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公开(公告)号：EP1094837B1
公开(公告)日：2009-12-23
申请号：EP99932831.3
申请日：1999-06-28
发明人： ALLAN, Gordon, Moore , MEEHAN, Brian, Martin , ELLIS, John, Albert , KRAKOWKA, George, Steven , AUDONNET, Jean-Christophe, Francis , MCNEILLY, Francis
IPC分类号： A61K39/395 , C07K14/01 , C12N7/00 , C12N15/86
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/5252 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2750/10022 , C12N2750/10034 , C12N2750/14322 , C12N2750/14334 , Y10S424/815 , Y10S435/81
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公开(公告)号：EP1094837A2
公开(公告)日：2001-05-02
申请号：EP99932831.3
申请日：1999-06-28
发明人： ALLAN, Gordon, Moore , MEEHAN, Brian, Martin , ELLIS, John, Albert , KRAKOWKA, George, Steven , AUDONNET, Jean-Christophe, Francis , MCNEILLY, Francis
IPC分类号： A61K39/395 , C07K14/01 , C12N7/00 , C12N15/86
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/5252 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2750/10022 , C12N2750/10034 , C12N2750/14322 , C12N2750/14334 , Y10S424/815 , Y10S435/81
摘要： The invention relates to antigenic preparations and vaccines directed against the porcine multisystemic wasting syndrome (PMWS), comprising at least one porcine circovirus antigen, preferably type II, and at least one porcine parvovirus antigen.
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公开(公告)号：EP1246920B1
公开(公告)日：2011-10-05
申请号：EP00960628.6
申请日：2000-08-28
发明人： ELLIS, John Albert , ALLAN, Gordon, Moore , MEEHAN, Brian , CLARK, Edward , HAINES, Deborah , HASSARD, Lori , HARDING, John , CHARREYRE, Catherine, Elisabeth , CHAPPUIS, Gilles, Emile , KRAKOWKA, George, Steve , AUDONNET, Jean-Christophe, Francis , MCNEILLY, Francis
CPC分类号： C07K14/005 , A61K2039/53 , C12N7/00 , C12N15/86 , C12N2710/24043 , C12N2750/10022
摘要： Porcine circovirus-2 (PCV-2) is a recently identified agent wherein the potential spectrum of PCV-2-associated disease has been expanded by evidence of vertical and sexual transmission and associated reproductive failure in swine populations. PCV-2 was isolated from a litter of aborted piglets from a farm experiencing late term abortions and stillbirths. Severe, diffuse myocarditis was present in one piglet associated with extensive immunohistochemical staining for PCV-2 antigen. Variable amounts of PCV-2 antigen were also present in liver, lung and kidney of multiple fetuses. Inoculation of female pigs with a composition including an immunogen from PCV-2 or an epitope of interest from such an immunogen or with a vector expressing such an immunogen or epitope of interest prior to breeding, such as within the first five weeks of life, or prior to the perinatal period, or repeatedly over a lifetime, or during pregnancy, such as between the 6th and 8th and/or the 10th and 13th weeks of gestation, can prevent myocarditis, abortion and intrauterine infection associated with porcine circovirus-2. In addition, innoculation of male and/or female pigs with the aforementioned compositions can be carried out to prevent transmission of PCV-2 from male to female (or vice versa) during mating. Thus, the invention involves methods and compositions for preventing myocarditis, abortion and intrauterine infection associated with porcine circovirus-2.
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公开(公告)号：EP1246920A2
公开(公告)日：2002-10-09
申请号：EP00960628.6
申请日：2000-08-28
发明人： ELLIS, John Albert , ALLAN, Gordon, Moore , MEEHAN, Brian , CLARK, Edward , HAINES, Deborah , HASSARD, Lori , HARDING, John , CHARREYRE, Catherine, Elisabeth , CHAPPUIS, Gilles, Emile , KRAKOWKA, George, Steve , AUDONNET, Jean-Christophe, Francis , MCNEILLY, Francis
CPC分类号： C07K14/005 , A61K2039/53 , C12N7/00 , C12N15/86 , C12N2710/24043 , C12N2750/10022
摘要： Porcine circovirus-2 (PCV-2) is a recently identified agent wherein the potential spectrum of PCV-2-associated disease has been expanded by evidence of vertical and sexual transmission and associated reproductive failure in swine populations. PCV-2 was isolated from a litter of aborted piglets from a farm experiencing late term abortions and stillbirths. Severe, diffuse myocarditis was present in one piglet associated with extensive immunohistochemical staining for PCV-2 antigen. Variable amounts of PCV-2 antigen were also present in liver, lung and kidney of multiple fetuses. Inoculation of female pigs with a composition including an immunogen from PCV-2 or an epitope of interest from such an immunogen or with a vector expressing such an immunogen or epitope of interest prior to breeding, such as within the first five weeks of life, or prior to the perinatal period, or repeatedly over a lifetime, or during pregnancy, such as between the 6th and 8th and/or the 10th and 13th weeks of gestation, can prevent myocarditis, abortion and intrauterine infection associated with porcine circovirus-2. In addition, innoculation of male and/or female pigs with the aforementioned compositions can be carried out to prevent transmission of PCV-2 from male to female (or vice versa) during mating. Thus, the invention involves methods and compositions for preventing myocarditis, abortion and intrauterine infection associated with porcine circovirus-2.
