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公开(公告)号：EP0958356A4
公开(公告)日：2008-03-05
申请号：EP97954803
申请日：1997-12-30
申请人： MIRUS BIO CORP
发明人： WOLFF JON A , HAGSTROM JAMES E , BUDKER VLADIMIR G , TRUBETSKOY VLADIMER S , SLATTUM PAUL M , HANSON LISA J
CPC分类号： C12N15/87 , A61K47/59 , A61K47/60 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0025 , A61K48/0041
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公开(公告)号：EP1585560A4
公开(公告)日：2011-03-16
申请号：EP03772025
申请日：2003-07-28
申请人： MIRUS BIO CORP
发明人： WOLFF JON A , BUDKER VLADIMIR G , HERWEIJER HANS , HAGSTROM JAMES E , MONAHAN SEAN D , HEGGE JULIA , SUBBOTIN VLADIMIR
IPC分类号： A61K9/00 , A01N37/18 , A01N43/04 , A61K31/70 , A61K38/00 , A61K48/00 , A61M20060101 , A61M1/00
CPC分类号： A61K9/0019 , A61K38/00 , A61K48/0075 , C12N15/87 , C12N2799/022
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公开(公告)号：EP1651239A4
公开(公告)日：2006-12-20
申请号：EP03814414
申请日：2003-07-22
申请人： MIRUS BIO CORP
发明人： WOLFF JON A , HAGSTROM JAMES E , BUDKER VLADIMIR G , ROZEMA DAVID B , MONAHAN SEAN D , SLATTUM PAUL M
IPC分类号： A61K48/00 , A61K31/70 , C12N15/113
CPC分类号： C12N15/113 , A61K31/70 , A61K48/0025 , A61K48/0041 , A61K48/0075 , A61K48/0083 , C12N2320/32 , A61K2300/00
摘要： Disclosed is a process for transfecting genetic material into a mammalian cell to alter endogenous properties of the cell. The process comprises designing a polynucleotide for transfection. Then the polynucleotide is inserted into a mammalian vessel such as a tail vein or artery. Prior to insertion, subsequent to insertion, or concurrent with insertion the permeability of the vessel is increased thereby the genetic material is delivered to the parenchymal cell altering endogenous properties of the cell.
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公开(公告)号：EP1626755A4
公开(公告)日：2008-01-23
申请号：EP04753760
申请日：2004-05-28
申请人： MIRUS BIO CORP
发明人： HAGSTROM JAMES E , HERWEIJER HANS , HEGGE JULIA
CPC分类号： A61K48/0083 , A61K48/0075
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公开(公告)号：EP1691609A4
公开(公告)日：2006-11-29
申请号：EP04709076
申请日：2004-02-06
申请人： MIRUS BIO CORP
CPC分类号： A61K48/0075 , A61K48/0083
摘要： A process for delivering a polynucleotide into a parenchymal cell in a mammal, comprising, transporting the polynucleotide into a vessel communicating with the parenchymal cell in tissue or organ of the mammal such that the polynucleotide is transfected into the parenchymal cell. More specifically, the polynucleotide consists of a viral vector.
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公开(公告)号：EP1646282A4
公开(公告)日：2006-10-11
申请号：EP04779025
申请日：2004-07-17
申请人： MIRUS BIO CORP
发明人： HERWEIJER HANS , BATES MARY KAY , WOLFF JON A , BUDKER VLADIMIR G , HAGSTROM JAMES E , MONAHAN SEAN D , SLATTUM PAUL M , ROZEMA DAVID B
IPC分类号： A01N43/04 , A01N59/16 , A01N59/26 , A61K31/70 , A61K39/00 , A61K39/29 , A61K47/48 , A61K48/00 , C07H21/00 , C07K14/135 , C07K14/47 , C07K14/475 , C07K14/73 , C07K16/00 , C07K16/18 , C12N5/00 , C12N5/02 , C12N5/16 , C12N9/02 , C12N15/113 , C12N15/63 , C12N15/85
CPC分类号： C07K16/18 , A01N59/16 , A01N59/26 , A61K31/70 , A61K39/00 , A61K39/0011 , A61K47/58 , A61K47/59 , A61K47/62 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0075 , A61K2039/53 , C07H21/00 , C07K14/005 , C07K14/4708 , C07K14/475 , C07K14/70514 , C07K16/00 , C12N9/0069 , C12N15/113 , C12N15/87 , C12N2320/32 , C12N2760/18522 , A01N2300/00 , A61K2300/00
