1868, PRO4326, PRO4332, PRO4346, PRO4400, PRO6003, PRO6094, PRO6244, PRO9820, PRO9828, PRO10274, PRO16090, PRO19644, PRO21340, PRO92165, PRO85143, PRO1124, PRO1026 or PRO23370 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

公开(公告)号：EP2010662A2

公开(公告)日：2009-01-07

申请号：EP07863338.5

申请日：2007-04-18

申请人： Genentech, Inc. ,  Lexicon Pharmaceuticals, Inc.

发明人： BOLLINGER, Kristi Rae ,  DESAUVAGE, Frederic ,  EDWARDS, Joel A. ,  GIRGIS, Rosemary ,  GREEN, Leslie ,  MINZE, Laurie Jeanette ,  PAYNE, Bobby Joe ,  RANGEL, Carolina ,  SHI, Zheng-zheng ,  SPARKS, Mary Jean ,  TANG, Tracy Tzu-ling ,  VOGEL, Peter

IPC分类号： C12N15/85 ,  C12N5/00 ,  C07K16/00 ,  G01N33/50 ,  A61K39/395

CPC分类号： C12Q1/6883 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0375 ,  C07K14/705 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO286, PRO706, PRO1800, PRO4354, PRO6029, PRO9739, PRO20044, PRO28631 or PRO34128 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.