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1.发明公开
公开(公告)号：EP0391594A3
公开(公告)日：1992-01-02
申请号：EP90303300.9
申请日：1990-03-28
申请人： MERCK & CO. INC.
发明人： Gewain, Keith M. , Paress, Philip S. , MacNeil, Douglas J. , Ruby, Carolyn L. , Streicher, Stanley S. , MacNeil, Tanya
CPC分类号： C12N15/10 , C12N9/1007 , C12N9/88 , C12N15/52 , C12N15/76 , C12P17/181 , C12P19/623
摘要： There are disclosed plasmids containing DNA isolated from Streptomyces avermitilis , the microorganism which is used to prepare avermectin compounds, identified as pAT1, pVE650 pVE855, pVE859, pVE1446, pVE923, and pVE924 which contain the genetic information for the biosynthesis of the avermectins. Methods for the isolation of such plasmid and for the manipulation of the plasmids to alter the formation of the avermectin compound are also disclosed.
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2.发明授权Cloning genes from streptomyces avermitilis for avermectin biosynthesis and the methods for their use 失效的链霉菌基因对它们的使用阿维菌素和方法的生物合成克隆。
公开(公告)号：EP0391594B1
公开(公告)日：1995-10-18
申请号：EP90303300.9
申请日：1990-03-28
申请人： Merck & Co., Inc.
发明人： Gewain, Keith M. , Paress, Philip S. , MacNeil, Douglas J. , Ruby, Carolyn L. , Streicher, Stanley S. , MacNeil, Tanya
CPC分类号： C12N15/10 , C12N9/1007 , C12N9/88 , C12N15/52 , C12N15/76 , C12P17/181 , C12P19/623
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3.发明公开Cloning genes from streptomyces avermitilis for avermectin biosynthesis and the methods for their use 失效的链霉菌基因对它们的使用阿维菌素和方法的生物合成克隆。
公开(公告)号：EP0391594A2
公开(公告)日：1990-10-10
申请号：EP90303300.9
申请日：1990-03-28
申请人： MERCK & CO. INC.
发明人： Gewain, Keith M. , Paress, Philip S. , MacNeil, Douglas J. , Ruby, Carolyn L. , Streicher, Stanley S. , MacNeil, Tanya
CPC分类号： C12N15/10 , C12N9/1007 , C12N9/88 , C12N15/52 , C12N15/76 , C12P17/181 , C12P19/623
摘要： There are disclosed plasmids containing DNA isolated from Streptomyces avermitilis , the microorganism which is used to prepare avermectin compounds, identified as pAT1, pVE650 pVE855, pVE859, pVE1446, pVE923, and pVE924 which contain the genetic information for the biosynthesis of the avermectins. Methods for the isolation of such plasmid and for the manipulation of the plasmids to alter the formation of the avermectin compound are also disclosed.
摘要翻译： 有圆盘游离缺失质粒含有来自除虫链霉菌中分离DNA，所述微生物的所有这是用来制备除虫菌素化合物，经鉴定为PAT1，pVE650 pVE855，pVE859，pVE1446，pVE923和pVE924包含用于除虫菌素生物合成的遗传信息。 对于质粒的分离方法并检查质粒的操纵来改变阿维菌素化合物的形成是这样游离缺失盘。
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