公开(公告)号：EP0819180B1

公开(公告)日：2006-12-20

申请号：EP96911596.3

申请日：1996-04-05

申请人： LifeScan, Inc.

发明人： GALEN, Robert S. ,  BURD, John, F. ,  HOBLITZELL, Talei ,  NEYER, Gebhard

IPC分类号： C12Q1/34 ,  C12Q1/54 ,  C12M1/00 ,  G01N21/76 ,  G01N21/77 ,  G01N31/00 ,  G01N31/22 ,  G01N33/64 ,  G01N33/66

CPC分类号： C12Q1/34 ,  C12Q1/54 ,  C12Q2326/12 ,  C12Q2326/14 ,  C12Q2326/92 ,  G01N21/645 ,  G01N33/526 ,  G01N33/66 ,  G01N2333/42 ,  Y10S435/97 ,  Y10S436/828 ,  Y10T436/144444

摘要： The present invention is directed to a single test system and method for determining the integrated glycemic condition of a subject by measuring the concentration of glucose and the level of protein-bound glucose in a subject's body fluid, such as whole blood. The glucose concentration is indicative of the subject's immediate glycemic condition, whereas the protein-bound glucose concentration is indicative of either intermediate or long-term glycemic condition. Optionally, other analytes indicative of glycemie condition, such as ketone bodies or fatty acid derivatives, can also be measured. The present invention also provides a method of diagnosing diabetes. The invention additionally provides a method for analyzing the concentration of fructosamine in less than or equal to five minutes without the use of a reaction accelerator.

公开(公告)号：EP1234050A2

公开(公告)日：2002-08-28

申请号：EP00985017.3

申请日：2000-11-13

申请人： MERCK PATENT GmbH

发明人： TANZER, Dieter ,  KRENN, Karl-Dieter

IPC分类号： C12Q1/28

CPC分类号： C12Q1/28 ,  C12Q2326/12

摘要： The invention relates to an agent and a method for the dry chemical detection of lactoperoxidase in milk or dairy products. The method according to the invention is characterized by rapid execution thereof and said method has a high degree of sensitivity. The high detection sensitivity is achieved by adding iodide ions to the usual reagents.

公开(公告)号：EP0918881A1

公开(公告)日：1999-06-02

申请号：EP97929680.0

申请日：1997-05-15

申请人： Mercury Diagnostics Inc.

发明人： PRIEST, John, Hedger ,  NELSON, Eric, Michael

IPC分类号： C12Q1

CPC分类号： C12Q1/54 ,  C12Q1/28 ,  C12Q2326/12 ,  C12Q2326/14 ,  C12Q2326/96 ,  Y10S435/97

摘要： A dry reagent test strip for determining the concentration of an analyte in a liquid sample is described. The test strip has a matrix containing reagent detection chemistry, which includes an oxidase enzyme that can utilize the analyte as a substrate forming hydrogen peroxide, a benzidine dye precursor, a peroxidase enzyme, and an antipyrine compound. The addition of an antipyrine compound to the reagent detection chemistry provides a standard concentration graph which is substantially linear in a desired range of analyte concentration. The precision and accuracy of reading the test strip are enhanced.

摘要翻译： 描述了用于确定液体样品中分析物浓度的干试剂测试条。 测试条具有含试剂检测化学试剂的基质，其包含可利用分析物作为形成过氧化氢的底物的氧化酶，联苯胺染料前体，过氧化物酶和安替比林化合物。 向试剂检测化学品添加安替比林化合物提供了标准浓度图，其在分析物浓度的期望范围内基本上是线性的。 读取测试条的精度和准确性得到增强。

公开(公告)号：EP0597410B1

公开(公告)日：1999-02-24

申请号：EP93118036.8

申请日：1993-11-07

申请人： KYOTO DAIICHI KAGAKU CO., LTD.

发明人： Yagi, Yuji, c/o Kyoto Daiichi Kagaku Co. Ltd. ,  Kagawa, Tamaki, c/o Kyoto Daiichi Kagaku Co. Ltd. ,  Tamura, Hiroshi, c/o Kyoto Daiichi Kagaku Co. Ltd. ,  Ota, Tetsuya, c/o Kyoto Daiichi Kagaku Co. Ltd.

IPC分类号： C12Q1/26 ,  C12Q1/28 ,  G01N33/72 ,  G01N33/82

CPC分类号： G01N33/82 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q2326/12 ,  G01N33/725 ,  Y10T436/144444 ,  Y10T436/25125

公开(公告)号：EP0563114B1

公开(公告)日：1997-11-05

申请号：EP92901013.0

申请日：1991-12-13

申请人： BRITISH TECHNOLOGY GROUP LIMITED

发明人： DAVIES, Michael Jonathan ,  RICE-EVANS, Catherine, Anne

IPC分类号： G01N33/68 ,  C12Q1/26 ,  C12Q1/28

CPC分类号： C12Q1/26 ,  C12Q1/28 ,  C12Q2326/12 ,  C12Q2326/30 ,  G01N33/6887 ,  G01N2333/805 ,  G01N2800/324

摘要： A diagnostic test can determine the occurrence of myocardial infarction or the total plasma antioxidant status as a marker of predisposition to such an event, or the antioxidant status of other clinical an non-clinical samples. The test involves contacting a clinical sample in the presence of myoglobin and an oxidant therefor with a compoud which reacts in that environment to form a chromogenic species with a characteristic absorption band in the visible spectrum spaced from potentially interfering bands attributable to haem proteins and other blood components.

