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1.发明公开NOVEL CYCLIC AZABENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS 审中-公开用于抗糖尿病药物的新型环状亚苄基咪唑衍生物
公开(公告)号：EP3243385A1
公开(公告)日：2017-11-15
申请号：EP17173914.7
申请日：2012-02-23
发明人： ANAND, Rajan , APGAR, James, M. , BIFTU, Tesfaye , CHEN, Ping , CHU, Lin , COLANDREA, Vincent, J. , DONG, Guizhen , DROPINSKI, James, F. , FENG, Danqing , HICKS, Jacqueline, D. , JIANG, Jinlong , KIM, Alexander, J. , LEAVITT, Kenneth, J. , LI, Bing , QIAN, Xiaoxia , SEBHAT, Iyassu , WEI, Lan , WILKENING, Robert, R. , WU, Zhicai
IPC分类号： A01N43/58
CPC分类号： A61K31/5377 , A61K31/351 , A61K31/366 , A61K31/397 , A61K31/437 , A61K31/4412 , A61K31/496 , A61K31/4985 , A61K31/519 , A61K45/06 , C07D471/04 , C07D519/00 , A61K2300/00
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译： 结构式（I）的新型化合物是AMP-蛋白激酶的激活剂并且可用于治疗，预防和抑制由AMPK-活化的蛋白激酶介导的疾病。 本发明化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖症，高胆固醇血症和高血压。
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公开(公告)号：EP3978479A1
公开(公告)日：2022-04-06
申请号：EP21204099.2
申请日：2017-03-20
发明人： CROWLEY, Brendan, M. , CAMPBELL, Brian, T. , DUFFY, Joseph, L. , GRESHOCK, Thomas, J. , GUIADEEN, Deodial, G. , HARVEY, Andrew, John , HUFF, Belinda, C. , LEAVITT, Kenneth, J. , RADA, Vanessa, L. , SANDERS, John, M. , SHIPE, William, D. , SUEN, Linda, M. , BELL, Ian, M.
IPC分类号： C07D231/12 , C07D233/64 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/04 , C07D249/06 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D495/04 , C07D277/26 , C07D285/08 , C07D285/12
摘要： The present disclosure relates to compounds of formula I that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation
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公开(公告)号：EP3962483A1
公开(公告)日：2022-03-09
申请号：EP20798030.1
申请日：2020-04-27
发明人： BELL, Ian, M. , CAMPBELL, Brian, T. , CROWLEY, Brendan, M. , FELLS, James , LEAVITT, Kenneth, J. , ROECKER, Anthony, J. , HARVEY, Andrew John , HUFF, Belinda, C. , PAUL, Dharam , MORICE, Christophe , JOSEPH, Christophe , BAZZINI, Patrick , CONTRERAS, Jean-Marie , GARRIDO, Fabrice , WITZEL, Aurelie
IPC分类号： A61K31/438 , A61K31/64 , C07D221/20 , C07D401/02
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4.发明公开
公开(公告)号：EP3534888A1
公开(公告)日：2019-09-11
申请号：EP17866851.3
申请日：2017-10-30
发明人： CROWLEY, Brendan, M. , BELL, Ian, M. , HARVEY, Andrew John , SHIPE, William, D. , LEAVITT, Kenneth, J. , SANDERS, John, M. , GUIADEEN, Deodial, G. , SUEN, Linda, M. , GRESHOCK, Thomas, J. , RADA, Vanessa, L.
IPC分类号： A61K31/18 , C07C311/08
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公开(公告)号：EP2888007A1
公开(公告)日：2015-07-01
申请号：EP13830944.8
申请日：2013-08-15
发明人： APGAR, James, M. , BIFTU, Tesfaye , CHEN, Ping , FENG, Danqing , HICKS, Jacqueline, D. , KEKEC, Ahmet , LEAVITT, Kenneth, J. , LI, Bing , SEBHAT, Iyassu , QIAN, Xiaoxia , WEI, Lan , WILKENING, Robert, R. , WU, Zhicai
IPC分类号： A61P3/10 , A61K31/4184 , A61K31/415 , A61K31/454
CPC分类号： C07D417/14 , A61K31/366 , A61K31/397 , A61K31/4184 , A61K31/4192 , A61K31/4196 , A61K31/427 , A61K31/4985 , A61K31/506 , A61K31/5377 , C07D405/12 , C07D405/14 , C07D413/14
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译： 结构式（I）的新型化合物是AMP-蛋白激酶的激活剂，并且可用于治疗，预防和抑制由AMPK-活化的蛋白激酶介导的疾病。 本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖症，高胆固醇血症和高血压。
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公开(公告)号：EP2888008B1
公开(公告)日：2018-12-26
申请号：EP13831336.6
申请日：2013-08-19
发明人： APGAR, James, M. , BIFTU, Tesfaye , CHEN, Ping , FENG, Danqing , HICKS, Jacqueline, D. , KEKEC, Ahmet , LEAVITT, Kenneth, J. , LI, Bing , SEBHAT, Iyassu , QIAN, Xiaoxia , WEI, Lan , WILKENING, Robert, R. , WU, Zhicai , ARASAPPAN, Ashok
