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公开(公告)号：EP3197452A4
公开(公告)日：2018-02-28
申请号：EP15844485
申请日：2015-09-23
发明人： CAI JIAQIANG , CRESPO ALEJANDRO , DEBENHAM JOHN , DU XIAOXING , LIU PING , LIU RONGQIANG , MADSEN-DUGGAN CRISTINA B , QUAN WEIGUO , SINZ CHRISTOPHER , WANG LIPING
IPC分类号： C07D491/048 , A61K31/4355 , A61P7/06 , C07D495/04
CPC分类号： C07D495/04 , A61P7/06 , C07D491/048
摘要： The present invention concerns compounds of formula I or a pharmaceutically acceptable salt thereof which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
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公开(公告)号：EP2470021A4
公开(公告)日：2013-01-16
申请号：EP10812498
申请日：2010-08-17
申请人： MERCK SHARP & DOHME
发明人： EDMONDSON SCOTT D , BERGER RICHARD , CHANG LEHUA , COLANDREA VINCENT J , HALE JEFFREY J , HARPER BART , KAR NAM FUNG , LI BING , MORRIELLO GREGORI J , MOYES CHRISTOPHER R , SHA DEYOU , SHEN DONG-MING , WANG LIPING , WENDT HARVEY R , ZHU CHENG
CPC分类号： C07D403/14 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/048 , C07D491/107 , C07D491/147 , C07D491/20 , C07D495/10 , C07D495/20 , C07D497/10 , C07D498/04 , C07D513/04 , C07D513/20
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公开(公告)号：EP3197900A4
公开(公告)日：2018-03-21
申请号：EP15843683
申请日：2015-09-23
发明人： CAI JIAQIANG , CRESPO ALEJANDRO , DU XIAOXING , DUBOIS BYRON GABRIEL , GUIADEEN DEODIALSINGH , KOTHANDARAMAN SHANKARAN , LIU PING , LIU RONGQIANG , QUAN WEIGUO , SINZ CHRISTOPHER , WANG LIPING
IPC分类号： C07D471/04 , A61K31/497 , A61P7/06 , C07D471/06 , C07D498/04 , C07D498/06 , C07D498/16 , C07D513/04 , C07D513/06
CPC分类号： C07D513/06 , C07D471/04 , C07D471/06 , C07D498/04 , C07D498/06 , C07D498/16 , C07D513/04
摘要： The present invention concerns compounds of formula I or pharmaceutically acceptable salts thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
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公开(公告)号：EP3197451A4
公开(公告)日：2018-02-28
申请号：EP15843799
申请日：2015-09-23
发明人： CAI JIAQIANG , CRESPO ALEJANDRO , DU XIAOXING , DUBOIS BYRON GABRIEL , LIU PING , LIU RONGQIANG , QUAN WEIGUO , SINZ CHRISTOPHER , WANG LIPING
IPC分类号： C07D491/04 , A61K31/4355 , A61P7/06 , A61P9/10
CPC分类号： C07D491/048 , A61P7/06 , A61P9/10
摘要： The present invention concerns compounds of formula I or pharmaceutically acceptable salts thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
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公开(公告)号：EP2988749A4
公开(公告)日：2017-01-04
申请号：EP14788786
申请日：2014-04-22
申请人： MERCK SHARP & DOHME
发明人： ARRINGTON KENNETH L , DUBOIS BYRON , DEBENHAM JOHN S , LIU PING , NORTHRUP ALAN B , SZEWCZYK JASON W , WANG LIPING , WANG MING
IPC分类号： C07D417/14 , A61K31/497 , A61P29/00 , C07D417/12
CPC分类号： C07D417/14 , A61K31/427 , A61K31/506 , A61K31/5377 , C07D417/12
摘要： The invention provides certain thiazole-substituted aminopyrimidine compounds of the Formula (I) (I), or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R5, R6, and the subscripts r, s, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).
