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公开(公告)号：EP4453553A1
公开(公告)日：2024-10-30
申请号：EP22854245.2
申请日：2022-12-20
发明人： LIM, Beng Heng , LOH, Wuh Ken , KUAH, Hwee Siong , WONG, Jing Han , GANGCUANGCO, Jefferson Cruz , ONG, Jin Xin , LAU, Soo Yong , XU, Yanping , SHAPIRO, Victor , TEH, Zhi Da , CHONG, Chee Woei , BOO, Kuan Moon
IPC分类号： G01N27/447
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公开(公告)号：EP3107658B1
公开(公告)日：2018-07-04
申请号：EP15704906.5
申请日：2015-02-04
发明人： LIM, Chee Kiong , LEE, Way Xuang , LOH, Wuh Ken , CHING, Chee Wee , KOO, Chin Yong , KOH, Siew Ying , TOH, Tiong Han , BOO, Kuan Moon , LAU, Soo Yong
IPC分类号： B01L7/00
CPC分类号： B01L7/52 , B01L2200/147 , B01L2300/0829 , B01L2300/1805 , B01L2300/1822 , B01L2300/1883 , C12Q1/6806
摘要： In one aspect, a thermal cycler system including a sample block and a thermoelectric device is disclosed. In various embodiments, the sample block has a first surface configured to receive a plurality of reaction vessels and an opposing second surface. In various embodiments the thermoelectric device is operably coupled to the second surface of the sample block. In various embodiments a thermal control unit is provided. In various embodiments the thermal control unit includes a computer processing unit. In various embodiments the thermal control unit includes an electrical current source. In various embodiments the thermal control unit also includes an electrical interface portion configured to connect the thermoelectric device with the electrical current source by way of an electrical cable. In various embodiments the thermal control unit is oriented in a different plane than the sample block and thermoelectric cooler.
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公开(公告)号：EP3253492A2
公开(公告)日：2017-12-13
申请号：EP16708007.6
申请日：2016-02-05
发明人： CHU, Yong , MARKS, Jeffrey , FREUDENTHAL, Jacob , CHEN, Mingsong , TOH, Tiong Han , AGUANNO, Mauro , LAU, Lik Seng , LOH, Lian Seng , TEO, Kok Siong , CHU, Zeng Wei , MATHERS, Xin , UY, Michael , YEO, Huei Steven , BOO, Kuan Moon , LEE, Way Xuang , KOO, Chin Yong , TEO, Wei Fuh , LAU, Soo Yong , SHIN, Hon Siu , TAN, Zeqi , WESSEL, Thomas , WOO, David
CPC分类号： B01L7/52 , B01L2200/145 , B01L2300/18 , B01L2300/1822 , C12Q1/6806 , G01N21/274 , G01N21/6452 , G01N21/6486 , G01N35/026 , G01N2021/6439 , G01N2035/00316 , G01N2035/00366 , G01N2201/061 , G01N2201/12
摘要： A biological analysis system is provided. The system comprises a sample block assembly. The sample block assembly comprises a sample block configured to accommodate a sample holder, the sample holder configured to receive a plurality of samples. The system also comprises a control system configured to cycle the plurality of samples through a series of temperatures. The system further comprises an automated tray comprising a slide assembly, the tray configured to reversibly slide the sample block assembly from a closed to an open position to allow user access to the plurality of sample holders.
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4.发明公开APPARATUSES, SYSTEMS AND METHODS FOR PROVIDING SCALABLE THERMAL CYCLERS AND ISOLATING THERMOELECTRIC DEVICES 有权设备，系统和提供可扩展的热循环器和隔离热电装置的方法
公开(公告)号：EP3107658A1
公开(公告)日：2016-12-28
申请号：EP15704906.5
申请日：2015-02-04
发明人： LIM, Chee Kiong , LEE, Way Xuang , LOH, Wuh Ken , CHING, Chee Wee , KOO, Chin Yong , KOH, Siew Ying , TOH, Tiong Han , BOO, Kuan Moon , LAU, Soo Yong
IPC分类号： B01L7/00
CPC分类号： B01L7/52 , B01L2200/147 , B01L2300/0829 , B01L2300/1805 , B01L2300/1822 , B01L2300/1883 , C12Q1/6806
摘要： In one aspect, a thermal cycler system including a sample block and a thermoelectric device is disclosed. In various embodiments, the sample block has a first surface configured to receive a plurality of reaction vessels and an opposing second surface. In various embodiments the thermoelectric device is operably coupled to the second surface of the sample block. In various embodiments a thermal control unit is provided. In various embodiments the thermal control unit includes a computer processing unit. In various embodiments the thermal control unit includes an electrical current source. In various embodiments the thermal control unit also includes an electrical interface portion configured to connect the thermoelectric device with the electrical current source by way of an electrical cable. In various embodiments the thermal control unit is oriented in a different plane than the sample block and thermoelectric cooler.
