公开(公告)号：EP1730286A2

公开(公告)日：2006-12-13

申请号：EP05724526.8

申请日：2005-03-04

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  Lankenau Institute for Medical Research

发明人： ANDERSON, Daniel, Griffith ,  LANGER, Robert ,  SAWICKI, Janet ,  PENG, Weidan

IPC分类号： C12N15/74 ,  A61K31/70

CPC分类号： C12N15/88 ,  A61K48/0058 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2800/30 ,  C12N2830/008 ,  C12N2830/15

摘要： Aspects of the invention relate to nucleic acids molecules that are useful for specifically destroying selected cells, tissues, or organs. Aspects of the invention are useful for treating diseases (e.g., cancer) that affect cells, tissues, or organs.

公开(公告)号：EP2691443A2

公开(公告)日：2014-02-05

申请号：EP12724782.3

申请日：2012-03-23

申请人： Massachusetts Institute Of Technology

发明人： DAHLMAN, James, E. ,  SCHROEDER, Avraham, D. ,  ANDERSON, Daniel, Griffith ,  LANGER, Robert, S. ,  LEVINS, Christopher, G.

IPC分类号： C08G73/10

CPC分类号： A61K47/22 ,  A61K9/0019 ,  A61K9/1272 ,  A61K47/34 ,  A61K47/543 ,  A61K47/59 ,  A61K47/6907 ,  A61K47/6911 ,  A61K47/6921 ,  C07D257/02 ,  C07D273/00 ,  C07D273/08 ,  C07D295/084 ,  C08G73/10 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2320/32

摘要： The present invention provides inventive conjugated polyethyleneimine (PEI) polymers and conjugated aza-macrocycles (collectively referred to herein as “conjugated lipomers” or “lipomers”) containing one or more groups of the formula (iii): wherein R3 and R4 are as defined herein. Also provided are compositions comprising the inventive conjugated lipomers, and methods of preparation and use.

公开(公告)号：EP2205725A2

公开(公告)日：2010-07-14

申请号：EP08834284.5

申请日：2008-09-29

申请人： Massachusetts Institute of Technology

发明人： KARNIK, Rohit, Nandkumar ,  HONG, Seungpyo ,  MEI, Ying ,  ANDERSON, Daniel, Griffith ,  KARP, Jeffrey, Michael ,  LANGER, Robert, S. ,  BOSE, Suman

IPC分类号： C12N5/08 ,  C12M1/00 ,  C07K16/28

CPC分类号： C12N5/0068 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0877 ,  B01L2300/16 ,  C12M23/16 ,  C12M47/02 ,  C12N5/0062 ,  C12N2501/58 ,  C12N2501/585 ,  C12N2533/50 ,  C12N2533/52 ,  C12N2535/10

摘要： The present invention provides systems for cell separation based on cell rolling on surfaces along edges of regions coated with cell adhesion molecules. A variety of designs of coated regions and edges are disclosed.

公开(公告)号：EP3703760A1

公开(公告)日：2020-09-09

申请号：EP18822171.7

申请日：2018-11-02

申请人： Massachusetts Institute Of Technology ,  Politecnico di Milano

发明人： CAPASSO PALMIERO, Umberto ,  KACZMAREK, James, C. ,  ANDERSON, Daniel, Griffith ,  MOSCATELLI, Davide

IPC分类号： A61K47/34 ,  A61K9/51 ,  C08G73/02 ,  C08G63/685

公开(公告)号：EP2882706A1

公开(公告)日：2015-06-17

申请号：EP13751043.4

申请日：2013-08-13

申请人： Massachusetts Institute of Technology

发明人： ANDERSON, Daniel, Griffith ,  WHITEHEAD, Kathryn, Ann ,  DORKIN, Joseph, R. ,  VEGAS, Arturo, Jose ,  ZHANG, Yunlong ,  LANGER, Robert, S.

