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公开(公告)号：EP2780853B1
公开(公告)日：2019-05-01
申请号：EP12798036.5
申请日：2012-09-28
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公开(公告)号：EP4044188A1
公开(公告)日：2022-08-17
申请号：EP22152064.6
申请日：2013-09-13
发明人： MAJUMDAR, Nivedita, Sumi , WESSEL, Thomas , WOO, David C. , SIKORA, Marcin , JANAWAY, Gordon , RAIZADA, Shweta , LANKESTER, Joanna , MARKS, Jeffrey , WESSEL, Daniel
摘要： A computer-implemented method for designing a digital PCR (dPCR) experiment is provided. The method includes receiving, from a user, a selection of optimization type. The optimization type may be maximizing the dynamic range, minimizing the number of substrates including reaction sites needed for the experiment, determining a dilution factor, or determining the lower limit of detection, for example. The method further includes receiving, from the user, a precision measure for an experiment, and a minimum concentration of a target in a reaction site for the experiment. The method also includes determining a set of dPCR experiment design factors for the experiment based on the optimization type. The set of dPCR experiment design factors is then displayed to the user.
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公开(公告)号：EP2761585B1
公开(公告)日：2019-08-07
申请号：EP12784376.1
申请日：2012-09-30
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公开(公告)号：EP3253492A2
公开(公告)日：2017-12-13
申请号：EP16708007.6
申请日：2016-02-05
发明人： CHU, Yong , MARKS, Jeffrey , FREUDENTHAL, Jacob , CHEN, Mingsong , TOH, Tiong Han , AGUANNO, Mauro , LAU, Lik Seng , LOH, Lian Seng , TEO, Kok Siong , CHU, Zeng Wei , MATHERS, Xin , UY, Michael , YEO, Huei Steven , BOO, Kuan Moon , LEE, Way Xuang , KOO, Chin Yong , TEO, Wei Fuh , LAU, Soo Yong , SHIN, Hon Siu , TAN, Zeqi , WESSEL, Thomas , WOO, David
CPC分类号： B01L7/52 , B01L2200/145 , B01L2300/18 , B01L2300/1822 , C12Q1/6806 , G01N21/274 , G01N21/6452 , G01N21/6486 , G01N35/026 , G01N2021/6439 , G01N2035/00316 , G01N2035/00366 , G01N2201/061 , G01N2201/12
摘要： A biological analysis system is provided. The system comprises a sample block assembly. The sample block assembly comprises a sample block configured to accommodate a sample holder, the sample holder configured to receive a plurality of samples. The system also comprises a control system configured to cycle the plurality of samples through a series of temperatures. The system further comprises an automated tray comprising a slide assembly, the tray configured to reversibly slide the sample block assembly from a closed to an open position to allow user access to the plurality of sample holders.
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公开(公告)号：EP4379392A2
公开(公告)日：2024-06-05
申请号：EP24157142.1
申请日：2016-02-05
发明人： CHU, Yong , MARKS, Jeffrey , FREUDENTHAL, Jacob , CHEN, Mingsong , TOH, Tiong Han , AGUANNO, Mauro , LAU, Lik Seng , LOH, Lian Seng , TEO, Kok Siong , CHU, Zeng Wei , MATHERS, Xin , UY, Michael , YEO, Huei Steven , BOO, Kuan Moon , LEE, Way Xuang , KOO, Chin Yong , TEO, Wei Fuh , LAU, Soo Yong , SHIN, Hon Siu , TAN, Zeqi , WESSEL, Thomas , WOO, David
IPC分类号： G01N35/00
CPC分类号： G01N35/026 , G01N2035/0031620130101 , G01N2035/0036620130101 , G01N21/274 , G01N21/6452 , G01N2021/643920130101 , B01L2200/14520130101 , B01L2300/182220130101 , B01L7/52
摘要： A biological analysis system is provided. The system comprises a sample block assembly. The sample block assembly comprises a sample block configured to accommodate a sample holder, the sample holder configured to receive a plurality of samples. The system also comprises a control system configured to cycle the plurality of samples through a series of temperatures. The system further comprises an automated tray comprising a slide assembly, the tray configured to reversibly slide the sample block assembly from a closed to an open position to allow user access to the plurality of sample holders.
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6.发明公开METHODS AND SYSTEMS FOR KNOWLEDGE DISCOVERY USING BIOLOGICAL DATA 审中-公开VERFAHREN UND SYSTEME ZUR WISSENSENTDECKUNG ANHAND VON BIOLOGISCHEN DATEN
公开(公告)号：EP3123382A1
公开(公告)日：2017-02-01
申请号：EP15718011.8
申请日：2015-03-24
发明人： MAJUMDAR, Nivedita Sumi , LEONG, Harrison , POTHINI, Shakila , HOARD, David , FONG, Christopher , SOARES, Pratik Simon , KUMAR, Salil , WESSEL, Thomas , ALIMINATI, Manjula , EGRY, Levente
CPC分类号： G06F19/28 , G06F17/30864 , G06F19/22 , G06F19/26
摘要： A system for analyzing biological data, comprising: a storage configured to store a plurality of data files containing biological data obtained from a plurality of devices; a server configured to: host a plurality of applications, each configured to be implemented on the server and to provide analysis, manipulation, comparison, visualization, or a combination thereof, of the biological data included in the data files, wherein the plurality of applications allow a user to analyze different data files related to the same sample and compare the results of the analysis.
