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公开(公告)号：EP3359706A1
公开(公告)日：2018-08-15
申请号：EP16751563.4
申请日：2016-08-08
IPC分类号： C23C16/455 , C23C16/40
CPC分类号： C23C16/45534 , C23C16/402 , C23C16/45527
摘要： A process of atomic layer deposition for the deposition of silicon oxide on a substrate, performed at room temperature, involving at least three precursors, being silicon tetrachloride, water and one Lewis base agent, being in various instances ammonia. The process comprises the steps of exposing on the substrate during an exposure time (a) the one Lewis base agent, (b) the silicon tetrachloride, and (c) the water. The process is remarkable in that at least one step of purge with nitrogen gas is performed after each of the steps (a), (b) and (c) during a purge time. Additionally, a film of silicon oxide which is remarkable in that it comprises a low level of chlorine contaminant and a significant degree of porosity with pores, the pores being in various instances micropores, mesopores or nanopores.
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2.发明公开
公开(公告)号：EP3191147A1
公开(公告)日：2017-07-19
申请号：EP15762613.6
申请日：2015-09-10
CPC分类号： A61L27/306 , A61B5/04001 , A61B5/686 , A61L2400/18 , A61L2430/32 , A61N1/3605 , A61N1/375 , H01L21/3065 , H01L29/2003
摘要： According to the present invention, an implantable device is provided, comprising a substrate on which at least one surface portion is provided. The chemical composition of the surface portion selectively enhances the cell-adhesion to the substrate.
摘要翻译： 根据本发明，提供了一种可植入装置，其包括其上设置有至少一个表面部分的基底。 表面部分的化学组成选择性地增强了与基材的细胞粘附。
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3.发明公开
公开(公告)号：EP3519161A1
公开(公告)日：2019-08-07
申请号：EP17771783.2
申请日：2017-09-28
发明人： ISHCHENKO, Olga , LENOBLE, Damien
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4.发明公开
公开(公告)号：EP3325407A1
公开(公告)日：2018-05-30
申请号：EP16750400.0
申请日：2016-07-20
IPC分类号： C01B37/02
CPC分类号： C01B33/193 , B82Y5/00 , B82Y40/00 , C01B37/02 , C01P2004/64 , C01P2006/16
摘要： A method for self-assembling a mesoporous silica nanoparticle. The method comprises the step of condensing a silica precursor, a surfactant and a condensation agent in a solvent. Then, the addition of an organotriethoxysilane is performed. Finally, there is the step of removing the surfactant. The method is remarkable in that the portion of the organotriethoxysilane to the silica precursor is comprised between 5% and 15%. Additionally, a self-assembled mesoporous silica nanoparticle comprising at least one silica precursor and an organotriethoxysilane.
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公开(公告)号：EP4457381A1
公开(公告)日：2024-11-06
申请号：EP22847126.4
申请日：2022-12-09
发明人： POLESEL, Jérôme , LENOBLE, Damien
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6.发明公开
公开(公告)号：EP3688812A1
公开(公告)日：2020-08-05
申请号：EP18773216.9
申请日：2018-09-27
IPC分类号： H01L29/66 , H01L29/786 , H01L21/16 , H01L29/24
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公开(公告)号：EP3679427A1
公开(公告)日：2020-07-15
申请号：EP18769633.1
申请日：2018-09-07
发明人： SPIRITO, David , LENOBLE, Damien
IPC分类号： G03F7/00
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公开(公告)号：EP3519606A1
公开(公告)日：2019-08-07
申请号：EP17777866.9
申请日：2017-09-27
IPC分类号： C23C16/40 , H01L21/285 , H01L29/786
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公开(公告)号：EP3324940A1
公开(公告)日：2018-05-30
申请号：EP16742296.3
申请日：2016-07-22
CPC分类号： A61K9/1271 , A61K8/14 , A61K9/127 , A61K9/1277 , A61K9/5115 , A61K49/0002 , A61Q19/00
摘要： A method for manufacturing a negatively charged supported lipid bilayer. The method comprises the steps of preparing a formulation comprising at least three lipids (1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS), cholesterol and at least one lipid different from DOPS and cholesterol) dissolved in a first solvent, of evaporating the first solvent, of adding an aqueous formulation of mesoporous silica nanoparticles, of performing an ultra-sonication and of performing a centrifugation. The method is remarkable in that the number of equivalents of cholesterol relative to one equivalent of DOPS is comprised between 2.30 and 2.70. Additionally, negatively charged supported lipid bilayer on a mesoporous silica nanoparticle comprising cholesterol, 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS) and at least one lipid different from DOPS and cholesterol.
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