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公开(公告)号：EP3253492A2
公开(公告)日：2017-12-13
申请号：EP16708007.6
申请日：2016-02-05
发明人： CHU, Yong , MARKS, Jeffrey , FREUDENTHAL, Jacob , CHEN, Mingsong , TOH, Tiong Han , AGUANNO, Mauro , LAU, Lik Seng , LOH, Lian Seng , TEO, Kok Siong , CHU, Zeng Wei , MATHERS, Xin , UY, Michael , YEO, Huei Steven , BOO, Kuan Moon , LEE, Way Xuang , KOO, Chin Yong , TEO, Wei Fuh , LAU, Soo Yong , SHIN, Hon Siu , TAN, Zeqi , WESSEL, Thomas , WOO, David
CPC分类号： B01L7/52 , B01L2200/145 , B01L2300/18 , B01L2300/1822 , C12Q1/6806 , G01N21/274 , G01N21/6452 , G01N21/6486 , G01N35/026 , G01N2021/6439 , G01N2035/00316 , G01N2035/00366 , G01N2201/061 , G01N2201/12
摘要： A biological analysis system is provided. The system comprises a sample block assembly. The sample block assembly comprises a sample block configured to accommodate a sample holder, the sample holder configured to receive a plurality of samples. The system also comprises a control system configured to cycle the plurality of samples through a series of temperatures. The system further comprises an automated tray comprising a slide assembly, the tray configured to reversibly slide the sample block assembly from a closed to an open position to allow user access to the plurality of sample holders.
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公开(公告)号：EP4379392A2
公开(公告)日：2024-06-05
申请号：EP24157142.1
申请日：2016-02-05
发明人： CHU, Yong , MARKS, Jeffrey , FREUDENTHAL, Jacob , CHEN, Mingsong , TOH, Tiong Han , AGUANNO, Mauro , LAU, Lik Seng , LOH, Lian Seng , TEO, Kok Siong , CHU, Zeng Wei , MATHERS, Xin , UY, Michael , YEO, Huei Steven , BOO, Kuan Moon , LEE, Way Xuang , KOO, Chin Yong , TEO, Wei Fuh , LAU, Soo Yong , SHIN, Hon Siu , TAN, Zeqi , WESSEL, Thomas , WOO, David
IPC分类号： G01N35/00
CPC分类号： G01N35/026 , G01N2035/0031620130101 , G01N2035/0036620130101 , G01N21/274 , G01N21/6452 , G01N2021/643920130101 , B01L2200/14520130101 , B01L2300/182220130101 , B01L7/52
摘要： A biological analysis system is provided. The system comprises a sample block assembly. The sample block assembly comprises a sample block configured to accommodate a sample holder, the sample holder configured to receive a plurality of samples. The system also comprises a control system configured to cycle the plurality of samples through a series of temperatures. The system further comprises an automated tray comprising a slide assembly, the tray configured to reversibly slide the sample block assembly from a closed to an open position to allow user access to the plurality of sample holders.
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公开(公告)号：EP2959284A2
公开(公告)日：2015-12-30
申请号：EP14709128.4
申请日：2014-02-24
发明人： CHEN, Mingsong , AGUANNO, Mauro , BOO, Kuan Moon , SOH, Woon Liang Terence , FREUDENTHAL, Jacob , MARKS, Jeffrey
IPC分类号： G01N21/27
CPC分类号： G01N21/6486 , G01N21/0332 , G01N21/274 , G01N21/645 , G01N21/6452 , G01N2201/061 , G01N2201/0624 , G01N2201/0627 , G01N2201/121
摘要： An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.
