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    Novel pharmaceutical compounds and their preparation
    4.
    发明公开
    Novel pharmaceutical compounds and their preparation 失效
    药物活性化合物和它们的制备。

    公开(公告)号：EP0132124A1

    公开(公告)日：1985-01-23

    申请号：EP84304759.8

    申请日：1984-07-12

    申请人： Lilly Industries Limited

    发明人： Steggles, David James ,  Verge, John Pomfret

    IPC分类号： C07D257/04 ,  C07C121/75 ,  C07C121/76 ,  C07C120/00 ,  A61K31/41

    CPC分类号： C07D257/04 ,  C07C45/71 ,  C07C49/84 ,  C07C255/00 ,  C07C331/10

    摘要： Compounds of formula
    wherein R,, R 2 and R 3 are each independently selected from H, OH, C 1 -C 4 alkyl, R 4 -CO and halogen, where R. is C 1 -C 4 alkyl; R 5 and R. are each independently selected from H, C 1 -C 4 alkyl and optionally-substituted phenyl; R 7 is an alkylene group having from 1 to 4 carbon atoms, optionally containing a substituted or unsubstituted phenyl group; p or 0 or 1; and Z is a 1H-tetrazol-5-yl or a -CN group; and salts thereof, may be prepared by reacting a compound of formula.
    with a compound of formula
    wherein R 1 -R 7 are as defined in claim 1, in an organic solvent at a temperature in the range of 40-120°C in the presence of a base, and reacting the resulting compound with an alkali metal cyanide orthiocyanate, and optionally reacting the resulting compound with a source of azide ions to produce pharmacologically active compounds of formula I wherein Z is 1H-tetrazol-5-yl.

    Organic compounds and their pharmaceutical use
    6.
    发明公开
    Organic compounds and their pharmaceutical use 失效
    有机化合物和它们作为补救使用。

    公开(公告)号：EP0110541A1

    公开(公告)日：1984-06-13

    申请号：EP83306378.7

    申请日：1983-10-20

    申请人： Lilly Industries Limited

    发明人： Goldsworthy John ,  Marshall, Winston Stanley ,  Verge, John Pomfret

    IPC分类号： C07D257/04 ,  C07C161/02 ,  A61K31/41

    CPC分类号： C07D257/04

    摘要： There are described compounds of the formula
    in which R 1 is hydrogen or C 1-6 alkyl, R 2 is hydrogen, C 1-6 alkyl or C 3-6 alkenyl, X and Y are each oxygen, sulphur, sulphinyl or sulphonyl, n is 2 to 6 and Z ist IH-tetrazol-5-yl, 1H-tetrazol-5-ylthio, 1H-tetrazol-5-ylsulphinyl, 1H-tetrazol-5-yl- sulphonyl, cyano or thiocyano, provided that when both X and Y are oxygen Z is 1H-tetrazol-5-ylthio, 1H-tetrazol-5-yl- sulphinyl, 1H-tetrazol-5-ylsulphonyl or thiocyano; and salts thereof. The compounds in which Z is other than cyano or thiocyano have pharmaceutical activity and inhibit leukotriene action or formation.

    Tetrazolcarboxanilid derivatives
    7.
    发明公开
    Tetrazolcarboxanilid derivatives 失效
    四唑甲酰苯胺衍生物

    公开(公告)号：EP0147973A1

    公开(公告)日：1985-07-10

    申请号：EP84308608.3

    申请日：1984-12-11

    申请人： Lilly Industries Limited

    发明人： Steggles, David James ,  Verge, John Pomfret

    IPC分类号： C07D257/04

    CPC分类号： C07D257/04 ,  C07C205/37 ,  Y02P20/55

    摘要： There are described compounds of the formula
    in which R' is hydrogen or C 1-6 alkyl, R 2 is hydrogen, C 1-6 alkyl or C 3-6 alkenyl, R 3 is hydrogen or C 1-6 alkyl, R 4 is hydrogen or an N-protecting group, n is 2, 3, 4 or 5, and X is oxygen, sulphur or -CH 2 -, provided that when X is -CH 2 - n is 0; and salts thereof. The compounds in which R 4 is hydrogen have pharmaceutical activity.

    摘要翻译： 描述了下式的化合物，其中R'是氢或C1-6烷基，R2是氢，C1-6烷基或C3-6链烯基，R3是氢或C1-6烷基，R4是氢或N-保护的 基团，n是2,3,4或5，并且X是氧，硫或-CH 2 - ，条件是当X是-CH 2时，n是0; 及其盐。 其中R4是氢的化合物具有药物活性。

    Organic compounds and their pharmaceutical use
    8.
    发明公开
    Organic compounds and their pharmaceutical use 失效
    Organische Verbindung und ihre pharmazeutische Verwendung。

    公开(公告)号：EP0146333A1

    公开(公告)日：1985-06-26

    申请号：EP84308609.1

    申请日：1984-12-11

    申请人： Lilly Industries Limited

    发明人： Goldsworthy, John ,  Verge, John Pomfret

    IPC分类号： C07D257/04 ,  C07C121/75

    CPC分类号： C07D257/04 ,  C07C255/00

    摘要： @ There is described compounds of the formula
    in which R 1 is hydrogen or C 1-6 alkyl, R 2 is hydrogen, C 1-6 alkyl or C 3-6 alkenyl, and X is -CH = CH- or -(CH 2 ) n - where n is 1 to 3, and Y is -CN or
    and salts thereof. The compounds in which Y is tetrazolyl possess pharmaceutical activity.

    摘要翻译： 描述了式的化合物，其中R 1是氢或C 1-6烷基，R 2是氢，C 1-6烷基或C 3-6烯基，X是-CH = CH-或 - （CH 2）n - ，其中n为1至3，Y为-CN或及其盐。 其中Y为四唑基的化合物具有药物活性。