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公开(公告)号：EP2393921A1
公开(公告)日：2011-12-14
申请号：EP10705688.9
申请日：2010-02-05
IPC分类号： C12N7/00 , A61K35/76 , C07K14/125 , C07K14/11
CPC分类号： C12N7/00 , A61K35/13 , A61K39/0011 , A61K39/17 , C07K14/005 , C12N2760/16122 , C12N2760/18121 , C12N2760/18122 , C12N2760/18132 , C12N2760/18143 , C12N2760/18171
摘要： The invention provides chimeric Newcastle disease viruses (NDV) engineered to express a heterologous interferon antagonist, a modified F protein, and a cytokine. Further provided are pharmaceutical compositions comprising such chimeric viruses, methods for producing said pharmaceutical compositions and their use in a method for treating cancer in a subject. Provided are also cells and non-human embryonated eggs comprising the chimeric NDV viruses of the invention.
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公开(公告)号：EP1979000B1
公开(公告)日：2011-07-13
申请号：EP06847911.2
申请日：2006-12-21
发明人： FONG, Yuman , ADUSUMILLI, Prasad S.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6897 , A61K35/13 , C12N2710/16611 , C12N2710/24111 , G01N33/574
摘要： The invention relates to compositions and methods for cancer cell detection in bodily samples wherein a cancer cell can be detected within a mixed population of cancer cells and non-cancer cells. The invention also relates to compositions and methods that may be used in cancer cell detection, specifically viruses that are replication-competent conditional to a cancer cell, in particular an oncolytic herpes virus, such as NV 1066 and a vaccinia virus, such as GLV-lh68. Provided are methods and kits for using these viruses that preferentially replicate in cancer cells and may also preferentially infect cancer cells for specific identification of such cancer cells, even when a cancer cell is present, for example, at a ratio of one infected cancer cell in a background often thousand non-cancer cells, thus further providing a reproducible and sensitive screening method for cancer detection, monitoring and prognosis.
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公开(公告)号：EP1979000A2
公开(公告)日：2008-10-15
申请号：EP06847911.2
申请日：2006-12-21
发明人： FONG, Yuman , ADUSUMILLI, Prasad
IPC分类号： A61K39/395 , C12Q1/70 , G01N33/574
CPC分类号： C12Q1/6897 , A61K35/13 , C12N2710/16611 , C12N2710/24111 , G01N33/574
摘要： The invention relates to compositions and methods for cancer cell detection in bodily samples wherein a cancer cell can be detected within a mixed population of cancer cells and non-cancer cells. The invention also relates to compositions and methods that may be used in cancer cell detection, specifically viruses that are replication-competent conditional to a cancer cell, in particular an oncolytic herpes virus, such as NV 1066 and a vaccinia virus, such as GLV-lh68. Provided are methods and kits for using these viruses that preferentially replicate in cancer cells and may also preferentially infect cancer cells for specific identification of such cancer cells, even when a cancer cell is present, for example, at a ratio of one infected cancer cell in a background often thousand non-cancer cells, thus further providing a reproducible and sensitive screening method for cancer detection, monitoring and prognosis.
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公开(公告)号：EP2987856B1
公开(公告)日：2018-07-25
申请号：EP15162322.0
申请日：2010-02-05
IPC分类号： C12N7/00 , A61K35/76 , C07K14/125 , C07K14/11
CPC分类号： C12N7/00 , A61K35/13 , A61K39/0011 , A61K39/17 , C07K14/005 , C12N2760/16122 , C12N2760/18121 , C12N2760/18122 , C12N2760/18132 , C12N2760/18143 , C12N2760/18171
摘要： The invention provides chimeric Newcastle disease viruses (NDV) engineered to express a heterologous interferon antagonist, a modified F protein, and a cytokine. Further provided are pharmaceutical compositions comprising such chimeric viruses, methods for producing said pharmaceutical compositions and their use in a method for treating cancer in a subject. Provided are also cells and non-human embryonated eggs comprising the chimeric NDV viruses of the invention.
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公开(公告)号：EP2393921B1
公开(公告)日：2015-07-15
申请号：EP10705688.9
申请日：2010-02-05
IPC分类号： C12N7/00 , A61K35/76 , C07K14/125 , C07K14/11
CPC分类号： C12N7/00 , A61K35/13 , A61K39/0011 , A61K39/17 , C07K14/005 , C12N2760/16122 , C12N2760/18121 , C12N2760/18122 , C12N2760/18132 , C12N2760/18143 , C12N2760/18171
摘要： The invention provides chimeric Newcastle disease viruses (NDV) engineered to express a heterologous interferon antagonist, a modified F protein, and a cytokine. Further provided are pharmaceutical compositions comprising such chimeric viruses, methods for producing said pharmaceutical compositions and their use in a method for treating cancer in a subject. Provided are also cells and non-human embryonated eggs comprising the chimeric NDV viruses of the invention.
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