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公开(公告)号：EP4185858A2
公开(公告)日：2023-05-31
申请号：EP21755281.9
申请日：2021-07-23
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公开(公告)号：EP4185857A2
公开(公告)日：2023-05-31
申请号：EP21755280.1
申请日：2021-07-23
发明人： FREUDENTHAL, Jacob , BENSON, Scott
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公开(公告)号：EP4379392A3
公开(公告)日：2024-08-21
申请号：EP24157142.1
申请日：2016-02-05
发明人： CHU, Yong , MARKS, Jeffrey , FREUDENTHAL, Jacob , CHEN, Mingsong , TOH, Tiong Han , AGUANNO, Mauro , LAU, Lik Seng , LOH, Lian Seng , TEO, Kok Siong , CHU, Zeng Wei , MATHERS, Xin , UY, Michael , YEO, Huei Steven , BOO, Kuan Moon , LEE, Way Xuang , KOO, Chin Yong , TEO, Wei Fuh , LAU, Soo Yong , SHIN, Hon Siu , TAN, Zeqi , WESSEL, Thomas , WOO, David
CPC分类号： G01N35/026 , G01N2035/0031620130101 , G01N2035/0036620130101 , G01N21/274 , G01N21/6452 , G01N2021/643920130101 , B01L2200/14520130101 , B01L2300/182220130101 , B01L7/52
摘要： A biological analysis system is provided. The system comprises a sample block assembly. The sample block assembly comprises a sample block configured to accommodate a sample holder, the sample holder configured to receive a plurality of samples. The system also comprises a control system configured to cycle the plurality of samples through a series of temperatures. The system further comprises an automated tray comprising a slide assembly, the tray configured to reversibly slide the sample block assembly from a closed to an open position to allow user access to the plurality of sample holders.
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公开(公告)号：EP3254080A1
公开(公告)日：2017-12-13
申请号：EP16706289.2
申请日：2016-02-05
发明人： WESSEL, Thomas , CHU, Yong , FREUDENTHAL, Jacob , WOO, David
CPC分类号： G01N21/6428 , G01N21/274 , G01N21/6452 , G01N21/6456 , G01N2021/6439 , G06F19/24
摘要： In one exemplary embodiment, a method for validating an instrument is provided. The method includes receiving amplification data from a validation plate to generate a plurality of amplification curves. The validation plate includes a sample of a first quantity and a second quantity, and each amplification curve includes an exponential region. The method further includes determining a set of fluorescence thresholds based on the exponential regions of the plurality of amplification curves and determining, for each fluorescence threshold of the set, a first set of cycle threshold (Ct) values of amplification curves generated from the samples of the first quantity and a second set of Ct values of amplification curves generated from the samples of the second quantity. The method includes calculating if the first and second quantities are sufficiently distinguishable based on Ct values at each of the plurality of fluorescence thresholds.
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公开(公告)号：EP2760583A2
公开(公告)日：2014-08-06
申请号：EP12787175.4
申请日：2012-09-28
发明人： DANEHY, Ronald , LIM, Gary , FREUDENTHAL, Jacob
摘要： A case for containing a plurality of biological samples contains a base, a substrate and a cover. The substrate is attached to the base and comprises a plurality of reaction regions configured to receive one or more biological samples. The cover comprises an inner surface and is configured to be attached to the base such that the base and cover together provide a cavity containing the substrate. The inner surface includes a central area and a recessed area disposed about the central area. The central area is configured to cover the reaction regions, while the recessed area is offset from the central area in a direction normal to the inner surface.
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公开(公告)号：EP2760583B1
公开(公告)日：2020-05-06
申请号：EP12787175.4
申请日：2012-09-28
发明人： DANEHY, Ronald , LIM, Gary , FREUDENTHAL, Jacob
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公开(公告)号：EP3254083A1
公开(公告)日：2017-12-13
申请号：EP16708006.8
申请日：2016-02-05
发明人： CHU, Yong , FREUDENTHAL, Jacob , MARKS, Jeffrey
CPC分类号： C12Q1/686 , G01N21/274 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N2021/6421 , G01N2021/6441 , G01N2201/127
摘要： Some embodiments describe a computer-implemented method for calibrating a fluorescent dye. The method can comprise imaging a sample holder, loaded into an instrument, at more than one channel. The sample holder can comprise a plurality of reaction sites and more than one dye type, with each dye occupying more than one reaction site. The method can further comprise identifying a peak channel for each dye on the sample holder, normalizing each channel to the peak channel for each dye, and producing a dye matrix that can comprise a set of dye reference values.
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