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7.发明公开INHIBITION OF GENE FUNCTION BY DELIVERY OF POLYNUCLEOTIDE-BASED GENE EXPRESSION INHIBITORS TO MAMMALIAN CELLS IN VIVO 审中-公开按分布基因表达的基因功能的抑制的抑制剂基于体内多核苷酸SAUGE动物细胞
公开(公告)号：EP1636385A4
公开(公告)日：2010-06-02
申请号：EP04776998
申请日：2004-06-24
申请人： MIRUS BIO CORP
发明人： LEWIS DAVID L , SPENCER ANDREW G , WOLFF JON A , HAGSTROM JAMES E , HERWEIJER HANS , LOOMIS AARON G
IPC分类号： C12Q1/68 , A01N43/04 , A61K20060101 , A61K31/07 , C07H21/04 , C12N15/11 , C12N15/113
CPC分类号： A61K31/07 , C07K14/005 , C12N15/111 , C12N15/1131 , C12N15/1137 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/3233 , C12N2320/31 , C12N2320/32 , C12N2730/10122 , C12Y101/01034 , C12Y206/01002
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8.发明公开COMPOSTIONS AND PROCESSES USING SIRNA AMPHIPATHIC COMPOUNDS AND POLYCATIONS 审中-公开组合物或 使用方法SIRNA两性聚阳离子和连接的
公开(公告)号：EP1679964A4
公开(公告)日：2009-06-24
申请号：EP03814415
申请日：2003-08-11
申请人： MIRUS BIO CORP
发明人： LEWIS DAVID L , HAGSTROM JAMES E , HERWEIJER HANS , MONAHAN SEAN D , WOLF JON A , SLATTUM PAUL M
CPC分类号： C12N15/111 , A61K31/58 , A61K31/74 , C12N15/88 , C12N2310/14 , C12N2320/32 , A61K2300/00
摘要： Described is a composition with low toxicity comprising an amphipathic compound and a polycation, useful for delivering siRNA to a cell. The composition may be used in the process of delivering a siRNA to an animal cell, or more particularly a mammal cell, in a multi-well format.
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9.发明公开EXPRESSION OF ZETA NEGATIVE AND ZETA POSITIVE NUCLEIC ACIDS USING A DYSTROPHIN GENE 审中-公开作者ZETA阴性和ZETA-正用核酸抗肌萎缩蛋白表达GEN
公开(公告)号：EP1581053A4
公开(公告)日：2007-02-21
申请号：EP03743756
申请日：2003-01-24
申请人： MIRUS BIO CORP
发明人： MONAHAN SEAN D , WOLFF JON A , SLATTUM PAUL M , HAGSTROM JAMES E , BUDKER VLADIMIR G , DAVID B ROZEMA
CPC分类号： A61K48/0016 , A61K48/0041 , A61K48/0075 , A61K48/0083
摘要： Disclosed is expression of zeta negative and zeta positive nucleic acids or nucleic acid complexes using a dystrophin gene in a process for providing nucleic acid expression in a striated (skeletal or cardiac) muscle cell for the purpose of providing a change to the endogenous properties of the cell for cells affected by muscular dystrophy.
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10.发明公开INTRAVASCULAR DELIVERY OF NON-VIRAL NUCLEIC ACID 审中-公开INTRAVASKULÄREABGABE EINER NICHTVIRALENNUCLEINSÄURE
公开(公告)号：EP1660099A4
公开(公告)日：2007-01-03
申请号：EP03778146
申请日：2003-11-05
申请人： MIRUS BIO CORP
发明人： WOLFF JON A , HAGSTROM JAMES E , BUDKER VLADIMIR G , ROZEMA DAVID B , MONAHAN SEAN D , SLATTUM PAUL M
CPC分类号： A61K48/005 , A61K31/7088 , A61K38/1808 , A61K38/1825 , A61K47/59 , A61K47/62 , A61K47/645 , A61K48/0008 , A61K48/0016 , A61K48/0025 , A61K48/0041 , A61K48/0075 , A61K48/0083 , C07H21/00 , A61K2300/00
摘要： Disclosed is a process for delivering genetic material into a mammalian cell to alter endogenous properties of the cell. The process comprises designing a polynucleotide for transfection. Then the polynucleotide is inserted into a mammalian vessel such as an artery. Prior to insertion, subsequent to insertion, or concurrent with insertion the permeability of the vessel is increased thereby the genetic material is delivered to the parenchymal cell altering endogenous properties of the cell.
摘要翻译： 公开了将遗传物质递送到哺乳动物细胞中以改变细胞的内源性质的方法。 该过程包括设计用于转染的多核苷酸。 然后将多核苷酸插入哺乳动物血管例如动脉中。 在插入之前，插入之后或与插入同时，血管的渗透性增加，由此将遗传物质递送至实质细胞，从而改变细胞的内源性质。
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