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公开(公告)号：EP1660884B1
公开(公告)日：2012-05-23
申请号：EP03770230.5
申请日：2003-08-04
发明人： GEE, Kyle , MARTIN, Vladimir
IPC分类号： C07D273/00 , C07H21/00 , C09B57/10 , C09B69/00 , G01N33/58 , G01N33/84 , G01N33/53 , A61K49/00
CPC分类号： C07D273/01 , C07D413/04 , C09B57/10 , C09B69/00 , G01N33/84
摘要： The invention describes crown ether chelators, including crown ethers having the formula (A) or (B); and aza-substituted and thia-substituted analogs thereof. These crown ethers may be substituted by a dye moiety, a chemically reactive group, a conjugated substance, or a combination thereof. Chelators that are substituted by fluorescent dyes are particularly useful as indicators for metal cations, particularly Na+ and K+ ions, and particularly where binding of the target ion results in a change in the fluorescence properties of the indicator that can be correlated with the ion concentration. Methods are provided for utilizing reactive groups on the chelators for conjugation to dyes, lipids and polymers and methods for enhancing entry of the indicators into living cells.
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公开(公告)号：EP2379515B1
公开(公告)日：2014-02-12
申请号：EP09837113.1
申请日：2009-12-29
发明人： GEE, Kyle , MARTIN, Vladimir
IPC分类号： C07D263/56 , G01N33/58 , G01N33/84 , C07D401/04 , C07D413/04 , C07D417/04 , C07D471/06 , C07D491/16 , C07D263/57 , C07F3/04 , C09K11/06 , G01N33/52
CPC分类号： G01N21/75 , C07D263/56 , C07D263/57 , C07D401/04 , C07D413/04 , C07D417/04 , C07D471/06 , C07D491/16 , C09B57/00 , C09B57/02 , C09K11/06 , C09K2211/1007 , C09K2211/1014 , C09K2211/1029 , C09K2211/1033 , C09K2211/1037 , C09K2211/1048 , C09K2211/1088 , G01N33/582 , G01N33/84
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公开(公告)号：EP2064290B1
公开(公告)日：2013-10-09
申请号：EP07871255.1
申请日：2007-10-26
CPC分类号： G01N33/84 , C07D209/14 , C07D311/82 , C07D311/90 , C07D405/12 , C07D413/04 , C07D491/22 , C07F5/02 , C07K1/13 , C09B7/00 , C09B11/12 , C09B11/24 , C09B11/28 , C09B57/00 , C09B69/00 , C09K11/06 , G01N31/22 , G01N33/5005 , G01N33/5058 , G01N33/5091 , G01N33/582 , G01N33/80 , G01N2333/245 , Y10T436/143333
摘要： A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula (I), wherein the variables are described throughout the application.
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4.发明公开
公开(公告)号：EP2379515A2
公开(公告)日：2011-10-26
申请号：EP09837113.1
申请日：2009-12-29
发明人： GEE, Kyle , MARTIN, Vladimir
IPC分类号： C07D263/58 , C07D263/56
CPC分类号： G01N21/75 , C07D263/56 , C07D263/57 , C07D401/04 , C07D413/04 , C07D417/04 , C07D471/06 , C07D491/16 , C09B57/00 , C09B57/02 , C09K11/06 , C09K2211/1007 , C09K2211/1014 , C09K2211/1029 , C09K2211/1033 , C09K2211/1037 , C09K2211/1048 , C09K2211/1088 , G01N33/582 , G01N33/84
摘要： Disclosed are benzoxazole-based compounds, kits, and methods of producing and using the described compounds in fluorescence-based detection of analytes (e.g., metal ions). Also disclosed are uses of benzoxazole-based compounds as ratiometric metal ion indicators.
摘要翻译： 公开了基于苯并恶唑的化合物，试剂盒以及在分析物（例如金属离子）的基于荧光的检测中制备和使用所述化合物的方法。 还公开了苯并恶唑类化合物作为比例金属离子指示剂的用途。
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公开(公告)号：EP2064290A2
公开(公告)日：2009-06-03
申请号：EP07871255.1
申请日：2007-10-26
CPC分类号： G01N33/84 , C07D209/14 , C07D311/82 , C07D311/90 , C07D405/12 , C07D413/04 , C07D491/22 , C07F5/02 , C07K1/13 , C09B7/00 , C09B11/12 , C09B11/24 , C09B11/28 , C09B57/00 , C09B69/00 , C09K11/06 , G01N31/22 , G01N33/5005 , G01N33/5058 , G01N33/5091 , G01N33/582 , G01N33/80 , G01N2333/245 , Y10T436/143333
摘要： A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula (I), wherein the variables are described throughout the application.
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