公开(公告)号：EP3229801A4

公开(公告)日：2018-07-18

申请号：EP15866965

申请日：2015-12-07

申请人： MERCK SHARP & DOHME ,  MOCHIDA PHARM CO LTD

发明人： ZHANG TING ,  CHEN YI-HENG ,  GUO LIANGQIN ,  HRUZA ALAN ,  JIAN TIANYING ,  LI BING ,  MENG DONGFANG ,  PARKER DANN L JR ,  SHERER EDWARD C ,  WOOD HAROLD B ,  SAKURADA ISAO

IPC分类号： A61K31/4184 ,  C07D235/04

CPC分类号： C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04

摘要： The present invention provides a compound of Formula I, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.

公开(公告)号：EP2178537A4

公开(公告)日：2011-08-17

申请号：EP08780184

申请日：2008-07-15

申请人： MERCK SHARP & DOHME

发明人： DOBBELAAR PETER H ,  DU WU ,  GUO LIANGQIN ,  HAGMANN WILLIAM K ,  HE SHUWEN ,  JIAN TIANYING ,  LIU JIAN ,  NARGUND RAVI P ,  PASTERNAK ALEXANDER ,  SHAH SHRENIK K ,  TRUONG QUANG T ,  YE ZHIXIONG ,  DELLUREFICIO JAMES ,  BAKSHI RAMAN

IPC分类号： A61K31/535 ,  A61K31/437 ,  A61P3/10

CPC分类号： C07D471/04