摘要翻译： 一种用于分析生物数据的系统，包括：存储器，被配置为存储包含从多个装置获得的生物数据的多个数据文件; 服务器，被配置为：主持多个应用，每个应用被配置为在服务器上实现并且提供包括在数据文件中的生物数据的分析，操作，比较，可视化或其组合，其中所述多个应用 允许用户分析与同一样本相关的不同数据文件，并比较分析结果。
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公开(公告)号：EP4354445A1
公开(公告)日：2024-04-17
申请号：EP23212037.8
申请日：2015-03-24
发明人： MAJUMDAR, Nivedita Sumi , LEONG, Harrison , POTHINI, Shakila , HOARD, David , FONG, Christopher , SOARES, Pratik Simon , KUMAR, Salil , WESSEL, Thomas , ALIMINATI, Manjula , EGRY, Levente
摘要： A system for analyzing biological data, comprising: a storage configured to store a plurality of data files containing biological data obtained from a plurality of devices; a server configured to: host a plurality of applications, each configured to be implemented on the server and to provide analysis, manipulation, comparison, visualization, or a combination thereof, of the biological data included in the data files, wherein the plurality of applications allow a user to analyze different data files related to the same sample and compare the results of the analysis.
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公开(公告)号：EP3254079A2
公开(公告)日：2017-12-13
申请号：EP16705012.9
申请日：2016-02-05
发明人： CHU, Yong , MARKS, Jeffrey , FREUDENTHAL, Jacob , WESSEL, Thomas , WOO, David
CPC分类号： G01N21/6428 , C12Q1/6851 , C12Q1/686 , G01N21/274 , G01N21/278 , G01N21/6452 , G01N21/6456 , G01N2021/6439 , G01N2021/6471 , G01N2201/127 , G01N2201/13 , G01N2333/922
摘要： In one exemplary embodiment, a method for calibrating an instrument is provided. The instrument includes an optical system capable of imaging florescence emission from a plurality of reaction sites. The method includes performing a region-of-interest (ROI) calibration to determine reaction site positions in an image. The method further includes performing a pure dye calibration to determine the contribution of a fluorescent dye used in each reaction site by comparing a raw spectrum of the fluorescent dye to a pure spectrum calibration data of the fluorescent dye. The method further includes performing an instrument normalization calibration to determine a filter normalization factor. The method includes performing an RNase P validation to validate the instrument is capable of distinguishing between two different quantities of sample.
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9.发明公开METHODS AND SYSTEMS FOR BACKGROUND SUBTRACTION IN AN IMAGE 审中-公开VERFAHREN UND SYSTEME ZUR HINTERGRUNDSUBSTRAKTION IN EINEM BILD
公开(公告)号：EP2761593A1
公开(公告)日：2014-08-06
申请号：EP12781205.5
申请日：2012-09-28
发明人： CHENG, Francis T. , WESSEL, Thomas
CPC分类号： G06T7/0012 , G06T5/50 , G06T7/70 , G06T2207/20068 , G06T2207/30024 , G06T2207/30072
摘要： A method for improving image quality is provided. The method includes receiving image data of a substrate, wherein the image data is generated by imaging the substrate, and an image is generated from the image data. The method further includes generating a background representation from a background noise portion of the image, wherein the background portion includes signal information undesired for further processing and generating a background subtracted image by subtracting the background representation from the image. In this way, a separate background image is not needed to subtract the background from the image including the regions-of-interest to improve image quality.
摘要翻译： 提供了一种提高图像质量的方法。 该方法包括接收衬底的图像数据，其中通过对衬底进行成像而生成图像数据，并且从图像数据生成图像。 该方法还包括从图像的背景噪声部分生成背景表示，其中背景部分包括不期望用于进一步处理的信号信息，并且通过从图像中减去背景重现来生成背景相减图像。 以这种方式，不需要单独的背景图像从包括感兴趣区域的图像中减去背景以提高图像质量。
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公开(公告)号：EP4379392A3
公开(公告)日：2024-08-21
申请号：EP24157142.1
申请日：2016-02-05
发明人： CHU, Yong , MARKS, Jeffrey , FREUDENTHAL, Jacob , CHEN, Mingsong , TOH, Tiong Han , AGUANNO, Mauro , LAU, Lik Seng , LOH, Lian Seng , TEO, Kok Siong , CHU, Zeng Wei , MATHERS, Xin , UY, Michael , YEO, Huei Steven , BOO, Kuan Moon , LEE, Way Xuang , KOO, Chin Yong , TEO, Wei Fuh , LAU, Soo Yong , SHIN, Hon Siu , TAN, Zeqi , WESSEL, Thomas , WOO, David
CPC分类号： G01N35/026 , G01N2035/0031620130101 , G01N2035/0036620130101 , G01N21/274 , G01N21/6452 , G01N2021/643920130101 , B01L2200/14520130101 , B01L2300/182220130101 , B01L7/52
摘要： A biological analysis system is provided. The system comprises a sample block assembly. The sample block assembly comprises a sample block configured to accommodate a sample holder, the sample holder configured to receive a plurality of samples. The system also comprises a control system configured to cycle the plurality of samples through a series of temperatures. The system further comprises an automated tray comprising a slide assembly, the tray configured to reversibly slide the sample block assembly from a closed to an open position to allow user access to the plurality of sample holders.
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