IPC分类号： C07C229/12 ,  C07C229/14 ,  C07D295/13 ,  C07D211/14 ,  C07D319/18 ,  C07D207/09 ,  C07D211/26 ,  C07D487/04 ,  A61K47/18 ,  A61K9/127 ,  A61K9/51 ,  A61K31/496 ,  C12N15/11 ,  C12N15/88

CPC分类号： A61K47/22 ,  A61K9/1272 ,  A61K9/5123 ,  A61K31/225 ,  A61K31/357 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495 ,  A61K31/4985 ,  A61K31/573 ,  A61K31/704 ,  A61K31/713 ,  A61K45/06 ,  A61K47/18 ,  A61K47/542 ,  A61K47/543 ,  A61K47/6925 ,  C07C225/06 ,  C07C229/12 ,  C07C229/14 ,  C07C229/24 ,  C07C229/26 ,  C07C229/28 ,  C07C229/34 ,  C07C2601/14 ,  C07D207/09 ,  C07D211/14 ,  C07D211/26 ,  C07D211/34 ,  C07D241/04 ,  C07D295/13 ,  C07D295/15 ,  C07D295/16 ,  C07D319/16 ,  C07D319/18 ,  C07D487/04 ,  C12N15/111 ,  C12N15/1137 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32 ,  A61K2300/00

摘要： Provided herein are lipidoids that may be prepared from the conjugate addition of alkylamines to acrylates. In some embodiments, provided lipidoids are biodegradable and may be used in a variety of drug delivery systems. Given the amino moiety of the lipidoids, they are well-suited for the delivery of polynucleotides, in addition to other agents. Nanoparticles containing the inventive lipidoids and polynucleotides have been prepared and have been shown to be effective in delivering siRNA.

摘要翻译： 本文提供的是可以通过将烷基胺偶联加成丙烯酸酯制备的类脂。 在一些实施方案中，提供的类脂质是可生物降解的并且可以用于多种药物递送系统中。 考虑到类固醇的氨基部分，除了其它药剂之外，它们非常适合于递送多核苷酸。 已经制备了含有本发明的类脂和多核苷酸的纳米颗粒，并已显示其有效递送siRNA。

公开(公告)号：EP2771319A1

公开(公告)日：2014-09-03

申请号：EP12783791.2

申请日：2012-10-26

申请人： Massachusetts Institute Of Technology

发明人： DONG, Yizhou ,  LOVE, Kevin, Thomas ,  LANGER, Robert, S. ,  ANDERSON, Daniel, Griffith ,  CHEN, Delai ,  CHEN, Yi ,  VEGAS, Arturo, Jose ,  ALABI, Akinleye ,  ZHANG, Yunlong

IPC分类号： C07D207/16 ,  C07D209/20 ,  C07D233/64 ,  C07D241/08 ,  C07D403/06 ,  C07D487/06 ,  C07C227/18 ,  C07C229/12 ,  C07C229/16 ,  C07C229/22 ,  C07C229/26 ,  C07C229/28 ,  A61K48/00 ,  C12N15/87

CPC分类号： A61K31/7105 ,  A61K31/711 ,  A61K47/22 ,  A61K2121/00 ,  C07C229/12 ,  C07C229/22 ,  C07C229/24 ,  C07C229/26 ,  C07C229/36 ,  C07C237/08 ,  C07C237/12 ,  C07C271/22 ,  C07C279/14 ,  C07C323/58 ,  C07D207/16 ,  C07D209/20 ,  C07D209/24 ,  C07D233/64 ,  C07D241/08 ,  C07D265/32 ,  C07D403/06 ,  C07D413/06 ,  C07D487/04 ,  C07D487/06 ,  C12N15/87 ,  C12N15/88 ,  C12Q1/025 ,  G01N33/15

摘要： Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as "APPLs". Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R', R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.

摘要翻译： worin M，N，P，R”，R1，R2，R3，R4，R5，R8，Z，W，Y，和Z如在定义。

公开(公告)号：EP2609135A2

公开(公告)日：2013-07-03

申请号：EP11820727.3

申请日：2011-08-26

申请人： Massachusetts Institute Of Technology

发明人： MA, Minglin ,  LIU, Wendy, F. ,  LANGER, Robert, S. ,  ANDERSON, Daniel, Griffith

IPC分类号： C08G73/00 ,  C08G65/22 ,  A61K31/16 ,  A61L31/10 ,  C09D5/14

CPC分类号： C08G73/0206 ,  A61K9/1273 ,  A61K31/7088 ,  A61K47/34 ,  A61K47/59 ,  A61L31/10 ,  C08G59/22 ,  C08G59/306 ,  C08G59/50 ,  C08G73/02 ,  C09D5/1637 ,  C09D179/02 ,  Y10T428/31725

摘要： A new class of poly(beta-amino alcohols) (PBAAs) has been prepared using combinatorial polymerization. The inventive PBAAs may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. When used as surface coatings, these PBAAs elicited different levels of inflammation, both in vitro and in vivo, depending on their chemical structures. The large chemical diversity of this class of materials allowed us to identify polymer coatings that inhibit macrophage activation in vitro. Furthermore, these coatings reduce the recruitment of inflammatory cells, and reduce fibrosis, following the subcutaneous implantation of carboxylated polystyrene microparticles. These polymers may be used to form polyelectrolyte complex capsules for cell encapsulation. The invention may also have many other biological applications such as antimicrobial coatings, DNA or siRNA delivery, and stem cell tissue engineering.

