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1.发明授权
公开(公告)号：EP2637657B1
公开(公告)日：2019-05-22
申请号：EP11788696.0
申请日：2011-11-09
申请人： MannKind Corporation
发明人： LEONE-BAY, Andrea , STOWELL, Grayson, W. , GUARNERI, Joseph, J. , CARLSON, Dawn, M. , GRANT, Marshall , SMUTNEY, Chad, C.
IPC分类号： A61K31/4045 , A61K31/4196 , A61P25/06
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公开(公告)号：EP2970149A1
公开(公告)日：2016-01-20
申请号：EP14721140.3
申请日：2014-03-14
申请人： MannKind Corporation
IPC分类号： C07D241/08 , A61K38/22 , A61P3/10 , A61K9/00
CPC分类号： C07D241/08 , A61K9/14 , A61K9/5015 , A61K38/26 , A61K38/28 , B01D1/18
摘要： Disclosed herein are DKP microcrystals made by an improved method where they do not irreversibly self-assemble into microparticles. The microcrystals can be dispersed by atomization and re-formed by spray drying into particles having spherical shell morphology. Active agents and excipients can be incorporated into the particles by spray drying a solution containing the components to be incorporated into microcrystalline diketopiperazine particles. In particular, the microcrystalline particle compositions are suitable for pulmonary drug delivery of one or more peptides, proteins, nucleic acids and/or small organic molecules.
摘要翻译： 本文公开了通过改进的方法制备的DKP微晶，其中它们不会不可逆地自组装成微粒。 微晶可通过雾化分散并通过喷雾干燥形成具有球形壳形态的颗粒。 可以通过喷雾干燥含有待掺入微晶二酮哌嗪颗粒的组分的溶液来将活性剂和赋形剂掺入颗粒中。 特别地，微晶颗粒组合物适用于一种或多种肽，蛋白质，核酸和/或小有机分子的肺部药物递送。
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公开(公告)号：EP2776053A1
公开(公告)日：2014-09-17
申请号：EP12784825.7
申请日：2012-10-24
CPC分类号： A61K38/08 , A61K9/0075 , A61K9/14 , A61K31/198 , A61K31/401 , A61K31/405 , A61K31/495 , A61K38/04 , A61K38/07 , A61K47/22 , C07K5/10 , C07K5/1016 , C07K7/06 , A61K2300/00
摘要： Methods and compositions for treating pain are disclosed. The compositions are based on dry powders comprising microparticles of diketopiperazines and an analgesic active agent. The analgesic in the compositions comprises one or more peptide analgesics or derivatives thereof, which are administered to a subject using a pulmonary inhalation drug delivery system comprising a dry powder inhaler and the analgesic composition. The present compositions produce fewer side effects associated with current opioid therapy.
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公开(公告)号：EP2970149B1
公开(公告)日：2019-08-21
申请号：EP14721140.3
申请日：2014-03-14
申请人： MannKind Corporation
IPC分类号： C07D241/08 , A61K38/22 , A61P3/10 , A61K9/50 , B01D1/18
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5.发明公开COMPOSITION COMPRISING A SEROTONIN RECEPTOR AGONIST AND A DIKETOPIPERAZINE FOR TREATING MIGRAINES 审中-公开WITH A SEROTONINREZEPTORAGONIST和偏头痛的治疗哌嗪组成
公开(公告)号：EP2637657A1
公开(公告)日：2013-09-18
申请号：EP11788696.0
申请日：2011-11-09
申请人： MannKind Corporation
发明人： LEONE-BAY, Andrea , STOWELL, Grayson, W. , GUARNERI, Joseph, J. , CARLSON, Dawn, M. , GRANT, Marshall , SMUTNEY, Chad, C.
IPC分类号： A61K31/4045 , A61K31/4196 , A61P25/06
CPC分类号： A61K31/4045 , A61K9/0075 , A61K31/4196
摘要： A method for treating migraines is disclosed. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent, including small molecules and peptides being administered to a patient in need of treatment. In particular, the drug delivery system is designed for inhalation for delivery of drugs to the pulmonary circulation in a rapid and therapeutically effective manner.
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公开(公告)号：EP3021834A1
公开(公告)日：2016-05-25
申请号：EP14750840.2
申请日：2014-07-18
申请人： MannKind Corporation
发明人： FABIO, Karine , GUARNERI, Joseph, J. , CURLEY, Kieran , GRANT, Marshall, L. , LEONE-BAY, Andrea
IPC分类号： A61K9/00 , A61K31/395
CPC分类号： A61K9/1623 , A61K9/0073 , A61K9/1611 , A61K9/1617 , A61K31/198 , A61K31/4172 , A61K38/11 , A61K38/12 , A61K38/23 , A61K38/26 , A61K38/28 , A61K38/29 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are heat-stable dry powders which include peptides or protein such as oxytocin for use as a pharmaceutical composition. The composition is highly stable at increased temperatures and relatively high humid environments, and are intended for storage at room temperature with an improved shelf-life. In particular, the dry powders are intended for inhalation, however, other routes of administration can be used when reconstituted in solution.
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