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公开(公告)号：EP1012142B1
公开(公告)日：2004-08-11
申请号：EP98942432.0
申请日：1998-09-11
IPC分类号： C07D213/64 , A61K31/44 , C07D213/70 , C07D213/61
CPC分类号： C07D213/64 , C07D213/61 , C07D213/70
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公开(公告)号：EP0912518B1
公开(公告)日：2003-09-10
申请号：EP97929067.3
申请日：1997-07-08
IPC分类号： C07D213/34 , A61K31/44
CPC分类号： C07D213/75 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/80 , C07D213/85 , C07D213/89
摘要： Substituted 3-phenylpyridines of formula (I) and their salts are new. R1 = CH3, NH2, NHC(O)CF3 or NHCH3; Ar = phenyl or pyridinyl (or the N-oxide), (both mono-, di- or trisubstituted by H, halo, 1-6C alkoxy, 1-6C alkylthio, CN, 1-6C alkyl, 1-6C fluoroalkyl, N3, -CO2R3, OH, -C(R4)(R5)-OH, -(1-6C alkyl)CO2R6 or 1-6C fluoroalkoxy); R2 = halo, 1-6C alkoxy, 1-6C alkylthio, CN, 1-6C alkyl, 1-6C fluoroalkyl, N3, -CO2R7, OH, -C(R8)(R9)-OH, -(1-6C alkyl)-CO2R10, 1-6C fluoroalkoxy, NO2, NR11R12 or NHCOR13; R3-R13 = H or 1-6C alkyl; or R4+R5, R8+R9 or R11+R12 complete a saturated monocyclic ring of 3-7 atoms.
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公开(公告)号：EP1458718A1
公开(公告)日：2004-09-22
申请号：EP02784961.1
申请日：2002-12-11
发明人： DUBE, Daniel , DESCHENES, Denis , FORTIN, Rejean , GIRARD, Yves
IPC分类号： C07D471/06 , A61K31/47 , C07D215/22
CPC分类号： C07D215/22 , A61K31/00 , A61K31/47 , A61K31/4706 , A61K31/4745 , C07D215/42 , C07D401/04 , C07D401/10 , C07D401/12 , C07D409/10 , C07D409/12 , C07D471/06
摘要： This invention encompasses a method for treating a prostaglandin E mediated disease or condition comprising administering to a mammalian patient in need of such treatment a compound of Formula (A) in an amount that is effective to treat the prostaglandin E mediated disease or condition.
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4.发明授权
公开(公告)号：EP0889878B1
公开(公告)日：2002-09-04
申请号：EP97908099.1
申请日：1997-03-25
发明人： DUBE, Daniel , FORTIN, Rejean , FRENETTE, Richard , FRIESEN, Richard , GUAY, Daniel , PRESCOTT, Sylvie
IPC分类号： C07C323/22 , C07C317/24 , C07D333/22 , C07D317/72 , C07C311/15 , C07C317/14 , C07C317/44 , C07C317/22 , C07C317/32 , C07D213/30 , C07D339/06
CPC分类号： C07C311/16 , C07C317/14 , C07C317/22 , C07C317/24 , C07C317/32 , C07C317/44 , C07C321/28 , C07C323/22 , C07C323/62 , C07D333/22
摘要： The invention encompasses the novel compound of formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).
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5.发明公开SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS 审中-公开硫取代的芳基二氟甲基膦酸作为PTP-1B抑制剂
公开(公告)号：EP1268494A1
公开(公告)日：2003-01-02
申请号：EP01916791.5
申请日：2001-03-21
发明人： LI, Chun, Sing , LAU, Cheuk, K. , THERIEN, Michel , GAUTHIER, Jacques, Y. , BAYLY, Christopher , DUFRESNE, Claude , FORTIN, Rejean , LEBLANC, Yves , ROY, Patrick , WANG, Zhaoyin
CPC分类号： C07F9/65583 , A61K31/66 , A61K45/06 , C07F9/3882 , C07F9/4056 , C07F9/5537 , C07F9/582 , C07F9/591 , C07F9/60 , C07F9/6506 , C07F9/65068 , C07F9/65122 , C07F9/65128 , C07F9/65182 , C07F9/6524 , C07F9/65312 , C07F9/65318 , C07F9/6539 , C07F9/65395 , C07F9/6552 , C07F9/65522 , A61K2300/00
摘要： The invention encompasses the novel class of compounds represented by formula (I), which are inhibitors of the PTP-1B enzyme . The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes.
摘要翻译： 本发明包括式（I）代表的新型化合物，它们是PTP-1B酶的抑制剂。 本发明还包括治疗或预防PTP-1B介导的疾病（包括糖尿病）的药物组合物和方法。
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公开(公告)号：EP1012142A1
公开(公告)日：2000-06-28
申请号：EP98942432.0
申请日：1998-09-11
IPC分类号： C07D213/64 , A61K31/44 , C07D213/70 , C07D213/61
CPC分类号： C07D213/64 , C07D213/61 , C07D213/70
摘要： The invention encompasses the novel compound of Formula (I) as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula (I). The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula (I).
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