公开(公告)号：EP3310764A1

公开(公告)日：2018-04-25

申请号：EP16736955.2

申请日：2016-06-17

申请人： Massachusetts Institute of Technology

发明人： ANDERSON, Daniel, Griffith ,  DORKIN, Joseph, R. ,  FENTON, Owen, Shea ,  KAUFFMAN, Kevin, John ,  MCCLELLAN, Rebecca, L.

IPC分类号： C07D241/08

CPC分类号： A61K48/0033 ,  A61K38/1816 ,  A61K47/545 ,  C07D241/08

摘要： Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.

公开(公告)号：EP2365962B1

公开(公告)日：2017-07-05

申请号：EP09825132.5

申请日：2009-11-06

申请人： Massachusetts Institute of Technology

发明人： MAHON, Kerry, Peter ,  LOVE, Kevin, Thomas ,  LEVINS, Christopher, G. ,  WHITEHEAD, Kathryn, Ann ,  LANGER, Robert, S. ,  ANDERSON, Daniel, Griffith

IPC分类号： A61K48/00 ,  C12N15/11 ,  C07D295/13

CPC分类号： C07D295/13 ,  A61K9/107 ,  A61K9/1271 ,  A61K9/5123 ,  A61K31/7088 ,  A61K38/02 ,  A61K47/16 ,  A61K47/54 ,  A61K47/545 ,  A61K48/0025 ,  B01J2531/0252 ,  B01J2531/845 ,  C07C215/14 ,  C07C217/08 ,  C12N15/111 ,  C12N15/1137 ,  C12N15/88 ,  C12N2310/14 ,  C12N2310/3515 ,  C12N2320/32

摘要： Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

公开(公告)号：EP2791210A1

公开(公告)日：2014-10-22

申请号：EP12809954.6

申请日：2012-12-15

申请人： Massachusetts Institute of Technology

发明人： VEGAS, Arturo, Jose ,  WHITEHEAD, Kathryn, Ann ,  ANDERSON, Daniel, Griffith ,  LANGER, Robert, S. ,  DORKIN, Joseph, R.

IPC分类号： C08G73/00 ,  C08L79/00 ,  A61K9/127 ,  A61K47/34 ,  A61K9/51 ,  C12N15/88

CPC分类号： A61K47/34 ,  A61K9/1271 ,  A61K9/5146 ,  A61K31/713 ,  A61K33/00 ,  A61K38/16 ,  A61K39/00 ,  C08G12/06 ,  C08G12/34 ,  C08G73/00 ,  C08L79/00 ,  C12N15/113

摘要： α-Aminoamidine polymers and methods of preparing a-aminoamidine polymers by reacting by reacting one or more amines with one or more isocyanides and one or more aldehydes are described. Methods of preparing a-aminoamidine polymers from commercially available starting materials are also provided, wherein the starting materials are racemic or stereochemically pure. a-Aminoamidine polymers or salt forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems and for other purposes as well such as, for example, coatings, additives, excipients, plastics, and materials, etc. Given the amino moiety of these α-aminoamidine polymers, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive α-aminoamidine polymers and polynucleotides can be prepared. The inventive α-aminoamidine polymers may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

摘要翻译： 描述了α-氨基脒聚合物和通过使一种或多种胺与一种或多种异氰化物和一种或多种醛反应来制备α-氨基脒聚合物的方法。 还提供了由市售原料制备α-氨基脒聚合物的方法，其中原料是外消旋或立体化学纯的。 α-氨基脒聚合物或其盐形式优选是可生物降解的和生物相容的，并且可以用于多种药物递送系统中以及用于其他目的，例如涂料，添加剂，赋形剂，塑料和材料等。给定的 这些α-氨基脒聚合物的氨基部分，它们特别适合于递送多核苷酸。 可以制备含有本发明的α-氨基脒聚合物和多核苷酸的复合物，胶束，脂质体或颗粒。 本发明的α-氨基脒聚合物也可以用于制备用于药物递送的微粒。 考虑到它们缓冲周围环境pH的能力，它们在提供不稳定剂方面特别有用。