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公开(公告)号：EP2706852A4
公开(公告)日：2014-11-05
申请号：EP12782391
申请日：2012-05-04
发明人： DESCHENES DENIS , ALTMAN MICHAEL D , ELLIS JOHN MICHAEL , FISCHER CHRISTIAN , HAIDLE ANDREW M , KATTAR SOLOMON D , NORTHRUP ALAN B , SCHELL ADAM J , SMITH GRAHAM F , TAOKA BRANDON M , BIENSTOCK COREY , DI FRANCESCO MARIA EMILIA , DONOFRIO ANTHONY , PETERSON SCOTT , SPENCER KERRIE B , JEWELL JAMES PATRICK , ALI AMJAD , BENNETT DAVID JONATHAN , DANG QUN , WAL JOHN
IPC分类号： A01N43/40 , A61K31/44 , C07D213/04
CPC分类号： C07D401/14 , C07D401/12 , C07D409/14 , C07D417/14 , C07D471/04
摘要： The present invention provides novel pyrimidine amines of formula I which are potent inhibitors of spleen tyrosine kinase, or are prodrugs thereof, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis and cancer.
摘要翻译： 本发明提供了式I的新型嘧啶胺，其是脾脏酪氨酸激酶的有效抑制剂，或其前药，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD和类风湿性关节炎和癌症。
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公开(公告)号：EP2200612A4
公开(公告)日：2011-06-22
申请号：EP08831197
申请日：2008-09-08
申请人： MERCK SHARP & DOHME
发明人： SIU TONY , YOUNG JONATHAN , ALTMAN MICHAEL , NORTHRUP ALAN , KATCHER MATTHEW , SATHYAJITH ELLALAHEWAGE , KOZINA EKATERINA , PETERSON SCOTT , CHILDERS MATTHEW
IPC分类号： A61K31/495 , A61P35/00 , C07D471/04 , C07D471/14
CPC分类号： C07D471/04 , C07D471/14
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3.发明公开CYCLOALKYLNITRILE PYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS 有权CYCLOALKYLNITRILPYRAZOLCARBOXAMIDAS JANUS KINASEINHIBITORS
公开(公告)号：EP2758377A4
公开(公告)日：2015-05-13
申请号：EP12833410
申请日：2012-09-21
申请人： MERCK SHARP & DOHME
发明人： BRUBAKER JASON , DINSMORE CHRISTOPHER J , HOFFMAN DAWN MARIE , JUNG JOON , LIU DUAN , PETERSON SCOTT , SIU TONY , TORRES LUIS E , ZHANG HONGJUN , WEI ZHONGYONG , SHI FENG
IPC分类号： C07D231/10 , A61K31/415 , A61P35/00 , A61P37/00
CPC分类号： C07D405/08 , C07D231/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/14
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4.发明公开
公开(公告)号：EP2758051A4
公开(公告)日：2015-03-18
申请号：EP12834379
申请日：2012-09-21
申请人： MERCK SHARP & DOHME
发明人： BRUBAKER JASON , CHILDERS MATTHEW LLOYD , CHRISTOPHER MATTHEW , CLOSE JOSHUA T , KATZ JASON DAVID , JUNG JOON , PETERSON SCOTT , SILIPHAIVANH PHIENG , SIU TONY , SMITH GRAHAM FRANK , TORRES LUIS E , WOO HYUN CHONG , YOUNG JONATHAN R , ZHANG HONGJUN
IPC分类号： C07D401/14 , A61K31/415 , A61P11/06 , C07D231/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/08 , C07D405/04 , C07D405/06 , C07D405/08 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/14
CPC分类号： C07D405/08 , C07D231/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
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