公开(公告)号：EP0123902B1

公开(公告)日：1991-09-18

申请号：EP84103368.1

申请日：1984-03-27

申请人： Byk-Sangtec Diagnostica GmbH & Co. KG

发明人： Lentfer, Dierck, Dr.

IPC分类号： C12Q1/28

CPC分类号： C12Q1/28 ,  C12Q2326/12

公开(公告)号：EP0207936A4

公开(公告)日：1989-04-24

申请号：EP85900888

申请日：1985-01-17

申请人： HYGEIA SCIENCES LTD

发明人： GERBER BEGO ,  BLOCK ELLIOTT ,  BAHAR IZAK ,  CANTAROW WALTER D ,  EATON CHERYL ,  JONES WENDY E ,  COSEO MARY ,  BRUINS JOHN B

IPC分类号： G01N33/543 ,  C12Q1/26 ,  C12Q1/28 ,  G01N33/535 ,  G01N33/569 ,  G01N33/58 ,  G01N33/74 ,  G01N33/76 ,  G01N33/54

CPC分类号： C12Q1/28 ,  C12Q2326/12 ,  G01N33/56911 ,  G01N33/76 ,  Y10S435/81 ,  Y10S435/962 ,  Y10S435/964 ,  Y10S436/817 ,  Y10S436/818

摘要： Colorimetric detection of bindable substances such as antibodies and antigens using chromogens of improved sensitivity and stability. The chromogenes take the form of activated solutions containing tetramethylbenzidine or water soluble derivatives of tetramethylbenzidine. Such chromogens are of particular use in home testing applications for detection of antigens such as human chorionic gonadotropin, human luteinizing hormone, and gonococcus bacteria, as well as the detection of antibodies for these substances.

公开(公告)号：EP0222700A1

公开(公告)日：1987-05-20

申请号：EP86810483.7

申请日：1986-10-28

申请人： WARNER-LAMBERT COMPANY

发明人： Talmage, Joseph M.

IPC分类号： G01N33/72

CPC分类号： C12Q1/28 ,  C12Q2326/12 ,  Y10S436/904

摘要： The invention provides a reagent composition for detecting peroxidase-like activity in aqueous media, particularly for determining occult blood in fecal matter "in-the-bowl". The reagents comprise a dry mixture of a 3, 3', 5, 5' tetramethylbenzidine and an alkali metal perborate, such as sodium perborate, and preferably also including a strong organic carboxylic acid such as citric acid and a sequesterant for trace metals such as ethylenediaminetetraacetic acid. The composition can be made increasingly more stable by coating the tetramethylbenzidine and an antioxidant with a water soluble polymer and or film coating the sodium perborate with a coating at least partially soluble in water. The reagents are deposited in porous or holed matrices including adsorbent paper, gelatin and molded polysaccharide film.

公开(公告)号：EP0214262A1

公开(公告)日：1987-03-18

申请号：EP86901925.0

申请日：1986-03-07

申请人： BOOTS-CELLTECH DIAGNOSTICS LIMITED

发明人： WEAVERS, Elizabeth, Anne 66 Chiltern Street ,  POWELL, Michael, Joseph 5 War Admiral Court

IPC分类号： C12N9 ,  C12Q1 ,  G01N33

CPC分类号： C12N9/0065 ,  C12N9/96 ,  C12Q1/28 ,  C12Q2326/12 ,  G01N33/535 ,  G01N2400/18 ,  Y10S435/975

摘要： Réactifs améliorés à substrat de tétraméthylbenzidine peroxydase et contenant une peroxydase. Le réactif contenant la peroxydase consiste en une solution aqueuse tamponnée comprenant une peroxydase, telle qu'une peroxydase de raifort, ou un conjugué de peroxydase, et un substrat spécifique de la peroxydase, tel que la tétraméthybenzidine, en l'absence de peroxyde. Le conjugué de peroxydase est avantageusement un conjugué d'une peroxydase et un composant spécifique de liaison d'une analyse. Le réactif à substrat de tétraméthylbenzine peroxydase comprend de la tétraméthylbenzidine et une BETA-cyclodextrine en solution aqueuse. La solution peut contenir également un peroxyde. Un de ces réactifs améliorés ou les deux peuvent être inclus dans un kit de réactifs d'analyse.

公开(公告)号：EP0072450B1

公开(公告)日：1986-09-17

申请号：EP82106522.4

申请日：1982-07-20

申请人： MILES LABORATORIES, INC.

发明人： Tyhach, Richard J.

IPC分类号： C12Q1/54 ,  C12Q1/28

CPC分类号： C12Q1/54 ,  C12Q1/28 ,  C12Q2326/12