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公开(公告)号：EP1185662B1
公开(公告)日：2011-03-02
申请号：EP00940474.0
申请日：2000-06-08
申请人： MERIAL
IPC分类号： A61K39/175 , C12N15/38 , C12N15/27 , A61K48/00
CPC分类号： A61K39/265 , A61K39/12 , A61K39/155 , A61K39/175 , A61K39/245 , A61K39/27 , A61K2039/525 , A61K2039/53 , A61K2039/552 , A61K2039/70 , C07K14/535 , C07K2319/02 , C12N2710/16634 , C12N2710/16734 , C12N2760/18334 , C12N2760/18434 , C12N2760/18634
摘要： The invention aims at improving the efficacy and protection induced by DNA vaccination against viruses of the family of Paramyxoviridae and against the herpes virus, in pets and sport animals. The improvement of DNA vaccination is achieved either by formulating the vaccine with a cationic lipid containing a quaternary ammonium salt, DMRIE, or by modifications in the nucleotide sequence coding for the antigen of interest in particular of deletions of the fragment of the nucleotide sequence coding for the transmembrane domain of the antigen of interest, and/or insertions of introns and/or insertions of nucleotide sequences coding for the signal peptides, or by adding GM-CSF, or by combinations thereof. The invention also concerns the resulting vaccines.
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6.发明公开VACCINATION OR IMMUNIZATION USING A PRIME-BOOST REGIMEN AGAINST BRSV, BHV-1, BVDV, BPI-3 有权疫苗和免疫AGAINST BRSV，BHV-1，BVDV，BPI-3由一原BOOST方法中使用
公开(公告)号：EP1594537A1
公开(公告)日：2005-11-16
申请号：EP03815962.0
申请日：2003-02-19
申请人： MERIAL
IPC分类号： A61K39/12 , A61K39/245 , A61K39/155 , C12N15/09 , C12N15/33 , C12N15/38 , C12N15/40 , C12N15/45 , A61P11/00
CPC分类号： A61K39/12 , A61K39/155 , A61K39/245 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/552 , A61K2039/55572 , C12N2710/16734 , C12N2710/24043 , C12N2760/18534 , C12N2770/24334
摘要： Disclosed and claimed are methods and compositions and kits for the vaccination or immunization of an animal, such as a mammal, advantageously a bovine, involving a prime-boost regimen.
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公开(公告)号：EP1377660A2
公开(公告)日：2004-01-07
申请号：EP02759818.4
申请日：2002-04-05
申请人： MERIAL
IPC分类号： C12N1/00
CPC分类号： C12N15/86 , A61K39/12 , A61K2039/5256 , A61K2039/53 , A61K2039/552 , A61K2039/55511 , A61K2039/55522 , A61K2039/55555 , C07K14/005 , C07K2319/02 , C12N2710/24043 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171
摘要： The invention concerns in vivo and in vitro expression vectors comprising a polynucleotide coding for the structural protein E of the Nile fever virus or the WN virus, optionally associated with a polynucleotide coding for the pre-membrane protein prM and/or for the membrane protein M, in particular in the form coding for prM-M-E. Said in vivo expression vectors are incorporated in live vaccines. The in vivo expression vectors are used for producing in vitro proteins which can then be used in subunit vaccines. The invention also concerns multivalent vaccines comprising a vaccine constituent against the WN virus and a vaccine constituent against another pathogen. The invention is particular designed for horses, dogs, cats, cattle, pigs and birds.
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公开(公告)号：EP1058558A1
公开(公告)日：2000-12-13
申请号：EP99937879.7
申请日：1999-03-01
申请人： MERIAL
CPC分类号： A61K39/39 , A61K48/00 , A61K2039/53 , A61K2039/55555
摘要： The invention concerns a recombinant live vaccine comprising a viral vector incorporating and expressing in vivo a heterologous nucleotide sequence, preferably a pathogenic agent gene, and at least a adjuvant compound selected among the acrylic or methacrylic polymers and the maleic anhydride and alkenyl derivative copolymers. It concerns in particular an acrylic and methacrylic acid polymer cross-linked with a sugar or polyalcohol polyalkenyl ether (carbomer), in particular crosslinked with a saccharose allyl or with allylpentaerythritol. It can also be a maleic anhydride and crosslinked ethylene copolymer, for example divinylether.
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公开(公告)号：EP1248650B1
公开(公告)日：2006-11-29
申请号：EP01907651.2
申请日：2001-01-19
申请人： MERIAL
CPC分类号： A61K47/24 , A61K9/0019 , A61K39/39 , A61K47/186 , A61K2039/53 , A61K2039/55511
摘要： The invention concerns a DNA vaccine against a pathogen affecting production-type animals, in particular cattle and swine, comprising a plasmid containing a nucleotide sequence coding for an immunogen of a pathogen of the animal species concerned, in conditions enabling the expression in vivo of said sequence, and a cationic lipid containing a quaternary ammonium salt, of formula (I) wherein: R1 is a linear aliphatic radical, saturated or unsaturated, having 12 to 18 carbon atoms; R2 is another aliphatic radical, containing 2 or 3 carbon atoms; and X is a hydroxyl or amine group, said lipid being preferably DMRIE.
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10.发明授权
公开(公告)号：EP1058558B1
公开(公告)日：2005-01-26
申请号：EP99937879.7
申请日：1999-03-01
申请人： MERIAL
CPC分类号： A61K39/39 , A61K48/00 , A61K2039/53 , A61K2039/55555
摘要： The invention concerns a recombinant live vaccine comprising a viral vector incorporating and expressing in vivo a heterologous nucleotide sequence, preferably a pathogenic agent gene, and at least a adjuvant compound selected among the acrylic or methacrylic polymers and the maleic anhydride and alkenyl derivative copolymers. It concerns in particular an acrylic and methacrylic acid polymer cross-linked with a sugar or polyalcohol polyalkenyl ether (carbomer), in particular crosslinked with a saccharose allyl or with allylpentaerythritol. It can also be a maleic anhydride and crosslinked ethylene copolymer, for example divinylether.
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