公开(公告)号：EP2178537A4

公开(公告)日：2011-08-17

申请号：EP08780184

申请日：2008-07-15

申请人： MERCK SHARP & DOHME

发明人： DOBBELAAR PETER H ,  DU WU ,  GUO LIANGQIN ,  HAGMANN WILLIAM K ,  HE SHUWEN ,  JIAN TIANYING ,  LIU JIAN ,  NARGUND RAVI P ,  PASTERNAK ALEXANDER ,  SHAH SHRENIK K ,  TRUONG QUANG T ,  YE ZHIXIONG ,  DELLUREFICIO JAMES ,  BAKSHI RAMAN

IPC分类号： A61K31/535 ,  A61K31/437 ,  A61P3/10

CPC分类号： C07D471/04

公开(公告)号：EP2523558A4

公开(公告)日：2013-06-19

申请号：EP11733256

申请日：2011-01-11

申请人： MERCK SHARP & DOHME

发明人： GUO LIANGQIN ,  HAGMANN WILLIAM K ,  HE SHUWEN ,  LAI ZHONG ,  LIU JIAN ,  NARGUND RAVI P ,  SHAH SHRENIK K ,  TRUONG QUANG T

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P3/10

CPC分类号： C07D471/04

公开(公告)号：EP3148996A4

公开(公告)日：2018-01-17

申请号：EP15803641

申请日：2015-05-28

申请人： MERCK SHARP & DOHME

发明人： WALSH SHAWN P ,  CUMMING JARED N ,  HE SHUWEN ,  TAOKA BRANDON M ,  TRUONG QUANG T ,  WU WEN-LIAN

IPC分类号： C07D471/04 ,  A61K31/541 ,  A61P3/10 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  C07D487/04

CPC分类号： C07D487/04 ,  C07D471/04

摘要： In its many embodiments, the present invention provides certain C2-carbocyclic iminothiazine dioxide compounds, including compounds Formula (I); or a tautomers thereof, and pharmaceutically acceptable salts of said compounds and said tautomers, wherein R1, R2, ring A, RA, m, ring B, RB, n, ring C, RC and p are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed.