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公开(公告)号：EP0831926A1
公开(公告)日：1998-04-01
申请号：EP96916251.0
申请日：1996-06-07
发明人： DUGSTAD, Harald , KLAVENESS, Jo , RONGVED, Pal , SKURTVEIT, Roald
IPC分类号： A61K49
CPC分类号： A61K49/227
摘要： Diagnostic contrast agents having microbubbles of gas or a gas precursor stabilised by one or more membrane-forming lipids crosslinked or polymerised in the hydrophilic portion thereof may exhibit high degrees of stability and contrast efficacy.
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2.发明公开
公开(公告)号：EP1069888A1
公开(公告)日：2001-01-24
申请号：EP99915906.4
申请日：1999-04-09
申请人： NYCOMED IMAGING AS
发明人： FOSSHEIM, Sigrid, Lise , KLAVENESS, Jo , BJ RNERUD, Atle , RONGVED, Pal , GOLMAN, Klaes , SKURTVEIT, Roald
CPC分类号： A61B5/01 , A61B5/055 , A61B5/416 , A61B5/4519 , A61B8/481 , A61K49/1812 , A61K49/223
摘要： The present invention relates to a method of imaging of an animate human or non-human animal body, which method comprises: administering parenterally to said body a particulate material comprising a matrix or membrane material and at least one contrast generating species, which matrix or membrane material is responsive to a pre-selected physiological parameter whereby to alter the contrast efficacy of said species in response to a change in the value of said parameters; generating image data of at least part of said body in which said species is present; and generating therefrom a signal indicative of the value or variation of said parameter in said part of said body. The invention also relates to contrast media for imaging a physiological parameter.
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公开(公告)号：EP0744960A1
公开(公告)日：1996-12-04
申请号：EP95908328.0
申请日：1995-02-15
发明人： DUGSTAD, Harald , FOSS, Per, Antonius , KLAVENESS, Jo , RONGVED, Pal , SKURTVEIT, Roald , SOLBERG, Jan , AUKRUST, Inger, Reidun, Fjeldskaar
IPC分类号： A61K49
CPC分类号： A61K49/223
摘要： Microparticulate contrast agents comprising gas or a gas precursor encapsulated by a non-polymeric and non-polymerisable wall-forming material are readily characterisable materials exhibiting surprising structural integrity and stability.
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4.发明公开POLYMERIC SURFACTANT-ENCAPSULATED MICROBUBBLES AND THEIR USE IN ULTRASOUND IMAGING 失效微小气泡，与聚合物的KAPSELD表面活性剂和它们在超声诊断学商定
公开(公告)号：EP0717658A1
公开(公告)日：1996-06-26
申请号：EP94925549.0
申请日：1994-09-05
申请人： NYCOMED IMAGING AS
发明人： DUGSTAD, Harald , FOSS, Per, Antonius , KLAVENESS, Jo , REDFORD, Keith , RONGVED, Pal , SKURTVEIT, Roald
CPC分类号： B01F17/0028 , A61K49/223 , Y10T428/2985
摘要： Polymer-based gas-containing contrast agents in which microbubbles of gas are encapsulated by non-polymerisable wall-forming block or graft copolymer surfactants. The polymer surfactants are preferably biodegradable and include block and graft copolymers containing linkages of formula (I): -(O)m-CO-O-C(R1R2)-O-CO-(O)¿n?- (where R?1 and R2¿ each represent a hydrogen atom or a carbon-attached monovalent organic group or R?1 and R2¿ together form a carbon-attached divalent organic group and m and n are each zero or 1) which are themselves novel.
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5.发明授权POLYMERIC SURFACTANT-ENCAPSULATED MICROBUBBLES AND THEIR USE IN ULTRASOUND IMAGING 失效微小气泡，与聚合物的KAPSELD表面活性剂和它们在超声诊断学商定
公开(公告)号：EP0717658B1
公开(公告)日：2002-04-17
申请号：EP94925549.1
申请日：1994-09-05
申请人： Nycomed Imaging AS
发明人： DUGSTAD, Harald , FOSS, Per, Antonius , KLAVENESS, Jo , REDFORD, Keith , RONGVED, Pal , SKURTVEIT, Roald
CPC分类号： B01F17/0028 , A61K49/223 , Y10T428/2985
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