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1.发明公开SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS 审中-公开硫取代的芳基二氟甲基膦酸作为PTP-1B抑制剂
公开(公告)号：EP1268494A1
公开(公告)日：2003-01-02
申请号：EP01916791.5
申请日：2001-03-21
发明人： LI, Chun, Sing , LAU, Cheuk, K. , THERIEN, Michel , GAUTHIER, Jacques, Y. , BAYLY, Christopher , DUFRESNE, Claude , FORTIN, Rejean , LEBLANC, Yves , ROY, Patrick , WANG, Zhaoyin
CPC分类号： C07F9/65583 , A61K31/66 , A61K45/06 , C07F9/3882 , C07F9/4056 , C07F9/5537 , C07F9/582 , C07F9/591 , C07F9/60 , C07F9/6506 , C07F9/65068 , C07F9/65122 , C07F9/65128 , C07F9/65182 , C07F9/6524 , C07F9/65312 , C07F9/65318 , C07F9/6539 , C07F9/65395 , C07F9/6552 , C07F9/65522 , A61K2300/00
摘要： The invention encompasses the novel class of compounds represented by formula (I), which are inhibitors of the PTP-1B enzyme . The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes.
摘要翻译： 本发明包括式（I）代表的新型化合物，它们是PTP-1B酶的抑制剂。 本发明还包括治疗或预防PTP-1B介导的疾病（包括糖尿病）的药物组合物和方法。
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公开(公告)号：EP1115729B1
公开(公告)日：2003-02-19
申请号：EP99944200.7
申请日：1999-09-21
发明人： LEBLANC, Yves , DUFRESNE, Claude , WANG, Zhaoyin , LI, Chun, Sing , GAUTHIER, Jacques, Y. , THERIEN, Michel , LAU, Cheuk, K. , ROY, Patrick
IPC分类号： C07F9/38 , A61K31/66 , C07F9/553 , C07F9/6539 , C07F9/6518 , C07F9/6524 , C07F9/653 , C07F9/6541 , C07F9/6506
CPC分类号： H04M3/42314 , C07F9/3856 , C07F9/386 , C07F9/3865 , C07F9/3869 , C07F9/3882 , C07F9/5537 , C07F9/65068 , C07F9/65188 , C07F9/6524 , C07F9/65318 , C07F9/65324 , C07F9/6539 , C07F9/65395 , C07F9/6541 , H04Q3/625 , H04Q2213/13104 , H04Q2213/13107 , H04Q2213/1322 , H04Q2213/1329 , H04Q2213/13389
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3.发明授权
公开(公告)号：EP0778834B1
公开(公告)日：2000-01-26
申请号：EP95928912.5
申请日：1995-08-24
IPC分类号： C07D333/54 , A61K31/38 , A61K31/44 , C07D307/79 , C07D209/10 , C07D333/56 , C07D495/04 , C07D493/04 , C07D491/04 , C07D409/04 , C07D413/04
CPC分类号： C07D307/79 , C07D209/10 , C07D333/18 , C07D495/04
摘要： The invention encompasses the novel compound of formula (I) as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of formula (I). The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).
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公开(公告)号：EP0975604B1
公开(公告)日：2004-07-21
申请号：EP98910544.0
申请日：1998-03-12
IPC分类号： C07D237/04 , A61K31/50
CPC分类号： C07D401/04 , C07D237/14 , C07D237/16 , C07D401/12 , C07D409/06
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5.发明授权
公开(公告)号：EP0863891B1
公开(公告)日：2002-12-11
申请号：EP96932417.7
申请日：1996-10-09
发明人： BELLEY, Michel , GAUTHIER, Jacques, Y. , GRIMM, Erich , LEBLANC, Yves , LI, Chung-Sing , THERIEN, Michel , BLACK, Cameron , LAU, Cheuk-Kun , PRASIT, Petpiboon , ROY, Patrick
IPC分类号： C07D307/58 , A61K31/365 , A61K31/38 , C07D307/60 , C07D307/62 , C07D307/64 , C07D307/66 , C07D307/68 , C07D307/94 , C07D213/64 , C07C317/24
CPC分类号： C07D405/12 , C07C317/24 , C07C2601/08 , C07D307/58 , C07D307/60 , C07D307/62 , C07D307/64 , C07D307/66 , C07D307/68 , C07D307/83 , C07D307/94 , C07D409/12 , C07D417/12 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
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公开(公告)号：EP1115729A1
公开(公告)日：2001-07-18
申请号：EP99944200.7
申请日：1999-09-21
发明人： LEBLANC, Yves , DUFRESNE, Claude , WANG, Zhaoyin , LI, Chun, Sing , GAUTHIER, Jacques, Y. , THERIEN, Michel , LAU, Cheuk, K. , ROY, Patrick
IPC分类号： C07F9/38 , A61K31/66 , C07F9/553 , C07F9/6539 , C07F9/6518 , C07F9/6524 , C07F9/653 , C07F9/6541 , C07F9/6506
CPC分类号： H04M3/42314 , C07F9/3856 , C07F9/386 , C07F9/3865 , C07F9/3869 , C07F9/3882 , C07F9/5537 , C07F9/65068 , C07F9/65188 , C07F9/6524 , C07F9/65318 , C07F9/65324 , C07F9/6539 , C07F9/65395 , C07F9/6541 , H04Q3/625 , H04Q2213/13104 , H04Q2213/13107 , H04Q2213/1322 , H04Q2213/1329 , H04Q2213/13389
摘要： The invention encompasses the novel class of compounds represented by formula (I) which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases.
摘要翻译： 本发明包括作为PTP-1B酶抑制剂的由式（I）表示的新型化合物。 本发明还包括治疗或预防PTP-1B介导的疾病的药物组合物和方法。
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7.发明授权ARYL SUBSTITUTED 5,5 FUSED AROMATIC NITROGEN COMPOUNDS AS ANTI-INFLAMMATORY AGENTS 失效芳基取代的5,5-连接的芳族硝基化合物用作抗炎活性成分
公开(公告)号：EP0802917B1
公开(公告)日：2001-11-07
申请号：EP96900215.3
申请日：1996-01-10
发明人： GAUTHIER, Jacques, Yves , LAU, Cheuk, K. , LEBLANC, Yves , LI, Chun-Sing , ROY, Patrick , THERIEN, Michel , WANG, Zhaoyin
IPC分类号： C07D513/04 , C07D487/04 , A61K31/425 , A61K31/41
CPC分类号： C07D487/04 , C07D513/04
摘要： The invention encompasses the novel compound of formula (I) as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of formula (I). The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).
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公开(公告)号：EP0975604A1
公开(公告)日：2000-02-02
申请号：EP98910544.0
申请日：1998-03-12
IPC分类号： C07D237/04 , A61K31/50
CPC分类号： C07D401/04 , C07D237/14 , C07D237/16 , C07D401/12 , C07D409/06
摘要： The invention encompasses the pyridazin-3-one compounds of formula (I) as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of formula (I). The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).
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