IPC分类号： C07D471/04 , C07D519/00 , A61P3/10 , A61K31/4184 , A61K31/415 , A61K31/454
CPC分类号： C07D471/04 , A61K31/19 , A61K31/366 , A61K31/397 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/4985 , A61K31/5377 , C07C53/18 , C07D519/00 , A61K2300/00
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
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7.发明授权
公开(公告)号：EP2677869B1
公开(公告)日：2017-11-08
申请号：EP12749051.4
申请日：2012-02-23
发明人： ANAND, Rajan , APGAR, James, M. , BIFTU, Tesfaye , CHEN, Ping , CHU, Lin , COLANDREA, Vincent, J. , DONG, Guizhen , DROPINSKI, James, F. , FENG, Danqing , HICKS, Jacqueline, D. , JIANG, Jinlong , KIM, Alexander, J. , LEAVITT, Kenneth, J. , LI, Bing , QIAN, Xiaoxia , SEBHAT, Iyassu , WEI, Lan , WILKENING, Robert, R. , WU, Zhicai
IPC分类号： A01N43/58
CPC分类号： A61K31/5377 , A61K31/351 , A61K31/366 , A61K31/397 , A61K31/437 , A61K31/4412 , A61K31/496 , A61K31/4985 , A61K31/519 , A61K45/06 , C07D471/04 , C07D519/00 , A61K2300/00
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公开(公告)号：EP2906040A1
公开(公告)日：2015-08-19
申请号：EP13831487.7
申请日：2013-08-15
发明人： APGAR, James, M. , BIFTU, Tesfaye , CHEN, Ping , FENG, Danqing , HICKS, Jacqueline, D. , KEKEC, Ahmet , LEAVITT, Kenneth, J. , LI, Bing , SEBHAT, Iyassu , QIAN, Xiaoxia , WEI, Lan , WILKENING, Robert, R. , WU, Zhicai
IPC分类号： A01N43/50 , A61K31/4184
CPC分类号： C07D417/14 , A61K31/4184 , A61K31/4196 , A61K31/427 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/12 , C07D405/14 , C07D413/14
摘要： Novel compounds described herein are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPKactivated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译： 本文所述的新化合物是AMP-蛋白激酶的激活剂，并且可用于治疗，预防和抑制由AMPK激活的蛋白激酶介导的疾病。 本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖症，高胆固醇血症和高血压。
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9.发明公开NOVEL AZABENZIMIDAZOLE TETRAHYDROFURAN DERIVATIVES 有权NEUARTIGE AZABENZIMIDAZOL TETRAHYDROFURANDERIVATE
公开(公告)号：EP2888008A1
公开(公告)日：2015-07-01
申请号：EP13831336.6
申请日：2013-08-19
发明人： APGAR, James, M. , BIFTU, Tesfaye , CHEN, Ping , FENG, Danqing , HICKS, Jacqueline, D. , KEKEC, Ahmet , LEAVITT, Kenneth, J. , LI, Bing , SEBHAT, Iyassu , QIAN, Xiaoxia , WEI, Lan , WILKENING, Robert, R. , WU, Zhicai , ARASAPPAN, Ashok
IPC分类号： A61P3/10 , A61K31/4184 , A61K31/415 , A61K31/454
CPC分类号： C07D471/04 , A61K31/19 , A61K31/366 , A61K31/397 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/4985 , A61K31/5377 , C07C53/18 , C07D519/00 , A61K2300/00
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
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10.发明公开NOVEL CYCLIC AZABENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS 有权诺伊尔CYCLISCHE AZABENZIMIDAZOLDERIVATE ALS ANTIDIABETIKA
公开(公告)号：EP2677869A1
公开(公告)日：2014-01-01
申请号：EP12749051.4
申请日：2012-02-23
发明人： ANAND, Rajan , APGAR, James, M. , BIFTU, Tesfaye , CHEN, Ping , CHU, Lin , COLANDREA, Vincent, J. , DONG, Guizhen , DROPINSKI, James, F. , FENG, Danqing , HICKS, Jacqueline, D. , JIANG, Jinlong , KIM, Alexander, J. , LEAVITT, Kenneth, J. , LI, Bing , QIAN, Xiaoxia , SEBHAT, Iyassu , WEI, Lan , WILKENING, Robert, R. , WU, Zhicai
IPC分类号： A01N43/58
CPC分类号： A61K31/5377 , A61K31/351 , A61K31/366 , A61K31/397 , A61K31/437 , A61K31/4412 , A61K31/496 , A61K31/4985 , A61K31/519 , A61K45/06 , C07D471/04 , C07D519/00 , A61K2300/00
摘要： Novel compounds of structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
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