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1.发明公开ASTHMA ASSOCIATED FACTORS AS TARGETS FOR TREATING ATOPIC ALLERGIES INCLUDING ASTHMA AND RELATED DISORDERS 审中-公开哮喘相关因素的定位元素治疗特异反应性过敏，包括哮喘和相关疾病
公开(公告)号：EP1025223A2
公开(公告)日：2000-08-09
申请号：EP98948311.0
申请日：1998-09-18
IPC分类号： C12N15/12 , C12N15/11 , C12N15/70 , C12N1/21 , C07K14/705 , C07K16/28 , A61K31/70 , A61K39/395 , G01N33/53
CPC分类号： C07K14/705 , A61K38/00
摘要： A new gene in the G-coupled protein receptor family is discribed that is induced by IL-9, thereby providing a therapeutic target in IL-9 mediated development of atopic allergy, asthma-related disorders and certain lymphomas or leukemias. A method for recombinantly producing the polypeptide encoded by the gene is disclosed. A method for identification and use of agonist and antagonists of GCR9 to treat atopic allergy, asthma-related disorders and certain lymphomas or leukemias is also included. A method for diagnosing susceptibility to, and assessing treatment of atopic allergy, asthma-related disorders and certain lymphomas or leukemias by measuring the level of GCR9 in biological samples using antibody specific for the GCR9 polypeptide or nucleic acid probes specific for GCR9 nucleic acids is also disclosed.
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2.发明公开ASTHMA ASSOCIATED FACTORS AS TARGETS FOR TREATING ATOPIC ALLERGIES INCLUDING ASTHMA AND RELATED DISORDERS 审中-公开支气管哮喘相关因素，如特应性目标过敏的治疗包括哮喘和相关疾病
公开(公告)号：EP1067940A1
公开(公告)日：2001-01-17
申请号：EP99911092.7
申请日：1999-03-03
发明人： HOLROYD, Kenneth, J. , LEVITT, Roy, C. , MALOY, W., Lee , LOUAHED, Jamila , McLANE, Mike , NICOLAIDES, Nicholas, C. , ZHOU, Yuhong , DONG, Qu
IPC分类号： A61K31/70 , A61K39/395 , C07H21/04 , G01N33/53
CPC分类号： C07K14/705 , A61K38/00 , G01N33/6872 , G01N2500/00 , Y10S977/914 , Y10S977/927
摘要： A new gene in the calcium-activated chloride channel family has been discovered that is induced by IL-9, thereby providing a therapeutic target in IL-9 mediated development of atopic allergy, asthma-related disorders and cystic fibrosis. A method for the identification and use of small molecule inhibitors of this gene and its products to treat these disorders has also been discovered. The invention also includes a method for diagnosing susceptibility to, and assessing treatment of atopic allergy, asthma-related disorders by measuring the level of gene expression in biologic samples using antibody specific for this protein.
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