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公开(公告)号：EP2539468A4
公开(公告)日：2013-08-28
申请号：EP11748075
申请日：2011-02-24
发明人： ABKEVICH VICTOR , TIMMS KIRSTEN , GUTIN ALEXANDER
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/156 , G06F19/18 , G06F19/20 , G06F19/22 , G06F19/24 , G06F19/34
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公开(公告)号：EP2794907A4
公开(公告)日：2015-08-26
申请号：EP12860530
申请日：2012-12-21
CPC分类号： C12Q1/6886 , A61K31/282 , A61K33/24 , C12Q2600/106 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158
摘要： This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.
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公开(公告)号：EP2981624A4
公开(公告)日：2016-11-30
申请号：EP14779403
申请日：2014-04-04
发明人： ABKEVICH VICTOR , TIMMS KIRSTEN , GUTIN ALEXANDER
CPC分类号： C12Q1/6886 , A61K33/24 , C12Q1/6827 , C12Q1/6858 , C12Q2600/106 , C12Q2600/154 , C12Q2600/156 , G06F19/18 , C12Q2535/122 , C12Q2537/143
摘要： This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of homologous recombination deficiency (HRD) or an HRD signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an HRD signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.
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4.发明公开METHODS AND MATERIALS FOR ASSESSING LOSS OF HETEROZYGOSITY 有权VERFAHREN UND MATERIALIEN ZUR BEWERTUNG DES VERLUSTS DER HETEROZYGOTIE
公开(公告)号：EP2582847A4
公开(公告)日：2013-12-18
申请号：EP11796544
申请日：2011-06-17
CPC分类号： C12Q1/6886 , C12Q1/6827 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G06F19/18 , C12Q2537/16
摘要： This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.
摘要翻译： 该文件提供了评估样品（例如癌细胞）中存在杂合性缺失（LOH）特征的方法和材料。 例如，提供了用于确定细胞（例如癌细胞）是否包含LOH标签的方法和材料。 还提供了用于鉴定具有同源性定向修复缺陷（HDR）的细胞（例如癌细胞）的材料和方法，以及用于鉴定可能对特定癌症治疗方案有反应的癌症患者的材料和方法。
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公开(公告)号：EP2721181A4
公开(公告)日：2014-12-31
申请号：EP12801070
申请日：2012-06-15
发明人： GUTIN ALEXANDER , TIMMS KIRSTEN , LANCHBURY JERRY
CPC分类号： C12Q1/6827 , C12Q1/6858 , C12Q1/6874 , C12Q1/6883 , G06F19/22 , C12Q2535/122 , C12Q2537/143
摘要： Methods and systems for detecting allelic imbalance using nucleic acid sequencing are provided.
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公开(公告)号：EP2611941A4
公开(公告)日：2014-01-22
申请号：EP11822498
申请日：2011-08-30
发明人： STONE STEVEN , GUTIN ALEXANDER , WAGNER SUSANNE , REID JULIA
IPC分类号： C12Q1/68 , C12N15/11 , G01N33/574 , G06F19/10
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G06F19/20
摘要： Biomarkers and methods using the biomarkers for molecular detection and classification of disease and, particularly, molecular markers for cancer diagnosis and prognosis and methods of use thereof are provided.
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公开(公告)号：EP2591126A4
公开(公告)日：2014-01-01
申请号：EP11804357
申请日：2011-07-07
发明人： STONE STEVE , GUTIN ALEXANDER , WAGNER SUSANNE , REID JULIA
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158
摘要： Biomarkers and methods using the biomarkers for the prediction of the recurrence risk of cancer in a patient are provided.
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公开(公告)号：EP2958999A4
公开(公告)日：2016-10-19
申请号：EP14754889
申请日：2014-02-21
发明人： WAGNER SUSANNE , STONE STEVEN , GUTIN ALEXANDER , REID JULIA
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
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9.发明公开GENE SIGNATURES FOR LUNG CANCER PROGNOSIS AND THERAPY SELECTION 审中-公开GENSIGNATURENFÜRLUNGENKREBSPROGNOSE UNDERAPIEAUSWAHL
公开(公告)号：EP2744919A4
公开(公告)日：2015-04-08
申请号：EP12825690
申请日：2012-08-17
发明人： WAGNER SUSANNE , STONE STEVEN , GUTIN ALEXANDER , REID JULIA
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： The invention provides for molecular classification of disease and, particularly, molecular markers for lung cancer prognosis and therapy selection and methods and systems of use thereof.
摘要翻译： 本发明提供疾病的分子分类，特别是用于肺癌预后和治疗选择的分子标志物及其使用方法和系统。
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10.发明公开GENES AND GENE SIGNATURES FOR DIAGNOSIS AND TREATMENT OF MELANOMA 审中-公开GENE UND GENSIGNATUREN ZUR DIAGNOSE UND BEHANDLUNG VON MELANOMEN
公开(公告)号：EP2971156A4
公开(公告)日：2017-02-08
申请号：EP14769159
申请日：2014-03-12
申请人： MYRIAD GENETICS INC , WARF BRYAN , ROA BENJAMIN , GUTIN ALEXANDER , FLAKE DARL
发明人： WARF BRYAN , ROA BENJAMIN , GUTIN ALEXANDER , FLAKE DARL
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： Panels of biomarkers, methods and systems are disclosed for determining gene expression, and diagnosing and treating melanoma.
摘要翻译： 公开了用于确定基因表达以及诊断和治疗黑素瘤的生物标志物，方法和系统的组。
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