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公开(公告)号：EP0744960A1
公开(公告)日：1996-12-04
申请号：EP95908328.0
申请日：1995-02-15
发明人： DUGSTAD, Harald , FOSS, Per, Antonius , KLAVENESS, Jo , RONGVED, Pal , SKURTVEIT, Roald , SOLBERG, Jan , AUKRUST, Inger, Reidun, Fjeldskaar
IPC分类号： A61K49
CPC分类号： A61K49/223
摘要： Microparticulate contrast agents comprising gas or a gas precursor encapsulated by a non-polymeric and non-polymerisable wall-forming material are readily characterisable materials exhibiting surprising structural integrity and stability.
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公开(公告)号：EP0689462A1
公开(公告)日：1996-01-03
申请号：EP94909227.0
申请日：1994-03-16
发明人： AABYE, Arne , BERG, Arne , DUGSTAD, Harald , DYVIK, Kari , FOSS, Per, Antonius , KLAVENESS, Jo , OSTENSEN, Jonny , RONGVED, P l , STRANDE, Per , TOLLESHAUG, Helge
IPC分类号： A61K49
CPC分类号： A61K49/227 , A61K49/223
摘要： Microparticulate materials which are capable of chemical generation of gas after formulation with an appropriate carrier liquid, e.g. water for injection, and/or after administration to a subject, e.g. as a result of exposure to blood or other body fluids, may be used as contrast agents in diagnostic imaging, particularly ultrasound and magnetic resonance imaging.
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公开(公告)号：EP0689461A1
公开(公告)日：1996-01-03
申请号：EP94909226.0
申请日：1994-03-16
发明人： BERG, Arne , DUGSTAD, Harald , FOSS, Per, Antonius , KLAVENESS, Jo , OSTENSEN, Jonny , RONGVED, Pal , STRANDE, Per
CPC分类号： A61K49/226 , A61K49/223
摘要： Oil-in-water emulsions in which the oil phase comprises condensed or dissolved oil-soluble gas/fluid or gas precursor are useful as ultrasound contrast agents. Such products contain insignificant amounts of free gas bubbles or microbubbles in their stored form and exhibit good storage stability, but may be designed to promote rapid microbubble generation immediately before or upon administration.
摘要翻译： 其中油相包含冷凝或溶解的油溶性气体/流体或气体前体的水包油乳液可用作超声造影剂。 这些产品在其储存的形式中含有微不足道的游离气泡或微泡，并且表现出良好的储存稳定性，但可以设计为在施用之前或之后立即促进快速微泡产生。
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公开(公告)号：EP0689461B1
公开(公告)日：2000-07-05
申请号：EP94909226.6
申请日：1994-03-16
申请人： NYCOMED IMAGING AS
发明人： BERG, Arne , DUGSTAD, Harald , FOSS, Per, Antonius , KLAVENESS, Jo , OSTENSEN, Jonny , RONGVED, Pal , STRANDE, Per
IPC分类号： A61K49/00
CPC分类号： A61K49/226 , A61K49/223
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5.发明公开POLYMERIC SURFACTANT-ENCAPSULATED MICROBUBBLES AND THEIR USE IN ULTRASOUND IMAGING 失效微小气泡，与聚合物的KAPSELD表面活性剂和它们在超声诊断学商定
公开(公告)号：EP0717658A1
公开(公告)日：1996-06-26
申请号：EP94925549.0
申请日：1994-09-05
申请人： NYCOMED IMAGING AS
发明人： DUGSTAD, Harald , FOSS, Per, Antonius , KLAVENESS, Jo , REDFORD, Keith , RONGVED, Pal , SKURTVEIT, Roald
CPC分类号： B01F17/0028 , A61K49/223 , Y10T428/2985
摘要： Polymer-based gas-containing contrast agents in which microbubbles of gas are encapsulated by non-polymerisable wall-forming block or graft copolymer surfactants. The polymer surfactants are preferably biodegradable and include block and graft copolymers containing linkages of formula (I): -(O)m-CO-O-C(R1R2)-O-CO-(O)¿n?- (where R?1 and R2¿ each represent a hydrogen atom or a carbon-attached monovalent organic group or R?1 and R2¿ together form a carbon-attached divalent organic group and m and n are each zero or 1) which are themselves novel.
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6.发明授权POLYMERIC SURFACTANT-ENCAPSULATED MICROBUBBLES AND THEIR USE IN ULTRASOUND IMAGING 失效微小气泡，与聚合物的KAPSELD表面活性剂和它们在超声诊断学商定
公开(公告)号：EP0717658B1
公开(公告)日：2002-04-17
申请号：EP94925549.1
申请日：1994-09-05
申请人： Nycomed Imaging AS
发明人： DUGSTAD, Harald , FOSS, Per, Antonius , KLAVENESS, Jo , REDFORD, Keith , RONGVED, Pal , SKURTVEIT, Roald
CPC分类号： B01F17/0028 , A61K49/223 , Y10T428/2985
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