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    GLYCOPOLYSIALYLATION OF PROTEINS OTHER THAN BLOOD COAGULATION PROTEINS
    3.
    发明授权
    GLYCOPOLYSIALYLATION OF PROTEINS OTHER THAN BLOOD COAGULATION PROTEINS 有权
    GLYCOPOLYSIALYLIERUNG VON PROTEINEN ANDERSERS ALS BLUTGERINNUNGSPROTEINEN

    公开(公告)号：EP2459226B1

    公开(公告)日：2016-06-29

    申请号：EP10739386.0

    申请日：2010-07-26

    申请人： Lipoxen Technologies Limited ,  Baxalta Incorporated ,  Baxalta GmbH

    发明人： JAIN, Sanjay ,  GREGORIADIS, Gregory ,  DWIVEDI, Archana ,  NATH, Srijit ,  SIEKMANN, Juergen ,  HAIDER, Stefan ,  ROTTENSTEINER, Hanspeter ,  TURECEK, Peter

    IPC分类号： A61K47/48

    CPC分类号： A61K47/6455 ,  A61K47/60 ,  A61K47/61 ,  A61K47/65

    摘要： A water soluble polymer, in particular polysialic acid (PSA) or a modified PSA (mPSA), is conjugated to an oxidized carbohydrate moiety of a glycoprotein other than a blood coagulation protein or to a ganglioside or drug delivery system by contacting the oxidized carbohydrate moiety with the water soluble polymer, wherein said water soluble polymer contains an aminooxy group and an oxime linkage is formed between the oxidized carbohydrate moiety and the aminooxy group on the water soluble polymer or wherein said water soluble polymer contains a hydrazide group and a hydrazone linkage is formed between the oxidized carbohydrate moiety and the hydrazide group on the water soluble polymer. Conjugates of aminooxy- or hydrazide-water soluble polymer, such as PSA and mPSA, are thus obtained in which the PSA or mPSA is attached via a carbohydrate moiety.

    摘要翻译： 将水溶性聚合物，特别是聚唾液酸（PSA）或修饰的PSA（mPSA）与不同于凝血蛋白的糖蛋白的氧化碳水化合物部分缀合或通过使氧化的碳水化合物部分接触而与神经节苷脂或药物递送系统 其中所述水溶性聚合物含有氨基氧基，并且在水溶性聚合物上的氧化碳水化合物部分和氨基氧基之间形成肟键，或者其中所述水溶性聚合物含有酰肼基，腙键是 形成在水溶性聚合物上的氧化碳水化合物部分和酰肼基团之间。 因此得到氨基氧基或酰肼 - 水溶性聚合物如PSA和mPSA的结合物，其中PSA或mPSA通过碳水化合物部分连接。

    LIPOSOMES CONTAINING OLIGOPEPTIDE FRAGMENTS OF MYELIN BASIC PROTEIN, A PHARMACEUTICAL COMPOSITION AND A METHOD FOR TREATMENT OF MULTIPLE SCLEROSIS
    6.
    发明公开
    LIPOSOMES CONTAINING OLIGOPEPTIDE FRAGMENTS OF MYELIN BASIC PROTEIN, A PHARMACEUTICAL COMPOSITION AND A METHOD FOR TREATMENT OF MULTIPLE SCLEROSIS 有权
    与寡肽髓鞘碱性蛋白，药物用于治疗多发性硬化症的组成和方法LIPOSOME

    公开(公告)号：EP2836229A1

    公开(公告)日：2015-02-18

    申请号：EP13715237.7

    申请日：2013-04-11

    申请人： Lipoxen Technologies Limited

    发明人： GABIVOV, Alexander ,  BELOGUROV, Alexey ,  PONOMARENKO, Natalia ,  SMIRNOV, Ivan ,  BACON, Andrew ,  GREGORIADIS, Gregory

    IPC分类号： A61K39/00 ,  A61K9/127 ,  C07K14/47

    CPC分类号： A61K9/127 ,  A61K39/0008 ,  C07K14/4713

    摘要： A composition for the treatment of multiple sclerosis comprises a first myelin basic protein (MBP) peptide linked to a first vector, the first MBP peptide consisting of the amino acid sequence: (R1)a-P1-R2)b wherein P1 is an amino acid sequence having at least 85% identity to an amino acid sequence selected from the group consisting of SEQ ID NOS:1-3; each of R1 and R2 are amino acid sequences independently consisting of from 1 to 10 amino acids; and each of a and b are independently zero or one. Compositions of immunodominant peptides of myelin basic protein are encapsulated in mannosylated liposomes. In a specific embodiment, the compositions comprise mylein basic protein (MBP) peptides MBP(46-62), MBP(124-139), and MBP(147-170).

    摘要翻译： 一种用于多发性硬化的治疗组合物包括连接于第一向量的第一髓鞘碱性蛋白（MBP）肽，所述第一肽MBP由氨基酸序列组成：（R1）一个P1-R2）b worin P1是氨基 具有至少85％的同一性，在选自由SEQ ID NOS的选择的氨基酸序列氨基酸序列：1-3; 每个R1和R2是氨基酸1至10个氨基酸的unabhängig由...组成的氨基酸序列; 以及每个a和bunabhängig0或1。 髓鞘碱性蛋白的免疫肽成分被封装在甘露脂质体。 在一个具体的实施方案中，组合物包含mylein碱性蛋白（MBP）肽MBP（46-62），MBP（124-139），和MBP（147-170）。