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公开(公告)号：EP4379392A3
公开(公告)日：2024-08-21
申请号：EP24157142.1
申请日：2016-02-05
发明人： CHU, Yong , MARKS, Jeffrey , FREUDENTHAL, Jacob , CHEN, Mingsong , TOH, Tiong Han , AGUANNO, Mauro , LAU, Lik Seng , LOH, Lian Seng , TEO, Kok Siong , CHU, Zeng Wei , MATHERS, Xin , UY, Michael , YEO, Huei Steven , BOO, Kuan Moon , LEE, Way Xuang , KOO, Chin Yong , TEO, Wei Fuh , LAU, Soo Yong , SHIN, Hon Siu , TAN, Zeqi , WESSEL, Thomas , WOO, David
CPC分类号： G01N35/026 , G01N2035/0031620130101 , G01N2035/0036620130101 , G01N21/274 , G01N21/6452 , G01N2021/643920130101 , B01L2200/14520130101 , B01L2300/182220130101 , B01L7/52
摘要： A biological analysis system is provided. The system comprises a sample block assembly. The sample block assembly comprises a sample block configured to accommodate a sample holder, the sample holder configured to receive a plurality of samples. The system also comprises a control system configured to cycle the plurality of samples through a series of temperatures. The system further comprises an automated tray comprising a slide assembly, the tray configured to reversibly slide the sample block assembly from a closed to an open position to allow user access to the plurality of sample holders.
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公开(公告)号：EP3917673A1
公开(公告)日：2021-12-08
申请号：EP20708918.6
申请日：2020-01-30
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7.发明公开
公开(公告)号：EP2760585A2
公开(公告)日：2014-08-06
申请号：EP12784373.8
申请日：2012-09-28
发明人： FREUDENTHAL, Jacob K. , DAHLHOFF, Geoffrey , MAHER, Kevin , CHEN, Mingsong , LIM, Gary , DANEHY, Ronald , FORTESCUE, David , SHEN, Ming , SOH, Woon Liang Terence , CHENG, Francis , WU, Ruoyun , LEE, Thiam Chye , CHAPPELL, Gary , LIM, Chee Kiong , DERE, Jeff , STRAUB, Ted , FONSECA, Jorge , BOO, Kuan Moon , LAU, Soo Yong
CPC分类号： C12Q1/686 , B01L3/50855 , B01L3/50857 , B01L7/52 , B01L2200/023 , B01L2200/025 , B01L2200/028 , B01L2200/143 , B01L2300/021 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , B01L2300/1827 , B01L2300/1844
摘要： A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.
摘要翻译： 提供生物分析系统。 该系统包括被配置为容纳多个样本保持器中的任何一个的可互换组件，每个样本保持器被配置为接收多个样本。 该系统还包括配置成使多个样品循环通过一系列温度的控制系统。 该系统还包括被配置为检测从多个样本发射的荧光信号的光学系统。 特别地，光学系统可以包括单个场透镜，激发源，光学传感器和多个滤光器组件。 激发源可以是一个或多个发光二极管。 场透镜可以是双凸透镜。
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公开(公告)号：EP4379392A2
公开(公告)日：2024-06-05
申请号：EP24157142.1
申请日：2016-02-05
发明人： CHU, Yong , MARKS, Jeffrey , FREUDENTHAL, Jacob , CHEN, Mingsong , TOH, Tiong Han , AGUANNO, Mauro , LAU, Lik Seng , LOH, Lian Seng , TEO, Kok Siong , CHU, Zeng Wei , MATHERS, Xin , UY, Michael , YEO, Huei Steven , BOO, Kuan Moon , LEE, Way Xuang , KOO, Chin Yong , TEO, Wei Fuh , LAU, Soo Yong , SHIN, Hon Siu , TAN, Zeqi , WESSEL, Thomas , WOO, David
IPC分类号： G01N35/00
CPC分类号： G01N35/026 , G01N2035/0031620130101 , G01N2035/0036620130101 , G01N21/274 , G01N21/6452 , G01N2021/643920130101 , B01L2200/14520130101 , B01L2300/182220130101 , B01L7/52
摘要： A biological analysis system is provided. The system comprises a sample block assembly. The sample block assembly comprises a sample block configured to accommodate a sample holder, the sample holder configured to receive a plurality of samples. The system also comprises a control system configured to cycle the plurality of samples through a series of temperatures. The system further comprises an automated tray comprising a slide assembly, the tray configured to reversibly slide the sample block assembly from a closed to an open position to allow user access to the plurality of sample holders.
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公开(公告)号：EP3254085A1
公开(公告)日：2017-12-13
申请号：EP16705683.7
申请日：2016-02-05
发明人： CHEN, Mingsong , BOO, Kuan Moon , TOH, Tiong Han , AGUANNO, Mauro , LAU, Soo Yong , YEO, Huei Steven , TEO, Wei Fuh
CPC分类号： C12Q1/686 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0829 , B01L2300/168 , B01L2300/18 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/6458 , G01N2021/6463 , G02B21/244
摘要： An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The may instrument further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument.
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公开(公告)号：EP2648847A2
公开(公告)日：2013-10-16
申请号：EP11806035.9
申请日：2011-12-08
发明人： YEO, Huei , LAU, Soo Yong , CONG, Jiang
IPC分类号： B01L7/00
CPC分类号： B01L7/52 , B01L2200/0689 , B01L2200/142 , B01L2300/0829 , B01L2300/1827
摘要： A thermal cycler is provided. The thermal cycler comprises a tray assembly. The tray assembly comprises a main body made of a first material having a first thermal conductivity. The tray assembly further comprises an adaptor made of a second material having a thermal conductivity that is greater than the thermal conductivity of the first material. The thermal cycler also includes a control block configured to control the temperature of the one or more nucleotide samples. The thermal cycler further includes a thermal cover sized and positioned to at least partially cover the plurality of vessels. The thermal cycler further includes a sample block including one or more depressions configured to receive a plurality of vessels containing one or more nucleotide samples.
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