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公开(公告)号：EP1017709A1
公开(公告)日：2000-07-12
申请号：EP98951942.6
申请日：1998-09-24
申请人： MERCK & CO., INC.
IPC分类号： C07H21/04
CPC分类号： G01N33/5091 , A01K2217/05 , A01K2217/075 , C07K14/723 , G01N33/5008 , G01N33/502 , G01N2333/726
摘要： This invention provides a novel G-protein coupled glycoprotein hormone receptor AOMF05, mutant and polymorphic forms of the receptor, nucleic acids encoding the same, expression vectors including the nucleic acids, host cells transformed with nucleic acids, transgenic knockout animals lacking the receptor and transgenic animals expressing a non-native receptor gene, antibodies against the receptor and polypeptides thereof and assays for modulators, agonists and antagonists of the receptor. The receptor proteins and polypeptides, nucleic acids, cells, animals and assays of this invention are useful in drug screening and development, diagnosis and therapeutic applications.
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公开(公告)号：EP1685379A2
公开(公告)日：2006-08-02
申请号：EP04801804.8
申请日：2004-07-09
申请人： Merck & Co., Inc.
IPC分类号： G01N1/00
CPC分类号： G01N33/502 , G01N33/5008 , G01N33/5032 , G01N33/5038 , G01N33/5041 , G01N33/6872 , G01N33/9406 , G01N2333/70571
摘要： The present invention makes available a rapid, effective assay for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a target cell surface protein, e.g., a receptor or ion channel. The subject assay enables rapid screening of large numbers of compounds to identify those which modulate the bioactivity of the cellular proteins. The subject assays are particularly amenable for high throughput formats and are particular useful in identifying modulators of a mammalian metabotropic glutamate receptor protein.
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公开(公告)号：EP1129103A1
公开(公告)日：2001-09-05
申请号：EP99964968.4
申请日：1999-11-08
申请人： Merck & Co., Inc.
CPC分类号： C07K14/705 , A61K38/00
摘要： cDNA encoding a novel human G-protein coupled receptor, HG07, as well as the protein encoded by the cDNA, is provided. Methods of identifying agonists and antagonists of HG07 are also provided.
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公开(公告)号：EP1124844A1
公开(公告)日：2001-08-22
申请号：EP99950014.3
申请日：1999-09-29
申请人： MERCK & CO., INC.
IPC分类号： C07K1/00 , C07K4/00 , C07K17/00 , C12N5/02 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74 , C12P21/06 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/705
摘要： cDNA encoding a novel human G-protein coupled receptor, HG52, as well as the protein encoded by the cDNA, is provided. Methods of identifying agonists and antagonists of HG52 are also provided.
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公开(公告)号：EP1276769A1
公开(公告)日：2003-01-22
申请号：EP01934903.4
申请日：2001-04-25
申请人： Merck & Co., Inc.
发明人： LIU, Qingyun , LYNCH, Kevin, R. , HOWARD, Andrew, D. , MELLIN, Theodore, N. , STRACK, Alison , VAN DER PLOEG, Leonardus, H., T. , WANG, Ruiping , JIANG, Qingping , WILLIAMS, David
CPC分类号： C07K14/70571 , C07K14/72 , C07K2319/00 , G01N33/6893 , G01N33/74 , G01N2500/00
摘要： A new neuromedin U receptor, designated NMUR2 has been found, which is involved in modulation of feeding behavior in mammals. Ligands of this receptor are able to modulate eating, and weight gain. Amino acid sequences of the human and rat forms, as well as their nucleic acid sequences are given.
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公开(公告)号：EP1105465A1
公开(公告)日：2001-06-13
申请号：EP99941986.4
申请日：1999-08-02
申请人： MERCK & CO., INC.
CPC分类号： C07K14/705
摘要： cDNA encoding a novel human G-protein coupled receptor, HG03, as well as the protein encoded by the cDNA, is provided. Methods of identifying agonists and antagonists of HG03 are also provided.
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