公开(公告)号：EP1363655A2

公开(公告)日：2003-11-26

申请号：EP01993274.8

申请日：2001-12-14

申请人： Merck & Co., Inc.

发明人： LIU, Qingyun ,  CLEMENTS, Michelle ,  MCDONALD, Terrence, P.

IPC分类号： A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  C07K14/00 ,  C07K14/47 ,  G01N33/53

CPC分类号： G01N33/5091 ,  C07K14/705 ,  C12Q1/6883 ,  C12Q1/6897 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5041 ,  G01N33/566 ,  G01N2333/726

摘要： Disclosed herein are newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polypeptides by recombinant techniques. More particularly, the polynucleotides and polypeptides of the present invention relate to a G-Protein coupled receptor protein, hereinafter referred to as Human GPR54 (GPR54), which happens to be an orphan receptor protein. The invention also relates to inhibiting or activating the action of such polynucleotides and polypeptides.

公开(公告)号：EP1017811A1

公开(公告)日：2000-07-12

申请号：EP98949466.1

申请日：1998-09-24

申请人： MERCK & CO., INC.

发明人： LIU, Qingyun ,  BAILEY, Wendy, J. ,  MCDONALD, Terrence, P.

IPC分类号： C12N15/12 ,  C12N15/63 ,  C12N15/00 ,  C12P21/02 ,  C07K14/47 ,  C07K16/00 ,  G01N33/53 ,  C12Q1/68

CPC分类号： C12N15/8509 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  C07K14/723 ,  C12Q1/68 ,  C12Q1/6876 ,  C12Q1/6897 ,  C12Q2600/158

摘要： This invention provides a novel G-protein coupled glycoprotein hormone receptor HG38, mutant and polymorphic forms of the receptor, nucleic acids encoding the same, expression vectors including the nucleic acids, host cells transformed with nucleic acids, transgenic knockout animals lacking the receptor and transgenic animals expressing a non-native receptor gene, antibodies against the receptor and polypeptides thereof and assays for modulators, agonists and antagonists of the receptor. The receptor proteins and polypeptides, nucleic acids, cells, animals and assays of this invention are useful in drug screening and development, diagnosis and therapeutic applications.

公开(公告)号：EP1012155A1

公开(公告)日：2000-06-28

申请号：EP98923517.1

申请日：1998-05-19

申请人： MERCK & CO., INC.

发明人： LIU, Qingyun ,  CHEN, Fang

IPC分类号： C07H17/00 ,  C12P21/06 ,  C12N1/20 ,  C12N15/00

CPC分类号： C07K14/5759 ,  C07K14/47

摘要： An isolated nucleic acid molecule is disclosed which encodes a novel human uncoupling protein (UCP3), and related recombinant expression vectors, recombinant host cells and substantially purified forms of the UCP3 protein. The isolated nucleic acid and proteins disclosed herein will be useful in methods associated with identifying compounds which modulate energy expenditure and body weight regulation, as well as effecting diseases such as obesity and diabetes as well as mitochondria-associated hypermetabolism. Additionally, the isolated nucleic acids of the present invention are candidates for gene therapy of a mammalian host, including humans.

公开(公告)号：EP1276769A1

公开(公告)日：2003-01-22

申请号：EP01934903.4

申请日：2001-04-25

申请人： Merck & Co., Inc.

发明人： LIU, Qingyun ,  LYNCH, Kevin, R. ,  HOWARD, Andrew, D. ,  MELLIN, Theodore, N. ,  STRACK, Alison ,  VAN DER PLOEG, Leonardus, H., T. ,  WANG, Ruiping ,  JIANG, Qingping ,  WILLIAMS, David

IPC分类号： C07K14/72 ,  C12N15/16

CPC分类号： C07K14/70571 ,  C07K14/72 ,  C07K2319/00 ,  G01N33/6893 ,  G01N33/74 ,  G01N2500/00

摘要： A new neuromedin U receptor, designated NMUR2 has been found, which is involved in modulation of feeding behavior in mammals. Ligands of this receptor are able to modulate eating, and weight gain. Amino acid sequences of the human and rat forms, as well as their nucleic acid sequences are given.

公开(公告)号：EP1105465A1

公开(公告)日：2001-06-13

申请号：EP99941986.4

申请日：1999-08-02

申请人： MERCK & CO., INC.

发明人： LIU, Qingyun ,  McDONALD, Terrence, P. ,  WANG, Ruiping

IPC分类号： C12N5/10 ,  C12N5/16 ,  C12N15/12 ,  C12N15/62 ,  C12N15/63 ,  C12N15/64 ,  C07K14/705

CPC分类号： C07K14/705

摘要： cDNA encoding a novel human G-protein coupled receptor, HG03, as well as the protein encoded by the cDNA, is provided. Methods of identifying agonists and antagonists of HG03 are also provided.

