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公开(公告)号：EP2411001A1
公开(公告)日：2012-02-01
申请号：EP10756588.9
申请日：2010-03-15
发明人： BURGEY, Christopher, S. , CROWLEY, Brendan, M. , DENG, Zhengwu, J. , PAONE, Daniel, V. , POTTEIGER, Craig, M.
IPC分类号： A61K31/16 , A61K31/405 , A61K31/415
CPC分类号： C07D401/12 , A61K31/16 , A61K31/405 , A61K31/415 , A61K45/06 , C07D413/12 , C07D413/14 , C07D495/04 , A61K2300/00
摘要： The subject invention relates to novel P2X
3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or tissue injury pain that can be treated using a P2X
3 receptor subunit modulator.摘要翻译： 本发明涉及新型P2X 3受体拮抗剂，其在治疗与疼痛相关的疾病状态中发挥关键作用，所述疾病状态特别是可用P2X 3受体亚单位调节剂治疗的周围疼痛，炎性疼痛或组织损伤疼痛。
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公开(公告)号：EP3788043A1
公开(公告)日：2021-03-10
申请号：EP19722488.4
申请日：2019-04-29
发明人： CROWLEY, Brendan, M. , CAMPBELL, Brian, T. , CHOBANIAN, Harry, R. , FELLS, James, I. , GUIADEEN, Deodial, G. , GRESHOCK, Thomas, J. , LEAVITT, Kenneth, J. , RADA, Vanessa, L. , BELL, Ian, M.
IPC分类号： C07D413/14 , C07D413/04 , C07D417/04 , C07D417/14 , A61P25/00 , A61K31/438 , C07D401/04 , C07D471/04 , C07D471/08 , C07D487/04 , C07D513/04 , A61K31/439 , A61K31/444 , A61K31/501 , A61K31/506
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3.发明公开
公开(公告)号：EP3534889A1
公开(公告)日：2019-09-11
申请号：EP17868282.9
申请日：2017-10-30
发明人： CROWLEY, Brendan, M. , BELL, Ian, M. , HARVEY, Andrew John , CAMPBELL, Brian, T. , GRESHOCK, Thomas, J. , RADA, Vanessa, L.
IPC分类号： A61K31/18 , C07C311/08
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公开(公告)号：EP3433234A1
公开(公告)日：2019-01-30
申请号：EP17714623.0
申请日：2017-03-20
发明人： CROWLEY, Brendan, M. , CAMPBELL, Brian, T. , DUFFY, Joseph, L. , GRESHOCK, Thomas, J. , GUIADEEN, Deodial, G. , HARVEY, Andrew John , HUFF, Belinda, C. , LEAVITT, Kenneth, J. , RADA, Vanessa, L. , SANDERS, John, M. , SHIPE, William, D. , SUEN, Linda, M. , BELL, Ian, M.
IPC分类号： C07D231/12 , C07D233/64 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/04 , C07D249/06 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D495/04 , C07D277/26 , C07D285/08 , C07D285/12
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公开(公告)号：EP2411001B1
公开(公告)日：2018-01-17
申请号：EP10756588.9
申请日：2010-03-15
发明人： BURGEY, Christopher, S. , CROWLEY, Brendan, M. , DENG, Zhengwu, J. , PAONE, Daniel, V. , POTTEIGER, Craig, M.
IPC分类号： A61K31/16 , A61K31/405 , A61K31/415 , C07D401/12 , C07D413/12 , C07D413/14 , C07D495/04 , A61K45/06
CPC分类号： C07D401/12 , A61K31/16 , A61K31/405 , A61K31/415 , A61K45/06 , C07D413/12 , C07D413/14 , C07D495/04 , A61K2300/00
摘要： The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or tissue injury pain that can be treated using a P2X3 receptor subunit modulator.
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公开(公告)号：EP4054569A1
公开(公告)日：2022-09-14
申请号：EP20886145.0
申请日：2020-10-29
IPC分类号： A61K31/438 , A61K31/439 , A61K31/444
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公开(公告)号：EP3978479A1
公开(公告)日：2022-04-06
申请号：EP21204099.2
申请日：2017-03-20
发明人： CROWLEY, Brendan, M. , CAMPBELL, Brian, T. , DUFFY, Joseph, L. , GRESHOCK, Thomas, J. , GUIADEEN, Deodial, G. , HARVEY, Andrew, John , HUFF, Belinda, C. , LEAVITT, Kenneth, J. , RADA, Vanessa, L. , SANDERS, John, M. , SHIPE, William, D. , SUEN, Linda, M. , BELL, Ian, M.
IPC分类号： C07D231/12 , C07D233/64 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/04 , C07D249/06 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D495/04 , C07D277/26 , C07D285/08 , C07D285/12
摘要： The present disclosure relates to compounds of formula I that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation
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公开(公告)号：EP3962483A1
公开(公告)日：2022-03-09
申请号：EP20798030.1
申请日：2020-04-27
发明人： BELL, Ian, M. , CAMPBELL, Brian, T. , CROWLEY, Brendan, M. , FELLS, James , LEAVITT, Kenneth, J. , ROECKER, Anthony, J. , HARVEY, Andrew John , HUFF, Belinda, C. , PAUL, Dharam , MORICE, Christophe , JOSEPH, Christophe , BAZZINI, Patrick , CONTRERAS, Jean-Marie , GARRIDO, Fabrice , WITZEL, Aurelie
IPC分类号： A61K31/438 , A61K31/64 , C07D221/20 , C07D401/02
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公开(公告)号：EP3684357A1
公开(公告)日：2020-07-29
申请号：EP18859614.2
申请日：2018-09-14
IPC分类号： A61K31/4245 , C07C311/16 , C07D213/04 , C07D213/24 , C07D213/44
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10.发明公开
公开(公告)号：EP3534888A1
公开(公告)日：2019-09-11
申请号：EP17866851.3
申请日：2017-10-30
发明人： CROWLEY, Brendan, M. , BELL, Ian, M. , HARVEY, Andrew John , SHIPE, William, D. , LEAVITT, Kenneth, J. , SANDERS, John, M. , GUIADEEN, Deodial, G. , SUEN, Linda, M. , GRESHOCK, Thomas, J. , RADA, Vanessa, L.
IPC分类号： A61K31/18 , C07C311/08
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