公开(公告)号：EP0153641A3

公开(公告)日：1986-07-30

申请号：EP85101412

申请日：1985-02-11

申请人： MILES LABORATORIES, INC.

发明人： Gantzer, Mary Lou ,  Hemmes, Paul R. Jr. ,  Wong, Daniel

IPC分类号： G01N31/22 ,  G01N33/52 ,  G01N33/84 ,  C07C119/00

CPC分类号： G01N33/84 ,  G01N33/521

摘要： The present invention resides in the discovery of a new test means for detecting the presence of an ion in an aqueous test sample and determining its concentration. The test means comprises a porous carrier matrix substantially uniformly incorporated with a) a homogeneous hydrophobic mixture containing three principal ingredients: an ionophore capable of forming a complex with the ion, a hydrophobic vehicle, and a reporter substance capable of interacting with the complex of ionophore and ion to produce a detectable response; and b) a buffering substance capable of providing a pH In the range of from about 5 to 10. A test device comprises the test means affixed to one upper flat face of an elongated support member. In use, the aqueous test sample is contacted with the test means or device. The presence and/or concentration of the ion in the test sample is then determined by observing any detectable response produced. The test means and device of the present invention provide rapid results, sufficient detectable response forming In most instances in at least a few minutes.

公开(公告)号：EP0121192A3

公开(公告)日：1988-01-13

申请号：EP84103212

申请日：1984-03-23

申请人： MILES LABORATORIES, INC.

发明人： Gantzer, Mary Lou

IPC分类号： C12Q01/28 ,  G01N33/52

CPC分类号： C12Q1/28 ,  G01N33/725 ,  Y10S436/904

摘要： A test composition, device and method for determining a peroxidatively active substance in a test sample, as well as a method for preparing the device, are disclosed. The composition comprises an organic hydroperoxide and an indicator capable of providing a detectable response in the presence of the organic hydroperoxide and peroxidatively active substance, wherein the organic hydroperoxide is a substituted cumene hydroperoxide having the formula:
in which any one of the X substituents is lower alkyl of from 1 to 6 carbon atoms, Cl, Br, l, NO 2 or carboxyl; or any two ofthe X substituents, same or different, are lower alkyl of from 1 to 6 carbon atoms, Cl, Br, l. NO 2 or carboxyl. The device comprises a carrier matrix incorporated with the composition, and the method comprises contacting a test sample with the device and observing a detectable response in the device. A method for preparing the device comprises preparing a solution of the composition, wetting the carrier matrix therewith and drying the wetted matrix.

公开(公告)号：EP0130520B1

公开(公告)日：1986-09-24

申请号：EP84107255.6

申请日：1984-06-25

申请人： MILES LABORATORIES, INC.

发明人： Gantzer, Mary Lou

IPC分类号： C12Q1/28 ,  G01N33/52

CPC分类号： C12Q1/28 ,  C12Q2326/12 ,  Y10S436/904

公开(公告)号：EP0130520A1

公开(公告)日：1985-01-09

申请号：EP84107255.6

申请日：1984-06-25

申请人： MILES LABORATORIES, INC.

发明人： Gantzer, Mary Lou

IPC分类号： C12Q1/28 ,  G01N33/52

CPC分类号： C12Q1/28 ,  C12Q2326/12 ,  Y10S436/904

摘要： A test composition, device and method for determining a peroxidatively active substance in a test sample, as well as a method for preparing and using the device, are disclosed. The composition comprises an organic hydroperoxide, an indicator capable of providing a detectable response in the presence of the organic hydroperoxide and a peroxidatively active substance, and, as a stabilizing agent, an aniline having the formula: and in which either X 1 or X 2 is hydrogen, NH 2 , N0 2 or NO, the other of X 1 or X 2 being hydrogen. The device comprises a carrier matrix incorporated with the composition, and the method for using the device comprises contacting a test sample with the device and observing a detectable response therein. A method for preparing the device comprises preparing two or more solutions of the ingredients of the composition, wetting the carrier matrix sequentially therewith and drying the matrix after each wetting.
in which R 1 and R 2 , same or different, are hydrogen, lower alkyl of from 1 to 6 carbon atoms, phenyl, a-naphthyl or β-naphthyl;

公开(公告)号：EP0121191A2

公开(公告)日：1984-10-10

申请号：EP84103211.3

申请日：1984-03-23

申请人： MILES LABORATORIES, INC.

发明人： Gantzer, Mary Lou

IPC分类号： C12Q1/28 ,  G01N33/52

CPC分类号： C12Q1/28

摘要： Atest composition, device and method for determining a peroxidatively active substance in a test sample, as well as a method for preparing the device, are disclosed. The composition comprises an organic hydroperoxide and an indicator capable of providing a detectable response in the presence of the organic hydroperoxide and peroxidatively active substance, wherein the organic hydroperoxide is tetralin hydroperoxide. The device comprises a carrier matrix incorporated with the composition, and the method comprises contacting a test sample with the device and observing a detectable response in the device. A method for preparing the device comprises preparing a solution of the composition ingredients, wetting the carrier matrix therewith and drying the wetted matrix.

摘要翻译： 测试组合物，设备和方法用于确定性采矿一个测试样品中的peroxidatively活性物质，以及制备该装置的方法，是游离缺失盘。 上能够提供在有机氢过氧化物和peroxidatively活性物质的存在的可检测响应，worin有机氢过氧化物的有机指示剂的氢过氧化物和该组合物包括四氢化萘是氢过氧化物。 该装置包括与所述组合物结合的载体基质，以及该方法包括使与所述设备的测试样品，并观察在该装置可检测的响应。 一种制备该装置的方法包括制备该组合物的成分的溶液中，用有润湿载体基质和润湿的基质干燥。