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公开(公告)号：EP3784317A1
公开(公告)日：2021-03-03
申请号：EP19791709.9
申请日：2019-04-24
申请人： MannKind Corporation
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2.发明授权
公开(公告)号：EP2637657B1
公开(公告)日：2019-05-22
申请号：EP11788696.0
申请日：2011-11-09
申请人： MannKind Corporation
发明人： LEONE-BAY, Andrea , STOWELL, Grayson, W. , GUARNERI, Joseph, J. , CARLSON, Dawn, M. , GRANT, Marshall , SMUTNEY, Chad, C.
IPC分类号： A61K31/4045 , A61K31/4196 , A61P25/06
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公开(公告)号：EP2872205B1
公开(公告)日：2017-02-08
申请号：EP13742558.3
申请日：2013-07-12
申请人： MannKind Corporation
CPC分类号： A61M15/00 , A61M11/001 , A61M15/0005 , A61M15/002 , A61M15/0021 , A61M15/0025 , A61M15/0028 , A61M15/0065 , A61M2016/0027 , A61M2202/064 , A61M2205/076 , A61M2206/14 , A61M2206/16 , A61M2206/20
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4.发明公开DRY POWDER DRUG DELIVERY SYSTEM AND METHODS 审中-公开系统在VERFAHREN ZUR VERABREICHUNG VON ARZNEIMITTELN在TROCKENPULVERFORM
公开(公告)号：EP2582421A1
公开(公告)日：2013-04-24
申请号：EP11727905.9
申请日：2011-06-21
申请人： MannKind Corporation
发明人： SMUTNEY, Chad, C. , ADAMO, Benoit , POLIDORO, John, M. , KINSEY, P., Spencer , OVERFIELD, Dennis , SAHI, Carl , BILLINGS, Christine , MARINO, Mark, T.
IPC分类号： A61M15/00
CPC分类号： A61M15/0091 , A61M11/06 , A61M15/0021 , A61M15/0025 , A61M15/0028 , A61M15/0043 , A61M2202/064 , A61M2205/6045 , A61M2205/6081
摘要： A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, endocrine disease such as diabetes and/or obesity.
摘要翻译： 公开了一种肺部药物递送系统，包括呼吸驱动的干粉吸入器和用于递送干粉制剂的药筒。 吸入器和药筒可以具有药物递送制剂，其包含例如二酮哌嗪和活性成分，包括小有机分子，肽和蛋白质，包括用于治疗疾病和病症的胰岛素和胰高血糖素样肽1 ，例如内分泌疾病如糖尿病和/或肥胖症。
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5.发明公开INHALER ADAPTOR FOR A LASER DIFFRACTION APPARATUS AND METHOD FOR MEASURING PARTICLE SIZE DISTRIBUTION 有权吸入设备适配器用于测量粒度的激光衍射装置和方法
公开(公告)号：EP2408499A1
公开(公告)日：2012-01-25
申请号：EP10710519.9
申请日：2010-03-18
申请人： MannKind Corporation
发明人： ADAMO, Benoit , SHAH, Saiyam , SMUTNEY, Chad, C.
IPC分类号： A61M15/00
CPC分类号： G01N15/0205 , A61M11/001 , A61M15/00 , A61M15/0065 , A61M2202/064 , A61M2209/02 , G01N15/0211 , G01N15/06 , G01N2015/025
摘要： The present disclosure relates to an improved device (10) and methods for adapting to a laser diffraction apparatus (20) used for measuring particle size distribution and density of the plume of a powder composition emitted from a dry powder inhaler (30).
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公开(公告)号：EP2403490A2
公开(公告)日：2012-01-11
申请号：EP10706467.7
申请日：2010-03-04
申请人： MannKind Corporation
发明人： SMUTNEY, Chad, C. , ADAMO, Benoit , POLIDORO, John, M. , KINSEY, P., Spencer , OVERFIELD, Dennis , SAHI, Carl, R. , BILLINGS, Christine , MARINO, Mark, T.
IPC分类号： A61K9/72
CPC分类号： A61K38/29 , A61K31/495 , A61K38/1816 , A61K38/193 , A61K38/28 , A61M15/0021 , A61M15/0028 , A61M15/0035 , A61M2202/064
摘要： A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of endocrine disease, for example, diabetes and/or obesity.
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公开(公告)号：EP2254629A1
公开(公告)日：2010-12-01
申请号：EP09724539.3
申请日：2009-03-27
申请人： MannKind Corporation
发明人： SMUTNEY, Chad, C. , KINSEY, P., Spencer , POLIDORO, John, M. , SAHI, Carl, R. , ADAMO, Benoit , MCLEAN, Scott , OVERFIELD, Dennis , BRYANT, Anthony
IPC分类号： A61M15/00
CPC分类号： A61M15/0023 , A61M15/0015 , A61M15/002 , A61M15/0028 , A61M15/0043 , A61M2016/0021 , A61M2016/0027 , A61M2202/064 , A61M2202/07 , A61M2205/58 , A61M2205/581 , A61M2205/582
摘要： Dry powder inhaler systems for pulmonary delivery of pharmaceuticals are disclosed. The dry powder inhalation systems comprise a dry powder inhalation device or inhaler ( 109) and a cartridge (1600) containing a pharmaceutical formulation comprising an active ingredient for delivery to the pulmonary circulation. The present devices provide rugged devices which are reusable, use pre-metered unit dose cartridges which deliver a medicament in a liner manner, and can be disassembled for cleaning. The devices also provide a high resistance inhalation system which enables deagglomeration of dry powder particles, have a consistent airflow, are easy to manufacture and are simple and relatively easy to use.
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公开(公告)号：EP2403490B1
公开(公告)日：2019-08-07
申请号：EP10706467.7
申请日：2010-03-04
申请人： MannKind Corporation
发明人： SMUTNEY, Chad, C. , ADAMO, Benoit , POLIDORO, John, M. , KINSEY, P., Spencer , OVERFIELD, Dennis , SAHI, Carl, R. , BILLINGS, Christine , MARINO, Mark, T.
IPC分类号： A61K9/72
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公开(公告)号：EP2254629B1
公开(公告)日：2015-11-04
申请号：EP09724539.3
申请日：2009-03-27
申请人： MannKind Corporation
发明人： SMUTNEY, Chad, C. , KINSEY, P., Spencer , POLIDORO, John, M. , SAHI, Carl, R. , ADAMO, Benoit , MCLEAN, Scott , OVERFIELD, Dennis , BRYANT, Anthony
IPC分类号： A61M15/00
CPC分类号： A61M15/0023 , A61M15/0015 , A61M15/002 , A61M15/0028 , A61M15/0043 , A61M2016/0021 , A61M2016/0027 , A61M2202/064 , A61M2202/07 , A61M2205/58 , A61M2205/581 , A61M2205/582
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10.发明授权INHALER ADAPTOR FOR A LASER DIFFRACTION APPARATUS AND METHOD FOR MEASURING PARTICLE SIZE DISTRIBUTION 有权吸入设备适配器用于测量粒度的激光衍射装置和方法
公开(公告)号：EP2408499B1
公开(公告)日：2014-03-05
申请号：EP10710519.9
申请日：2010-03-18
申请人： MannKind Corporation
发明人： ADAMO, Benoit , SHAH, Saiyam , SMUTNEY, Chad, C.
IPC分类号： A61M15/00
CPC分类号： G01N15/0205 , A61M11/001 , A61M15/00 , A61M15/0065 , A61M2202/064 , A61M2209/02 , G01N15/0211 , G01N15/06 , G01N2015/025
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