公开(公告)号：EP1097170A1

公开(公告)日：2001-05-09

申请号：EP99934025.0

申请日：1999-07-13

申请人： MERCK & CO., INC.

发明人： LIU, Qingyun ,  HOWARD, Andrew, D. ,  MCKEE, Karen, Kulju

IPC分类号： C07K14/705 ,  C12N15/12 ,  C12N5/10 ,  C12N15/63 ,  G01N33/566 ,  G01N33/50

CPC分类号： C07K14/705 ,  A61K38/00

摘要： This invention relates to a new family of receptors, growth hormone secretagogue-related receptors, which exhibit moderate sequence identity to both the growth hormone secretagogue receptor (GHS-R) and the neurotensin receptor (NT-R). These newly identified receptors are expressed in a diverse set of tissues. This invention also relates to nucleic acids encoding these receptors, and to the use of these receptors to identify ligands that modulate growth hormone release or other endocrine functions.

公开(公告)号：EP0922052A1

公开(公告)日：1999-06-16

申请号：EP97905980.0

申请日：1997-02-18

申请人： MERCK & CO., INC.

发明人： HESS, John, W. ,  CASKEY, C., Thomas ,  LIU, Qingyun ,  PHILLIPS, Michael, S.

IPC分类号： G01N33 ,  C07K14 ,  C12N1 ,  C12N5 ,  C12N15 ,  C12Q1 ,  C12R1

CPC分类号： C07K14/72

摘要： The rat ob receptor gene has been isolated and cloned. Two different alleles have been identified: the wild-type, and the fa-allele which differs from the wild-type by only one base pair. The base pair change, however, introduces an MspI restriction site into the DNA sequence, and also results in an amino acid change. Also part of the invention are the novel receptors, vectors containing the nucleic acid encoding the receptors, host cells transformed with this gene, and assays which use the gene or protein and identify new ligands.

公开(公告)号：EP1233981A1

公开(公告)日：2002-08-28

申请号：EP00978622.9

申请日：2000-11-14

申请人： Merck & Co., Inc. ,  BANYU PHARMACEUTICAL CO., LTD.

发明人： LIU, Qingyun ,  MCDONALD, Terrence, P. ,  HOWARD, Andrew, D. ,  IWAASA, Hisashi ,  SANO, Hideki

IPC分类号： C07K14/05 ,  C07K14/71 ,  C07K16/18 ,  C07K16/22 ,  A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  G01N33/53 ,  G01N33/567 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63 ,  C12N15/64

CPC分类号： C07K14/723 ,  A61K38/00

摘要： The present invention features HG67 nucleic acids and HG67 polypeptides. HG67, also referred to herein as 'MCH-R2', is a G-protein coupled receptor having a high degree of sequence identity with MCH-R1. The amino acid sequence for HG67 is provided by SEQ. ID. NO. 1. The cDNA sequence of HG67 is provided by SEQ. ID. NO. 2.

公开(公告)号：EP1082450A1

公开(公告)日：2001-03-14

申请号：EP99924275.3

申请日：1999-05-17

申请人： MERCK & CO., INC.

发明人： LIU, Qingyun

IPC分类号： C12P21/00 ,  C12N1/21 ,  C12N5/10 ,  C12N15/00 ,  C07H21/04 ,  C07K14/46 ,  A61K39/395 ,  G01N33/00

CPC分类号： C07K14/705

公开(公告)号：EP1017709A1

公开(公告)日：2000-07-12

申请号：EP98951942.6

申请日：1998-09-24

申请人： MERCK & CO., INC.

发明人： LIU, Qingyun ,  ABRAMOVITZ, Mark ,  MCDONALD, Terrence, P. ,  O'NEILL, Gary, P. ,  WANG, Ruiping

IPC分类号： C07H21/04

CPC分类号： G01N33/5091 ,  A01K2217/05 ,  A01K2217/075 ,  C07K14/723 ,  G01N33/5008 ,  G01N33/502 ,  G01N2333/726

摘要： This invention provides a novel G-protein coupled glycoprotein hormone receptor AOMF05, mutant and polymorphic forms of the receptor, nucleic acids encoding the same, expression vectors including the nucleic acids, host cells transformed with nucleic acids, transgenic knockout animals lacking the receptor and transgenic animals expressing a non-native receptor gene, antibodies against the receptor and polypeptides thereof and assays for modulators, agonists and antagonists of the receptor. The receptor proteins and polypeptides, nucleic acids, cells, animals and assays of this invention are useful in drug screening and development, diagnosis and therapeutic applications.