-
1.发明公开CHEMICAL LINKERS AND CLEAVABLE SUBSTRATES AND CONJUGATES THEREOF 审中-公开化学品连接器在IHRE KONJUGATE上进行了基础研究
公开(公告)号：EP2114454A2
公开(公告)日：2009-11-11
申请号：EP07870071.3
申请日：2007-12-28
申请人： MEDAREX, INC.
发明人： SUFI, Bilal , GUERLAVAIS, Vincent , CHEN, Liang , GANGWAR, Sanjeev , ZHANG, Qian , PASSMORE, David, B.
IPC分类号： A61K47/00
CPC分类号： C07K5/06052 , A61K47/552 , A61K47/556 , A61K47/65 , A61K47/6809 , A61K47/6851 , A61K49/0002 , C07D403/14 , C07D487/04 , C07K5/06078 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/1008
摘要： The present disclosure provides drug-ligand conjugates and drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
摘要翻译： 本公开提供了药物 - 配体缀合物和药物可切割底物缀合物，其是有效的细胞毒素。 本公开还涉及含有药物 - 配体缀合物的组合物以及使用它们的治疗方法。
-
公开(公告)号：EP1940470B1
公开(公告)日：2013-04-17
申请号：EP06825196.6
申请日：2006-09-26
申请人： Medarex, Inc.
发明人： BOYD, Sharon, Elaine , CHEN, Liang , GANWAR, Sanjeev , GUERLAVAIS, Vincent , HORGAN, Kilian , SUFI, Bilal , CARDARELLI, Josephine, M. , PAN, Chin , HUANG, Haichun , KING, David, John
CPC分类号： C07K5/06052 , A61K38/00 , A61K47/6803 , A61K47/6805 , A61K47/6809 , A61K47/6869 , A61K47/6889 , B82Y30/00
-
公开(公告)号：EP1948242B9
公开(公告)日：2012-02-08
申请号：EP06839792.6
申请日：2006-11-09
申请人： Medarex, Inc.
发明人： GANGWAR, Sanjeev , SUFI, Bilal
IPC分类号： C07D487/00 , A61P35/00
CPC分类号： C07D405/06 , A61K47/552 , A61K47/64 , A61K47/65 , C07D405/14
摘要： The present disclosure provides cytoxic compounds useful as drugs or prodrugs and to drug-cleavable substrate conjugates where the drug and cleavable substrate are optionally linked through a self-immolative linker.
-
4.发明公开CYTOTOXIC COMPOUNDS AND CONJUGATES COMPRISING DUOCARMYCINS WITH CLEAVABLE SUBSTRATES 审中-公开细胞毒性化合物和缀合物裂变SUBSTRATES卡霉素
公开(公告)号：EP1865991A2
公开(公告)日：2007-12-19
申请号：EP06749436.9
申请日：2006-04-07
申请人： MEDAREX, INC.
发明人： GANGWAR, Sanjeev , SUFI, Bilal
IPC分类号： A61K47/48 , C07D405/06 , A61P35/00
CPC分类号： C07D405/06 , A61K47/65 , C07D405/14
摘要： The present disclosure provides drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-cleavable substrate conjugates, and to methods of treatment using them.
-
公开(公告)号：EP1948242B1
公开(公告)日：2011-09-14
申请号：EP06839792.6
申请日：2006-11-09
申请人： Medarex, Inc.
发明人： GANGWAR, Sanjeev , SUFI, Bilal
IPC分类号： C07D487/00 , A61P35/00
CPC分类号： C07D405/06 , A61K47/552 , A61K47/64 , A61K47/65 , C07D405/14
摘要： The present disclosure provides cytoxic compounds useful as drugs or prodrugs and to drug-cleavable substrate conjugates where the drug and cleavable substrate are optionally linked through a self-immolative linker.
-
公开(公告)号：EP1948242A2
公开(公告)日：2008-07-30
申请号：EP06839792.6
申请日：2006-11-09
申请人： MEDAREX, INC.
发明人： GANGWAR, Sanjeev , SUFI, Bilal
IPC分类号： A61K47/48 , C07D487/00 , A61P35/00
CPC分类号： C07D405/06 , A61K47/552 , A61K47/64 , A61K47/65 , C07D405/14
摘要： The present disclosure provides cytoxic compounds useful as drugs or prodrugs and to drug-cleavable substrate conjugates where the drug and cleavable substrate are optionally linked through a self-immolative linker.
-
公开(公告)号：EP1940470A2
公开(公告)日：2008-07-09
申请号：EP06825196.6
申请日：2006-09-26
申请人： Medarex, Inc.
发明人： BOYD, Sharon, Elaine , CHEN, Liang , GANWAR, Sanjeev , GUERLAVAIS, Vincent , HORGAN, Kilian , SUFI, Bilal , CARDARELLI, Josephine, M. , PAN, Chin , HUANG, Haichun , KING, David, John
CPC分类号： C07K5/06052 , A61K38/00 , A61K47/6803 , A61K47/6805 , A61K47/6809 , A61K47/6869 , A61K47/6889 , B82Y30/00
摘要： The present disclosure provides antibody-drug conjugates that are potent cytotoxins, wherein the drug is linked to the antibody through a linker. The disclosure is also directed to compositions containing the antibody-drug conjugates, and to methods of treatment using them.
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.015 秒)