摘要翻译： 本发明提供了式（I）（I）的某些噻唑取代的氨基嘧啶化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 5，R 6和下标r，s和t如本文所定义。 本发明还提供包含这些化合物的药物组合物，以及使用该化合物治疗由脾脏酪氨酸激酶（Syk）介导的疾病或病症的方法。
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6.发明公开THIAZOLE-SUBSTITUTED AMINOHETEROARYLS AS SPLEEN TYROSINE KINASE INHIBITORS 审中-公开噻唑取代的氨基水杨酸作为米氮芥诱导酶抑制剂
公开(公告)号：EP2988744A4
公开(公告)日：2016-11-02
申请号：EP14788026
申请日：2014-04-22
发明人： ANTHONY NEVILLE J , ANDRESEN BRIAN M , NORTHRUP ALAN B , CHILDERS KALEEN K , DONOFRIO ANTHONY , MILLER THOMAS A , LIU YUAN , MACHACEK MICHELLE R , WOO HYUN CHONG , SPENCER KERRIE B , ELLIS JOHN MICHAEL , ALTMAN MICHAEL D , ROMEO ERIC T , GUAY DANIEL , GRIMM JONATHAN , LEBRUN MARIE-EVE , ROBICHAUD JOEL S , WANG LIPING , DUBOIS BYRON , DENG QIAOLIN
IPC分类号： A61K31/44 , A61K31/426 , A61K31/53 , A61P11/00 , A61P19/00 , C07D417/12 , C07D417/14
CPC分类号： C07D417/14 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/53 , C07D417/12
摘要： The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4, and R4 are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).
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公开(公告)号：EP2871957A4
公开(公告)日：2016-01-27
申请号：EP13817154
申请日：2013-07-10
申请人： MERCK SHARP & DOHME
发明人： REGER THOMAS , WALJI ABBAS , SANDERS JOHN , WAI JOHN , WANG LIPING
IPC分类号： C07D487/18 , A61K31/427 , A61K31/513 , A61K31/55 , A61K31/553 , A61K45/06 , C07D498/18 , C07D515/18
CPC分类号： C07D498/18 , A61K31/427 , A61K31/55 , A61K31/553 , A61K45/06 , C07D487/18 , C07D515/18 , A61K31/513 , A61K2300/00
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公开(公告)号：EP3197455A4
公开(公告)日：2018-04-04
申请号：EP15845304
申请日：2015-09-23
发明人： CAI JIAQIANG , COLANDREA VINCENT , CRESPO ALEJANDRO , DEBENHAM JOHN , DU XIAOXING , GUIADEEN DEODIALSINGH , LIU PING , LIU RONGQIANG , MADSEN DUGGAN CRISTINA B , MCCOY JOSHUA G , QUAN WEIGUO , SINZ CHRISTOPHER , WANG LIPING
IPC分类号： C07D215/56 , A61K31/436 , A61P7/06 , C07D221/22 , C07D417/06 , C07D471/04 , C07D491/052
CPC分类号： C07D491/052 , C07D215/56 , C07D221/22 , C07D417/06 , C07D471/04
摘要： The present invention concerns a compound of formula I or a pharmaceutically acceptable salt thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
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9.发明公开SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT 有权取代的环丙基的化合物，其具有这样的化合物和治疗方法的组合物THAT
公开(公告)号：EP2693882A4
公开(公告)日：2014-10-15
申请号：EP12767881
申请日：2012-04-05
申请人： MERCK SHARP & DOHME
发明人： EDMONDSON SCOTT , GUO ZHIQIANG , GEISS WILLIAM B , WOOD HAROLD B , STAMFORD ANDREW W , MILLER MICHAEL W , DEMONG DUANE E , MORRIELLO GREGORI J , ANAND RAJAN , COLANDREA VINCENT J , MACALA MEGAN , MALETIC MILANA , ZHU CHENG , ZHU YUPING , SUN WANYING , ZHAO KAKE , HUANG YONG , HARRIS JOEL M , CHANG LEHUA , KAR NAM FUNG , HU ZHIYONG , WANG LIPING , WANG BOWEI , LIU PING , SZEWCZYK JASON W
IPC分类号： C07D211/22 , A61K31/506 , A61P5/50 , C07D401/12 , C07D405/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04
CPC分类号： C07D513/04 , A61K9/4858 , C07D211/22 , C07D401/12 , C07D405/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04
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