公开(公告)号：EP1129089A4

公开(公告)日：2003-01-22

申请号：EP99971808

申请日：1999-11-08

申请人： MERCK & CO INC ,  BANYU PHARMA CO LTD

发明人： GAO YING-DUO ,  MACNEIL DOUGLAS J ,  YANG LIHU ,  MORIN NANCY R ,  FUKAMI TAKEHIRO ,  KANATANI AKIO ,  FUKURODA TAKAHIRO ,  ISHII YASUYUKI ,  MORIN MASAKI

IPC分类号： A61K31/403 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4375 ,  A61K31/438 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/498 ,  A61K31/501 ,  A61K31/506 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P7/04 ,  A61P9/04 ,  A61P13/02 ,  A61P15/00 ,  A61P19/02 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P37/02 ,  C07D209/96 ,  C07D221/20 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04 ,  C07D471/10 ,  C07D471/20 ,  C07D487/10 ,  C07D487/20 ,  C07D519/00 ,  C07C233/58 ,  C07D209/54 ,  C07D211/98 ,  C07D233/70 ,  C07D261/20 ,  C07D277/64 ,  C07D285/08 ,  C07D333/36 ,  C07D401/08

CPC分类号： C07D221/20 ,  C07D471/10

公开(公告)号：EP1264826A4

公开(公告)日：2003-03-19

申请号：EP01906215

申请日：2001-02-22

申请人： BANYU PHARMA CO LTD

发明人： SATO NAGAAKI ,  OKAMOTO OSAMU ,  JITSUOKA MAKOTO ,  NAGAI KEITA ,  KANATANI AKIO ,  ISHIHARA AKANE ,  ISHII YASUYUKI ,  FUKAMI TAKEHIRO

IPC分类号： C07D233/26 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/427 ,  A61K31/433 ,  A61K31/4375 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/506 ,  C07D403/14 ,  C07D409/04

CPC分类号： C07D401/04 ,  C07D233/26 ,  C07D401/14 ,  C07D403/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04

摘要： Compounds represented by the general formula (I): (wherein Ar?1 and Ar2¿ are each aryl or heteroaryl; R1 is lower cycloalkyl, -Ar3, or a group of the general formula (a), (b) or (c): and R?2 and R3¿ are each hydrogen, lower cycloalkyl, lower alkenyl, or optionally substituted lower alkyl (with the proviso that when R?2 and R3¿ are simultaneously hydrogen, Ar?1, Ar2 and R1¿ do not simultaneously represent unsubstituted phenyl). The compounds are useful as treating agents for various NPY-related diseases, for example, circulatory diseases including hypertension, kidney diseases, cardiac diseases, vasospasm and arteriosclerosis; central nervous system diseases including hyperphagia, depression, anxiety, convulsion, epilepsy, dementia, pain, alcohol dependence, and withdrawal symptoms due to abstinence from drugs; metabolic diseases including obesity, diabetes, hormonal disorders, hypercholesterolemia, and hyperlipidemia; sexual dysfunction and reproductive function disorders; digestive diseases including enterokinetic disorders; respiratory diseases; inflammation; or glaucoma.

公开(公告)号：EP1935985A4

公开(公告)日：2009-03-11

申请号：EP06810346

申请日：2006-09-13

申请人： BANYU PHARMA CO LTD

发明人： TAKAHASHI HIROYUKI ,  INOUE KAZUKO ,  SHIBATA YOSHIHIRO ,  CHIBA MASATO ,  ISHII YASUYUKI

IPC分类号： C12Q1/25 ,  G01N33/60 ,  G21H5/02

CPC分类号： G21H5/02 ,  G01N33/60

摘要： A method of detecting a reactive metabolite which involves the reaction step wherein a metabolic reaction of a test compound is conducted in the presence of two labeled nucleophiles and the detection step wherein the label of the nucleophile bonded to the reactive metabolite is detected; and a method of detecting a reactive metabolite which further involves the separation step wherein a liquid layer separation is conducted by using ammonium acetate to give an organic layer after the completion of the reaction step as described above. Use of these detection methods makes it possible to quantitatively detect a reactive metabolite while using convenient preparation procedures. Moreover, it becomes possible thereby to avoid the formation of false positive signals and lessen the formation of false negative signals. As a result, a test compound can be more accurately and more efficiently screened.